Chimeric antigens for eliciting an immune response
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United States of America Patent
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Sep 27, 2011
Grant Date -
Jan 20, 2005
app pub date -
Aug 5, 2004
filing date -
Jun 20, 2002
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Abstract
Disclosed herein are compositions and methods for eliciting immune responses against antigens. In particular embodiments, the compounds and methods elicit immune responses against antigens that are otherwise recognized by the host as “self” antigens. The immune response is enhanced by presenting the host immune system with a chimeric antigen comprising an immune response domain and a target binding domain, wherein the target binding domain comprises a xenotypic antibody fragment. By virtue of the target binding domain, antigen presenting cells take up, process, and present the chimeric antigen, eliciting both a humoral and cellular immune response.
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