Bifunctional analgesic compounds for opioid receptor agonists and neurokinin-1 receptor antagonists
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United States of America Patent
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Sep 27, 2011
Grant Date -
Feb 14, 2008
app pub date -
Jun 8, 2007
filing date -
Apr 26, 2006
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Abstract
The present invention provides a novel chimeric compound comprising an agonist opioid receptor binding moiety at its N-terminus and an antagonist neurokinin-1 (NK1) receptor binding moiety at its C-terminus for producing analgesia, a pharmaceutical composition comprising the chimeric compound, a method of making the compound, and a method of treating pain using the novel chimeric compounds.
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