Methods and compositions for inhibition of angiogenesis
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United States of America Patent
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Oct 18, 2011
Grant Date -
Feb 5, 2009
app pub date -
Oct 10, 2008
filing date -
Nov 5, 1996
priority date (Note) -
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Abstract
The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis and to treat disease states resulting from angiogenesis. Additionally, antiinflammatory drugs, such as steroids and NSAIDs can inhibit angiogenesis dependent diseases either alone or in combination with thalidomide and related compounds. Importantly, these compounds can be administered orally.
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