Method using snail transcriptional repressor
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United States of America Patent
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Oct 4, 2011
Grant Date -
Sep 17, 2009
app pub date -
Aug 25, 2006
filing date -
Aug 26, 2005
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Abstract
Provided is a prognostic molecular marker for breast cancer recurrence. Expression of Snail, a zinc finger transcriptional repressor gene, is correlated to the risk of breast cancer recurrence, and to the likelihood of recurrence-free survival in subjects diagnosed with breast cancer. Further provided are methods of identifying therapeutic compositions for treating breast cancer to reduce recurrence associated with high expression of Snail, and methods of controlling Snail expression for research and therapeutic purposes.
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