Parenteral CCI-779 formulations containing cosolvents, an antioxidant, and a surfactant
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United States of America Patent
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Sep 27, 2011
Grant Date -
Aug 26, 2004
app pub date -
Jul 25, 2003
filing date -
Jul 30, 2002
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Abstract
Parenteral formulations of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl) -2-methylpropionic acid (CCI-779) are provided. One parenteral formulation contains CCI-779, an alcoholic co-solvent, and an antioxidant. Another parenteral formulation contains CCI-779, an alcoholic solvent, an antioxidant, a diluent solvent, and a surfactant. Processes for preparing parenteral CCI-779 formulations using a co-solvent concentrate are also provided.
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