US Patent No: 8,066,973

Number of patents in Portfolio can not be more than 2000

Nanoparticulate probe for in vivo monitoring of tissue oxygenation

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ALSO PUBLISHED AS: 20070041909
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Abstract

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A new class of micro- and nano- particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONCOLUMBUS, OH850

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kuppusamy, Periannan New Albany, OH 9 12
Kutala, Vijay - 3 2
Kwiatkowski, Pawel Dublin, OH 4 7
Zweier, Jay L Blacklick, OH 11 17

Cited Art Landscape

Patent Info (Count) # Cites Year
 
COMMISSARIAT A L'ENERGIE ATOMIQUE (3)
4,996,311 Octasubstituted lithium phthalocyanines, their method of preparation and their use in EPR (electronic paramagnetic resonance) magnetometry 10 1989
5,112,597 Radical lithium phthalocyanine crystals, their preparation process and their use for the in vivo determination of molecular oxygen 8 1991
5,258,313 Process for the detection or determination of oxygen by EPR spectrometry using radical lithium phthalocyanines and composition usable for in vivo determination 5 1991
 
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (3)
7,662,362 Nanoparticulate probe for in vivo monitoring of tissue oxygenation 5 2004
2005/0203,292 Nanoparticulate probe for in vivo monitoring of tissue oxygenation 3 2004
2010/0172,843 NANOPARTICULATE PROBE FOR IN VIVO MONITORING OF TISSUE OXYGENATION 2 2010
 
TRUSTEES OF DARTMOUTH COLLEGE (3)
5,494,030 Apparatus and methodology for determining oxygen in biological systems 83 1993
5,706,805 Apparatus and methodology for determining oxygen tension in biological systems 11 1995
5,833,601 Methodology for determining oxygen in biological systems 81 1997
 
GE HEALTHCARE AS (2)
5,765,562 Method for determining oxygen concentration using magnetic resonance imaging 7 1995
6,256,527 Method for determining oxygen concentration 6 1998
 
BASF AKTIENGESELLSCHAFT (1)
5,607,762 Ink-ribbons comprising IR-absorbing compounds 31 1995
 
HOECHST CELANESE CORPORATION (1)
5,045,440 Stabilization of optical information storage media by incorporation of nitrogen containing compounds 7 1990
 
Hyperion, Inc. (1)
6,060,598 Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding 7 1997
 
Khangulov, Sergei (1)
6,391,646 Paramagnetic resonance method for quantitative determination of molecular oxygen and its isotopes 4 1999
 
Molteni L. & C. dei Fratelli Alitti Societa di esercizio S.p.A. (1)
5,965,598 Zinc-phthalocyanines and corresponding conjugates, their preparation and use in photodynamic therapy and as diagnostic agents 11 1998
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
6,573,720 Resonant structure for spatial and spectral-spatial imaging of free radical spin probes using radiofrequency time domain electron paramagnetic resonance spectroscopy 6 2000
 
NEUROTECH USA, INC. (1)
5,550,050 Method for implanting encapsulated cells in a host 56 1994
 
NYCOMED IMAGING AS (1)
6,108,574 Overhauser enhanced magnetic resonance imaging technique (OMRI or PEDRI or ESREMRI) 6 1998

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
GIVEN IMAGING LTD. (1)
8,582,853 Device, system and method for automatic detection of contractile activity in an image frame 0 2013
 
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (1)
8,569,482 Nanoparticulate probe for in vivo monitoring of tissue oxygenation 0 2011

Maintenance Fees

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3.5 Year Payment $1600.00 $800.00 $400.00 May 29, 2015
7.5 Year Payment $3600.00 $1800.00 $900.00 May 29, 2019
11.5 Year Payment $7400.00 $3700.00 $1850.00 May 29, 2023
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Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00