Inhibitors of ion channels
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United States of America Patent
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Nov 22, 2011
Grant Date -
Feb 18, 2010
app pub date -
Sep 16, 2009
filing date -
Aug 16, 2005
priority date (Note) -
Expired
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Abstract
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides heterocyclic aryl sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.
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