Protofibril selective antibodies and the use thereof
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United States of America Patent
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Sep 27, 2011
Grant Date -
Oct 15, 2009
app pub date -
Mar 23, 2007
filing date -
Mar 23, 2006
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Abstract
The present invention pertains to the prevention, treatment and diagnosis of neurodegenerative diseases, in particular Alzheimer's disease, and other similar disease. More specifically to high affinity antibodies selective for amyloid beta protein (Aβ) in its protofibril conformation and of IgG class and IgG1 or IgG4 subclass or combinations thereof or mutations thereof, retaining high Fc receptor binding and low C1(C1q) binding, effective in clearance of Aβ protofibrils and with reduce risk of inflammation.
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