US Patent No: 8,066,973
Number of patents in Portfolio can not be more than 2000
Nanoparticulate probe for in vivo monitoring of tissue oxygenation
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Nov 29, 2011
Issued date -
Mar 1, 2006
filing date -
11/365,798
serial no -
In Force
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Abstract
A new class of micro- and nano- particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.
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First Claim
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 4,996,311 Octasubstituted lithium phthalocyanines, their method of preparation and their use in EPR (electronic paramagnetic resonance) magnetometry | 7 | 1989 | |
| 5,112,597 Radical lithium phthalocyanine crystals, their preparation process and their use for the in vivo determination of molecular oxygen | 6 | 1991 | |
| 5,258,313 Process for the detection or determination of oxygen by EPR spectrometry using radical lithium phthalocyanines and composition usable for in vivo determination | 3 | 1991 | |
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| 7,662,362 Nanoparticulate probe for in vivo monitoring of tissue oxygenation | 3 | 2004 | |
| 2005/0203,292 Nanoparticulate probe for in vivo monitoring of tissue oxygenation | 1 | 2004 | |
| 2010/0172,843 NANOPARTICULATE PROBE FOR IN VIVO MONITORING OF TISSUE OXYGENATION | 1 | 2010 | |
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| 5,494,030 Apparatus and methodology for determining oxygen in biological systems | 70 | 1993 | |
| 5,706,805 Apparatus and methodology for determining oxygen tension in biological systems | 7 | 1995 | |
| 5,833,601 Methodology for determining oxygen in biological systems | 77 | 1997 | |
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| 5,765,562 Method for determining oxygen concentration using magnetic resonance imaging | 5 | 1995 | |
| 6,256,527 Method for determining oxygen concentration | 4 | 1998 | |
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| 5,607,762 Ink-ribbons comprising IR-absorbing compounds | 29 | 1995 | |
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| 5,045,440 Stabilization of optical information storage media by incorporation of nitrogen containing compounds | 5 | 1990 | |
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| 6,060,598 Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding | 5 | 1997 | |
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| 6,391,646 Paramagnetic resonance method for quantitative determination of molecular oxygen and its isotopes | 2 | 1999 | |
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| 5,965,598 Zinc-phthalocyanines and corresponding conjugates, their preparation and use in photodynamic therapy and as diagnostic agents | 8 | 1998 | |
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| 6,573,720 Resonant structure for spatial and spectral-spatial imaging of free radical spin probes using radiofrequency time domain electron paramagnetic resonance spectroscopy | 4 | 2000 | |
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| 5,550,050 Method for implanting encapsulated cells in a host | 51 | 1994 | |
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| 6,108,574 Overhauser enhanced magnetic resonance imaging technique (OMRI or PEDRI or ESREMRI) | 4 | 1998 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 3.5 Year Payment | $1600.00 | $800.00 | $400.00 | May 29, 2015 |
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | May 29, 2019 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | May 29, 2023 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 3.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |