US Patent No: 8,034,554

Number of patents in Portfolio can not be more than 2000

Methods and compositions to detect nucleic acids in a biological sample

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ALSO PUBLISHED AS: 20060068417
ATTORNEY / AGENT: (SPONSORED)
 

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Abstract

Methods of the invention separate a target nucleic acid from a sample by using at least one capture probe oligonucleotide that contains a target-complementary region and a member of a specific binding pair that attaches the target nucleic acid to an immobilized probe on a capture support, thus forming a capture hybrid that is separated from other sample components before the target nucleic acid is released from the capture support and hybridized to a detection probe to form a detection hybrid that produces a detectable signal that indicates the presence of the target nucleic acid in the sample. Compositions for practicing the methods of the invention include a capture probe oligonucleotide made up a target-complementary region sequence and a covalently linked capture region sequence that includes a member of a specific binding pair.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
GEN-PROBE INCORPORATEDSAN DIEGO, CA383

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Becker, Michael M San Diego, CA 68 337
Majlessi, Mehrdad R Escondido, CA 14 36

Cited Art

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UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (1)
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UNIVERSITY OF ROCHESTER (1)
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