Fluorescent membrane intercalating probes and methods for their use
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United States of America Patent
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Oct 4, 2011
Grant Date -
Jan 7, 2010
app pub date -
Dec 8, 2008
filing date -
Mar 3, 2000
priority date (Note) -
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Abstract
The invention relates to a family of cyanine dyes which fluoresce in the far red and near infra red wavelengths of the spectrum and preferably possess lipophilic side chains. The dyes of the invention are soluble in commercially available membrane staining vehicles, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well retained therein. Methods of using the dyes to detect stained cells both in vivo and in vitro are also disclosed.
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