Stable composition of GDF-5 and method of storage
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United States of America Patent
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Nov 15, 2011
Grant Date -
Feb 12, 2009
app pub date -
Jul 16, 2008
filing date -
Aug 7, 2007
priority date (Note) -
Expired
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Abstract
Improved compositions and methods are provided for stabilizing a solution of bone morphogenetic protein. The compositions comprise an aqueous solution of GDF-5 and a biocompatible acid, such as hydrochloric, acetic, phosphoric, or trifluoroacetic acid, wherein the solution has a pH of from about 3.0 to about 3.6, thereby providing for improved stability of the GDF-5 protein during handling and prolonged storage at reduced temperatures.
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