US Patent No: 8,066,763

Drug-releasing stent with ceramic-containing layer

Stats

Nov 29, 2011
Issued date
May 11, 2010
filing date
12/777,705
serial no
In Force
status

ALSO PUBLISHED AS: 20100286763

Importance

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Abstract

A vascular or endoluminal stent is adapted to be implanted in a vessel, duct or tract of a human body to maintain an open lumen. The stent includes a base layer of a biologically compatible metal. An intermediate metal particle layer of substantial greater radiopacity overlies the base layer, with particles bonded to the base layer and to each other to leave interstices therebetween as a repository for retaining and dispensing drugs or other agents for time release therefrom. The particles are composed primarily of a noble metal. Exposed surfaces of the particle layer are coated with ceramic-like iridium oxide or titanium nitrate, as a biocompatible material to inhibit irritation of tissue at the inner lining of the vessel when the stent is implanted.

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First Claim

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Related Publications

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Patent Owner(s)

Patent Owner	Address	Total Patents
BOSTON SCIENTIFIC SCIMED, INC.	MAPLE GROVE, MN	4439

International Classification(s)

A61F:FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES....

[Classification Symbol]

[Patents Count]

Inventor(s)

Inventor Name	Address	# of filed Patents	Total Citations
Alt, Eckhard	Ottobrunn, DE	120	5063

Cited Art

Patent Info	# Cites	Year
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2005/0163,954 Medical devices	41	2004
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2008/0004,691 MEDICAL DEVICES WITH SELECTIVE COATING	34	2007
2009/0018,639 ENDOPROSTHESIS COATING	33	2007
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2008/0071,355 Medical Devices with Drug-Eluting Coating	40	2007
2008/0071,348 Medical Devices	33	2007
2008/0071,349 Medical Devices	38	2007
2008/0071,350 ENDOPROSTHESES	35	2007
2008/0071,358 ENDOPROSTHESES	36	2007
2009/0076,588 Endoprosthesis	35	2007
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2008/0071,353 ENDOPROSTHESIS CONTAINING MAGNETIC INDUCTION PARTICLES	35	2007
2008/0086,201 MAGNETIZED BIOERODIBLE ENDOPROSTHESIS	35	2007
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2008/0145,400 Ion Bombardment of Medical Devices	34	2007
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2009/0118,814 ENDOPROSTHESIS COATING	33	2007
2009/0118,815 STENT	34	2007
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2009/0118,822 STENT WITH EMBEDDED MATERIAL	34	2007
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7,749,264 Medical devices and methods of making the same	34	2008
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2009/0281,613 Endoprostheses	34	2008
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2009/0306,765 Bioerodible Endoprosthesis	34	2008
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2009/0149,942 ENDOPROSTHESIS HAVING A NON-FOULING SURFACE	33	2008
2009/0028,785 MEDICAL DEVICES WITH COATINGS FOR DELIVERY OF A THERAPEUTIC AGENT	34	2008
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2010/0030,326 Bioerodible Endoprosthesis	33	2008
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2010/0008,970 Drug-Eluting Endoprosthesis	34	2008
2009/0202,610 Medical Implants With Polysaccharide Drug Eluting Coatings	34	2009
2009/0259,300 Medical Devices With an Interlocking Coating and Methods of Making the Same	33	2009
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2009/0319,032 ENDOPROSTHESIS COATING	10	2009
2010/0028,403 MEDICAL DEVICES FOR THERAPEUTIC AGENT DELIVERY	10	2009
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2010/0070,022 LAYER BY LAYER MANUFACTURING OF A STENT	21	2009
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6,805,898 Surface features of an implantable medical device	136	2000
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6,656,506 Microparticle coated medical device	148	2001
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6,712,844 MRI compatible stent	58	2001
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6,753,071 Rate-reducing membrane for release of an agent	203	2001
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6,866,805 Hybrid intravascular stent	65	2001
6,616,765 Apparatus and method for depositing a coating onto a surface of a prosthesis	180	2002
6,723,120 Medicated porous metal prosthesis	170	2002
2004/0088,038 Porous metal for drug-loaded stents	64	2002
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6,908,624 Coating for implantable devices and a method of forming the same	84	2002
6,725,901 Methods of manufacture of fully consolidated or porous medical devices	52	2002
6,896,697 Intravascular stent	56	2002
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7,163,715 Spray processing of porous medical devices	52	2002
2004/0224,001 Stent coatings comprising hydrophilic additives	75	2003
2004/0230,293 INTRAVASCULAR STENT	61	2003
6,846,323 Intravascular stent	133	2003
2005/0021,127 Porous glass fused onto stent for drug retention	43	2003
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7,247,166 Intravascular stent with extendible end rings	20	2003
2005/0069,630 Stent mandrel fixture and method for selectively coating surfaces of a stent	53	2003
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7,563,324 System and method for coating an implantable medical device	19	2003
2004/0234,737 Rate-reducing membrane for release of an agent	40	2004
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7,416,558 Drug-eluting stent cover and method of use	34	2006
2007/0032,858 Stent with drug coating	35	2006
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2007/0055,349 Stent with drug coating	35	2006
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2005/0137,677 Endovascular graft with differentiable porosity along its length	55	2003
2004/0236,416 Increased biocompatibility of implantable medical devices	43	2004
2006/0200,229 Geometry and material for use in high strength, high flexibility, controlled recoil drug eluting stents	36	2005
2008/0086,199 BIOABSORBABLE DEVICE HAVING COMPOSITE STRUCTURE FOR ACCELERATING DEGRADATION	43	2006
2008/0152,929 POLYMER COATING FOR MEDICAL DEVICES	33	2006
2010/0131,050 ABSORBABLE STENT HAVING A COATING FOR CONTROLLING DEGRADATION OF THE STENT AND MAINTAINING pH NEUTRALITY	32	2008
SCIMED LIFE SYSTEMS, INC. (15)
5,464,450 Biodegradable drug delivery vascular stent	245	1994
5,551,954 Biodegradable drug delivery vascular stent	253	1994
5,500,013 Biodegradable drug delivery vascular stent	280	1995
5,769,883 Biodegradable drug delivery vascular stent	265	1995
6,387,124 Biodegradable drug delivery vascular stent	93	1999
6,395,325 Porous membranes	52	2000
2002/0138,136 Medical device having radio-opacification and barrier layers	53	2001
2002/0065,553 Method for manufacturing a medical device having a coated portion by laser ablation	107	2001
6,652,575 Stent with smooth ends	91	2001
6,869,443 Biodegradable drug delivery vascular stent	98	2002
2004/0086,674 Laser sintering process and devices made therefrom	30	2002
2004/0098,119 Stent with smooth ends	37	2003
2006/0127,442 Use of supercritical fluids to incorporate biologically active agents into nanoporous medical articles	22	2004
2005/0278,016 Stent designed for the delivery of therapeutic substance or other agents	42	2005
2006/0264,138 Composite ePTFE/textile prosthesis	37	2006
MEDTRONIC VASCULAR, INC. (14)
6,918,929 Drug-polymer coated stent with pegylated styrenic block copolymers	29	2003
7,001,421 Stent with phenoxy primer coating	37	2003
6,979,348 Reflowed drug-polymer coated stent and method thereof	53	2003
2005/0070,996 Drug-eluting stent for controlled drug delivery	49	2003
2006/0149,365 Stent with eccentric coating	21	2003
2004/0111,150 Medical device for delivering a therapeutic substance and method therefor	33	2003
2004/0236,415 Medical devices having drug releasing polymer reservoirs	41	2003
2005/0180,919 Stent with radiopaque and encapsulant coatings	39	2004
2004/0230,176 System for treating a vascular condition that inhibits restenosis at stent ends	52	2004
2004/0236,399 Stent with improved surface adhesion	27	2004
2005/0021,128 Compliant, porous, rolled stent	36	2004
2005/0267,561 System and method for stent deployment and infusion of a therapeutic agent into tissue adjacent to the stent ends	33	2004
7,575,593 Implantable device with reservoirs for increased drug loading	22	2007
2008/0243,240 Biodegradable Metal Barrier Layer for a Drug-Eluting Stent	34	2007
UNIVERSITY OF VIRGINIA (14)
7,294,409 Medical devices having porous layers and methods for making same	36	2003
2005/0070,989 Medical devices having porous layers and methods for making the same	42	2004
2006/0121,080 Medical devices having nanoporous layers and methods for making the same	57	2005
2006/0193,886 Medical devices with nanoporous layers and topcoats	40	2006
2006/0193,887 Medical devices having nanoporous bonding layers	39	2006
2006/0193,888 Methods for using medical devices having nanoporous layers	38	2006
2006/0193,889 Nanoporous layers using thermal dealloying	38	2006
2006/0193,890 Method for loading nanoporous layers with therapeutic agent	41	2006
2006/0276,877 Dealloyed nanoporous stents	39	2006
2006/0276,878 Dealloyed nanoporous stents	39	2006
2006/0276,884 Nanoporous stents with magnesium leaching	40	2006
2006/0276,885 Nanoporous stents with improved radiolucency	40	2006
2006/0271,169 Stent with nanoporous surface	34	2006
2006/0276,879 Medical devices having porous layers and methods for making the same	36	2006
MEDTRONIC, INC. (13)
4,886,062 Intravascular radially expandable stent and method of implant	1153	1987
5,607,463 Intravascular medical device	254	1993
5,443,496 Intravascular radially expandable stent	363	1993
5,545,208 Intralumenal drug eluting prosthesis	260	1993
5,591,224 Bioelastomeric stent	227	1994
5,624,411 Intravascular stent and method	457	1995
5,776,184 Intravasoular stent and method	322	1996
5,824,048 Method for delivering a therapeutic substance to a body lumen	363	1996
6,203,536 Medical device for delivering a therapeutic substance and method therefor	57	1997
6,730,120 Medical device for delivering a therapeutic substance and method therefor	49	2001
2005/0055,080 Modulated stents and methods of making the stents	46	2003
2004/0220,510 Occlusion resistant hydrocephalic shunt	44	2004
2005/0079,199 Porous coatings for drug release from medical devices	42	2004
MEDLOGICS DEVICE CORPORATION (12)
2003/0060,873 Metallic structures incorporating bioactive materials and methods for creating the same	60	2002
7,208,172 Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices	34	2003
2005/0119,723 Medical device with porous surface containing bioerodable bioactive composites and related methods	47	2003
2005/0106,212 Metallic structures incorporating bioactive materials and methods for creating the same	40	2004
2005/0186,250 Metallic structures incorporating bioactive materials and methods for creating the same	33	2005
2006/0062,820 Metallic structures incorporating bioactive materials and methods for creating the same	39	2005
2006/0051,397 Metallic structures incorporating bioactive materials and methods for creating the same	34	2005
2006/0085,062 Implantable stent with endothelialization factor	33	2005
2006/0115,512 Metallic structures incorporating bioactive materials and methods for creating the same	36	2005
2007/0073,390 Methods and devices for enhanced adhesion between metallic substrates and bioactive material-containing coatings	33	2005
2007/0071,789 Bioactive Material Delivery Systems Comprising Sol-Gel Compositions	19	2006
2007/0181,433 METALLIC COMPOSITE COATINGS FOR DELIVERY OF THERAPEUTIC AGENTS FROM THE SURFACE OF IMPLANTABLE DEVICES	33	2007
INNOVATIONAL HOLDINGS LLC (10)
6,241,762 Expandable medical device with ductile hinges	197	1998
2003/0009,214 Medical device with beneficial agent delivery mechanism	60	2002
7,056,338 Therapeutic agent delivery device with controlled therapeutic agent release rates	63	2003
2004/0142,014 Method and apparatus for reducing tissue damage after ischemic injury	53	2003
2004/0143,321 Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor	57	2003
2004/0202,692 Implantable medical device and method for in situ selective modulation of agent delivery	55	2004
2005/0100,577 Expandable medical device with beneficial agent matrix formed by a multi solvent system	42	2004
2004/0254,635 Expandable medical device for delivery of beneficial agent	45	2004
2006/0222,679 System and method for loading a beneficial agent into a medical device	35	2006
2006/0229,713 Implantable medical device with openings for delivery of beneficial agents with combination release kinetics	36	2006
WYETH (10)
7,261,735 Local drug delivery devices and methods for maintaining the drug coatings thereon	45	2001
7,195,640 Coated medical devices for the treatment of vulnerable plaque	53	2002
2004/0002,755 Method and apparatus for treating vulnerable coronary plaques using drug-eluting stents	22	2002
2003/0204,168 Coated vascular devices	118	2002
2004/0167,572 Coated medical devices	178	2003
2005/0136,090 Local vascular delivery of trichostatin a alone or in combination with sirolimus to prevent restenosis following vascular injury	57	2003
2005/0004,663 Heparin barrier coating for controlled drug release	64	2004
2005/0033,417 Coating for controlled release of a therapeutic agent	52	2004
2006/0129,225 Device for the delivery of a cardioprotective agent to ischemic reperfused myocardium	51	2004
2007/0135,908 Absorbable stent comprising coating for controlling degradation and maintaining pH neutrality	38	2005
MED INSTITUTE, INC. (9)
5,609,629 Coated implantable medical device	576	1995
6,096,070 Coated implantable medical device	672	1996
5,824,049 Coated implantable medical device	658	1996
5,873,904 Silver implantable medical device	657	1997
6,530,951 Silver implantable medical device	254	1997
6,299,604 Coated implantable medical device	497	1999
6,918,927 Coated implantable medical device	108	2001
2005/0278,021 Coated medical device	57	2005
2007/0073,385 Eluting, implantable medical device	52	2006
BIOPHAN TECHNOLOGIES, INC. (8)
6,506,972 Magnetically shielded conductor	76	2002
6,673,999 Magnetically shielded assembly	71	2002
6,713,671 Magnetically shielded assembly	68	2002
6,765,144 Magnetic resonance imaging coated assembly	86	2003
6,815,609 Nanomagnetic composition	53	2003
2005/0107,870 Medical device with multiple coating layers	107	2004
2006/0142,853 Coated substrate assembly	23	2005
2006/0140,867 Coated stent assembly and coating materials	16	2005
CID S.P.A. (8)
6,638,302 Stent for angioplasty and associated production process	85	1997
6,565,602 Angioplasty stents	63	2001
6,699,281 Angioplasty stents	85	2002
2003/0195,613 Stent for angioplasty and associated production process	45	2003
7,344,563 Angioplasty stents	37	2004
2005/0209,681 Stent for endoluminal delivery of active principles or agents	39	2005
2007/0151,093 STENT FOR ANGIOPLASTY AND ASSOCIATED PRODUCTION PROCESS	34	2007
2008/0140,186 PROCESS FOR PRODUCING STENTS AND CORRESPONDING STENTS	39	2008
AVANTEC VASCULAR CORPORATION (6)
6,471,980 Intravascular delivery of mycophenolic acid	114	2001
7,077,859 Apparatus and methods for variably controlled substance delivery from implanted prostheses	70	2001
2003/0033,007 Methods and devices for delivery of therapeutic capable agents with variable release profile	56	2002
7,083,642 Delivery of therapeutic capable agents	43	2002
2005/0107,869 Apparatus and methods for controlled substance delivery from implanted prostheses	27	2004
2006/0212,109 Delivery of therapeutic capable agents	22	2006
BOSTON SCIENTIFIC CORPORATION (6)
5,954,706 Drug delivery	109	1995
5,843,089 Stent lining	113	1996
5,928,247 Stent placement device with medication dispenser and method	41	1997
6,364,856 Medical device with sponge coating for controlled drug release	109	1998
5,968,092 Method for making a biodegradable stent	129	1998
6,514,283 Intraluminal lining	97	2001
CORVITA CORPORATION (5)
4,657,544 Cardiovascular graft and method of forming same	85	1984
4,738,740 Method of forming implantable vascular grafts	118	1985
4,743,252 Composite grafts	217	1986
5,741,331 Biostable elastomeric polymers having quaternary carbons	112	1996
5,968,091 Stents and stent grafts having enhanced hoop strength and methods of making the same	199	1997
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (5)
5,888,591 Chemical vapor deposition of fluorocarbon polymer thin films	67	1996
5,797,898 Microchip drug delivery devices	285	1996
6,013,591 Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production	129	1998
6,045,877 Pyrolytic chemical vapor deposition of silicone films	98	1998
6,156,435 Chemical vapor deposition of fluorocarbon polymer thin films	33	1999
SORIN BIOMEDICA CARDIO S.R.L. (5)
2004/0167,612 Process for producing stents and corresponding stents	37	2004
2007/0065,418 Method and device for cellular therapy	35	2006
2007/0219,626 Stents made of biodegradable and non-biodegradable materials	35	2007
2007/0191,928 Angioplasty stents	34	2007
2008/0288,048 STENTS FOR ANGIOPLASTY	33	2007
ABPS VENTURE ONE, LTD. (4)
6,458,153 Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof	259	1999
6,652,578 Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof	161	2001
2003/0023,300 Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof	108	2002
2006/0167,543 Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof	87	2006
BIOTRONIK MESS-UND THERAPIEGERAETE GMBH & CO. (4)
6,805,709 Stent having discontinuous coating in the form of coating islands	62	2000
6,899,914 Method of applying a marker element to an implant and an implant provided with a marker element	33	2001
6,849,089 Implant with proliferation-inhibiting substance	59	2002
2005/0027,350 Endovascular implant for the injection of an active substance into the media of a blood vessel	36	2003
ISOTECHNIKA INC. (4)
6,342,507 Deuterated rapamycin compounds, method and uses thereof	37	1999
6,503,921 Deuterated rapamycin compounds, methods and uses thereof	40	2001
6,710,053 Deuterated rapamycin compounds, method and uses thereof	34	2002
6,884,429 Medical devices incorporating deuterated rapamycin for controlled delivery thereof	48	2002
REGENTS OF THE UNIVERSITY OF MINNESOTA (4)
4,585,652 Electrochemical controlled release drug delivery system	171	1984
5,874,134 Production of nanostructured materials by hypersonic plasma particle deposition	65	1997
6,924,004 Apparatus and method for synthesizing films and coatings by focused particle beam deposition	30	2001
7,247,338 Coating medical devices	31	2002
SURMODICS, INC. (4)
2005/0019,371 Controlled release bioactive agent delivery device	51	2004
2005/0244,459 Coating compositions for bioactive agents	46	2005
2005/0196,424 Medical devices and methods for producing the same	41	2005
7,547,445 Crosslinkable macromers	33	2006
ABBOTT CARDIOVASCULAR SYSTEMS INC. (3)
2003/0083,731 Manufacture of fine-grained material for use in medical devices	41	2001
7,691,461 Hybrid stent and method of making	21	2002
2008/0306,584 Implantable medical devices for local and regional treatment	34	2007
ABBOTT LABORATORIES (3)
7,837,726 Visible endoprosthesis	18	2006
2007/0191,943 Integration Of Therapeutic Agent Into A Bioerodible Medical Device	39	2006
2008/0057,103 METHODS OF USING MEDICAL DEVICES FOR CONTROLLED DRUG RELEASE	18	2007
ANGIOTECH INTERNATIONAL AG (3)
6,689,803 Compositions and methods for treating surgical adhesions	55	2002
2004/0219,214 Tissue reactive compounds and compositions and uses thereof	53	2003
2005/0165,467 Intravascular devices and fibrosis-inducing agents	19	2004
ANGIOTECH PHARMACEUTICALS, INC. (3)
6,106,473 Echogenic coatings	139	1997
2002/0165,265 ANTI-ANGIOGENIC COMPOSITIONS AND METHODS OF USE	54	1997
6,846,841 Anti-angiogenic compositions and methods of use	49	2002
BIOSENSORS INTERNATIONAL GROUP, LTD. (3)
2003/0225,450 Drug-delivery endovascular stent and method for treating restenosis	31	2003
2006/0069,427 Drug-delivery endovascular stent and method for treating restenosis	39	2005
2007/0173,923 Drug reservoir stent	52	2006
CARDIAC PACEMAKERS, INC. (3)
6,212,434 Single pass lead system	81	1998
2005/0131,509 Coatings for implantable electrodes	46	2003
2006/0035,026 Coatings for implantable electrodes	37	2005
DEPUY PRODUCTS, INC. (3)
6,569,489 Bioactive ceramic coating and method	80	2000
6,736,849 Surface-mineralized spinal implants	37	2002
7,368,065 Implants with textured surface and methods for producing the same	22	2005
ICON INTERVENTIONAL SYSTEMS, INC. (3)
6,206,916 Coated intraluminal graft	122	1999
2002/0099,438 Irradiated stent coating	64	2001
2007/0032,864 Thrombosis inhibiting graft	34	2005
MEDINOL LTD. (3)
5,449,373 Articulated stent	625	1994
6,315,794 Multilayered metal stent	131	1999
2006/0178,727 Hybrid amorphous metal alloy stent	34	2006
PRESIDENT AND FELLOWS OF HARVARD COLLEGE (3)
5,951,881 Fabrication of small-scale cylindrical articles	118	1996
6,776,094 Kit For Microcontact Printing	156	1998
2004/0178,523 Molded waveguides	24	2003
UNIVERSITY OF CONNECTICUT (3)
2005/0010,275 Implantable medical devices	69	2003
2005/0216,074 Implantable medical devices	77	2004
2005/0251,249 Endoprostheses	45	2005
ABBOTT LABORATORIES VASCULAR ENTERPRISES LIMITED (2)
2004/0133,270 Drug eluting stent and methods of manufacture	45	2003
2006/0155,361 Stent with rough surface and its manufacture	36	2003
ALCOVE SURFACES GMBH (2)
6,709,379 Implant with cavities containing therapeutic agents	173	2001
6,740,077 Implant with permeable element	41	2001
AMS MEDINVENT S.A. (2)
4,655,771 Prosthesis comprising an expansible or contractile tubular body	1200	1983
5,061,275 Self-expanding prosthesis	585	1989
ATRIUM MEDICAL CORPORATION (2)
6,955,661 Expandable fluoropolymer device for delivery of therapeutic agents and method of making	49	1999
2003/0153,901 Drug delivery panel	46	2002
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (2)
2003/0050,687 Biocompatible stents and method of deployment	57	2001
7,238,199 Method and apparatus for stent deployment with enhanced delivery of bioactive agents	37	2002
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (2)
2003/0083,614 Controlled release endoprosthetic device	37	2002
2005/0192,664 Controlled release endoprosthetic device	33	2005
CAP BIOTECHNOLOGY, INC. (2)
6,210,715 Calcium phosphate microcarriers and microspheres	103	2000
6,358,532 Calcium phosphate microcarriers and microspheres	31	2001
COOK INCORPORATED (2)
4,800,882 Endovascular stent and delivery system	1134	1987
2005/0159,804 Multiple stitches for attaching stent to graft	47	2005
DIMICRON, INC. (2)
6,488,715 Diamond-surfaced cup for use in a prosthetic joint	53	2000
6,514,289 Diamond articulation surface for use in a prosthetic joint	29	2000
ELECTROFORMED STENTS, INC. (2)
2004/0237,282 Process for forming a porous drug delivery layer	37	2003
6,904,658 Process for forming a porous drug delivery layer	50	2003
EXXON RESEARCH AND ENGINEERING COMPANY (2)
4,407,695 Natural lithographic fabrication of microstructures over large areas	111	1982
5,852,088 Nanoporous ceramics with catalytic functionality	38	1995
FLAME-SPRAY INDUSTRIES, INC. (2)
6,139,913 Kinetic spray coating method and apparatus	93	1999
6,283,386 Kinetic spray coating apparatus	70	2000
GENERAL ELECTRIC COMPANY (2)
4,237,559 Bone implant embodying a composite high and low density fired ceramic construction	62	1979
6,180,184 Thermal barrier coatings having an improved columnar microstructure	25	1997
HARBOR MEDICAL DEVICES, INC. (2)
5,447,724 Medical device polymer	365	1993
5,569,463 Medical device polymer	280	1995
HITACHI, LTD. (2)
2005/0186,696 Gas flowmeter and manufacturing method thereof		2005
2005/0186,696 Gas flowmeter and manufacturing method thereof		2005
ICON MEDICAL CORP. (2)
2007/0123,973 Biodegradable device	35	2006
2010/0042,206 BIOABSORBABLE COATINGS FOR MEDICAL DEVICES	37	2009
INFRAMAT CORPORATION (2)
2008/0069,854 MEDICAL DEVICES AND METHODS OF MAKING AND USING	37	2007
2008/0124,373 LUMEN - SUPPORTING DEVICES AND METHODS OF MAKING AND USING	35	2007
INTERNATIONAL BUSINESS MACHINES CORPORATION (2)
5,693,928 Method for producing a diffusion barrier and polymeric article having a diffusion barrier	38	1996
6,962,822 Discrete nano-textured structures in biomolecular arrays, and method of use	35	2002
KIPS BAY MEDICAL, INC. (2)
2005/0055,085 Implantable medical devices having recesses	38	2003
2006/0184,235 Implantable medical devices having recesses	34	2006
LUCENT TECHNOLOGIES INC. (2)
5,681,196 Spaced-gate emission device and method for making same	33	1995
6,504,292 Field emitting device comprising metallized nanostructures and method for making the same	107	1999
MEDTRONIC AVE, INC. (2)
5,290,585 Lubricious hydrogel coatings	102	1992
6,206,915 Drug storing and metering stent	138	1998
NANOSYS, INC. (2)
2005/0038,498 Medical device applications of nanostructured surfaces	99	2004
2005/0221,072 Medical device applications of nanostructured surfaces	87	2005
NICAST LTD. (2)
2004/0030,377 Medicated polymer-coated stent assembly	44	2003
7,244,272 Vascular prosthesis and method for production thereof	38	2005
NORMAN NOBLE, INC., (2)
6,709,451 Channeled vascular stent apparatus and method	55	2000
2004/0181,275 Channeled vascular stent apparatus and method	33	2004
NOVOSTENT CORPORATION (2)
2004/0122,504 Vascular prosthesis and methods of use	39	2003
2004/0158,308 Delivery catheter for ribbon-type prosthesis and methods of use	33	2004
ORBUSNEICH MEDICAL, INC. (2)
2004/0039,441 Drug eluting implantable medical device	58	2003
2007/0129,789 Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device	34	2006
PFIZER INC. (2)
2005/0137,679 Modified stent useful for delivery of drugs along stent strut	36	2004
2005/0137,684 Stent with therapeutically active drug coated thereon	36	2004
PRECISION VASCULAR SYSTEMS, INC. (2)
6,214,042 Micro-machined stent for vessels, body ducts and the like	78	1998
6,063,101 Stent apparatus and method	168	1998
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (2)
5,587,507 Synthesis of tyrosine derived diphenol monomers	76	1995
6,475,477 Radio-opaque polymer biomaterials	65	2000
SPECTRA-PHYSICS, INC. (2)
2004/0000,540 Laser texturing of surfaces for biomedical implants	37	2003
2005/0211,680 Systems and methods for laser texturing of surfaces of a substrate	52	2005
SPIRE CORPORATION (2)
5,474,797 Bactericidal coatings for implants	82	1994
7,771,773 Nano-crystalline, homo-metallic, protective coatings	34	2006
STENT TECH, INC. (2)
5,858,556 Multilayer composite tubular structure and method of making	218	1997
2002/0133,222 Expandable stent having a plurality of interconnected expansion modules	40	2002
SYNTHEON, LLC (2)
6,527,938 Method for microporous surface modification of implantable metallic medical articles	69	2001
2003/0108,659 Implantable metallic medical articles having microporous surface structure	46	2003
TERUMO KABUSHIKI KAISHA (2)
6,833,004 Stent	58	2002
2003/0181,975 Stent	37	2003
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (2)
7,048,939 Methods for the inhibition of neointima formation	37	2002
7,056,339 Drug delivery platform	39	2002
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (2)
5,830,480 Stabilization of sol-gel derived silica-based glass	35	1996
2005/0019,265 Polymersomes incorporating highly emissive probes	37	2004
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (2)
5,380,298 Medical device with infection preventing feature	64	1993
6,025,036 Method of producing a film coating by matrix assisted pulsed laser deposition	55	1997
THORATEC CORPORATION (2)
6,327,504 Transcutaneous energy transfer with circuitry arranged to avoid overheating	47	2000
6,752,826 Layered stent-graft and methods of making the same	146	2001
WARSAW ORTHOPEDIC, INC. (2)
6,323,146 Synthetic biomaterial compound of calcium phosphate phases particularly adapted for supporting bone cell activity	86	1998
2006/0229,715 Implants incorporating nanotubes and methods for producing the same	25	2005
WORLD HEART CORPORATION (2)
4,665,896 Power supply for body implant and method of use	115	1985
6,270,831 Method and apparatus for providing a conductive, amorphous non-stick coating	110	1998
XTENT, INC. (2)
2004/0243,217 Expandable stent	58	2004
2005/0228,477 Topographic coatings and coating methods for medical devices	55	2005
3M INNOVATIVE PROPERTIES COMPANY (1)
2002/0095,871 Method of making ceramic aggregate particles	28	2001
ADVANCED LASER APPLICATIONS HOLDING S.A. (1)
2004/0006,382 Intraluminar perforated radially expandable drug delivery prosthesis	52	2003
AIR PRODUCTS AND CHEMICALS, INC. (1)
2002/0142,579 ORGANOSILICON PRECURSORS FOR INTERLAYER DIELECTRIC FILMS WITH LOW DIELECTRIC CONSTANTS	41	2001
AITA, CAROLYN (1)
6,869,701 Self-repairing ceramic coatings	38	1999
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (1)
5,405,367 Structure and method of manufacture of an implantable microstimulator	243	1993
ALLIEDSIGNAL INC. (1)
6,022,812 Vapor deposition routes to nanoporous silica	36	1998
ALZA CORPORATION (1)
6,071,305 Directional drug delivery stent and method of use	317	1997
ANELVA CORPORATION (1)
6,878,249 High frequency sputtering device	33	2001
APPLIED MATERIALS, INC. (1)
6,367,412 Porous ceramic liner for a plasma source	42	2000
APPLIED MEDICAL RESOURCES CORPORATION (1)
2005/0113,936 Surface treatments and modifications using nanostructure materials	50	2004
APPLIED MICROSTRUCTURES, INC. (1)
2006/0088,666 Controlled vapor deposition of biocompatible coatings over surface-treated substrates	39	2005
AQUAMARIJN HOLDING B.V. (1)
2004/0028,875 Method of making a product with a micro or nano sized structure and product	98	2003
ASTELLAS PHARMA INC. (1)
2004/0117,008 Medical implants containing FK506 (tacrolimus), methods of making and methods of use thereof	53	2003
AZMED, LTD. (1)
2005/0251,245 Methods and apparatus with porous materials	37	2004
B. BRAUN-SSC AG (1)
4,902,290 Process for the preparation of a vessel prosthesis impregnated with crosslinked gelatin	76	1988
BADARI NAYANAN NAGARADA GADDE (1)
2004/0117,005 Stent with drug-delivery system	35	2004
BASF CORPORATION (1)
5,686,499 Polyurethane foams containing high levels of silicone-containing surfactant polymer to improve flame retardance and aged K-factors	23	1995
BATTELLE-INSTITUT E.V. (1)
4,202,055 Anchorage for highly stressed endoprostheses	96	1977
BAYER MATERIALSCIENCE AG (1)
6,599,558 Treating metal surfaces to enhance bio-compatibility and/or physical characteristics	46	1999
BEST MEDICAL INTERNATIONAL, INC. (1)
6,709,397 Scanning probe	42	2002
BIOCER ENTWICKLUNGS GMBH (1)
2009/0317,766 Structured coatings for implants and process for the preparation thereof	18	2007
BIOSENSORS INTERNATIONAL USA (1)
2003/0088,307 Potent coatings for stents	110	2002
BIOTRONIK AG (1)
6,287,332 Implantable, bioresorbable vessel wall support, in particular coronary stent	172	1999
BIOTRONIK IV PATENT AG (1)
2006/0052,864 Endoprosthesis comprising a magnesium alloy	39	2005
BIOTRONIK VI PATENT AG (1)
2006/0052,863 Endoprosthesis comprising a magnesium alloy	39	2005
BLERSCH, JUERGEN, DR. (1)
2005/0079,201 Implants with functionalized carbon surfaces	27	2004
BLUE MEDICAL DEVICES B.V. (1)
2008/0050,413 Medical stent provided with a combination of melatonin and paclitaxel	34	2006
BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (1)
7,311,727 Encased stent	40	2004
BODYCOTE ORTECH INC. (1)
4,475,972 Implantable material	142	1982
BOSTON SCIENTIFIC LIMITED (1)
6,335,029 Polymeric coatings for controlled delivery of active agents	333	1998
BRIDGE BLOOD TECHNOLOGIES LLC, NEW YORK LIMITED LIABILITY COMPANY (1)
5,322,520 Iontophoretic structure for medical devices	154	1992
CALCITEC, INC. (1)
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OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (54)
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2005/0271,703 Controlled release bioactive agent delivery device	37	2005
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2007/0106,347 Portable medical and cosmetic photon emission adjustment device and method using the same	34	2005
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2006/0280,770 Coating for implantable devices and a method of forming the same	36	2006
2008/0262,607 Implant Particularly Stent, and Method For the Production of Such an Implant	18	2006
2007/0198,081 Poly(butylmethacrylate) and rapamycin coated stent	22	2006
2007/0207,186 Tear and abrasion resistant expanded material and reinforcement	103	2007
2008/0171,929 METHOD FOR STANDARDIZING SPACING BETWEEN ELECTRODES, AND MEDICAL TAPE ELECTRODES	38	2008

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