Nanoparticulate probe for in vivo monitoring of tissue oxygenation

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8066973
APP PUB NO 20070041909A1
SERIAL NO

11365798

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A new class of micro- and nano- particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
THE OHIO STATE UNIVERSITYCOLUMBUS, OH495

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kuppusamy, Periannan New Albany, US 9 21
Kutala, Vijay Columbus, US 2 6
Kwiatkowski, Pawel Dublin, US 2 18
Zweier, Jay L Columbus, US 7 35

Cited Art Landscape

Patent Info (Count) # Cites Year
 
HOECHST CELANESE CORPORATION (1)
5045440 Stabilization of optical information storage media by incorporation of nitrogen containing compounds 7 1990
 
Khangulov, Sergei (1)
6391646 Paramagnetic resonance method for quantitative determination of molecular oxygen and its isotopes 5 1999
 
THE OHIO STATE UNIVERSITY (3)
7662362 Nanoparticulate probe for in vivo monitoring of tissue oxygenation 8 2004
2005/0203,292 Nanoparticulate probe for in vivo monitoring of tissue oxygenation 5 2004
2010/0172,843 NANOPARTICULATE PROBE FOR IN VIVO MONITORING OF TISSUE OXYGENATION 3 2010
 
NYCOMED IMAGING AS (1)
6108574 Overhauser enhanced magnetic resonance imaging technique (OMRI or PEDRI or ESREMRI) 8 1998
 
TRUSTEES OF DARTMOUTH COLLEGE (3)
5494030 Apparatus and methodology for determining oxygen in biological systems 108 1993
5706805 Apparatus and methodology for determining oxygen tension in biological systems 15 1995
5833601 Methodology for determining oxygen in biological systems 85 1997
 
BASF AKTIENGESELLSCHAFT (1)
5607762 Ink-ribbons comprising IR-absorbing compounds 33 1995
 
NEUROTECH USA, INC. (1)
5550050 Method for implanting encapsulated cells in a host 63 1994
 
The United States of America as represented by the Department of Health and Human Services (1)
6573720 Resonant structure for spatial and spectral-spatial imaging of free radical spin probes using radiofrequency time domain electron paramagnetic resonance spectroscopy 6 2000
 
Hyperion, Inc. (1)
6060598 Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding 11 1997
 
Molteni L. & C. dei Fratelli Alitti Societa di esercizio S.p.A. (1)
5965598 Zinc-phthalocyanines and corresponding conjugates, their preparation and use in photodynamic therapy and as diagnostic agents 12 1998
 
COMMISSARIAT A L'ENERGIE ATOMIQUE (3)
4996311 Octasubstituted lithium phthalocyanines, their method of preparation and their use in EPR (electronic paramagnetic resonance) magnetometry 10 1989
5112597 Radical lithium phthalocyanine crystals, their preparation process and their use for the in vivo determination of molecular oxygen 8 1991
5258313 Process for the detection or determination of oxygen by EPR spectrometry using radical lithium phthalocyanines and composition usable for in vivo determination 5 1991
 
GE HEALTHCARE AS (2)
5765562 Method for determining oxygen concentration using magnetic resonance imaging 7 1995
6256527 Method for determining oxygen concentration 6 1998
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
GIVEN IMAGING LTD. (1)
* 8582853 Device, system and method for automatic detection of contractile activity in an image frame 0 2013
 
THE OHIO STATE UNIVERSITY (1)
8569482 Nanoparticulate probe for in vivo monitoring of tissue oxygenation 1 2011
 
TRUSTEES OF DARTMOUTH COLLEGE (2)
* 8954131 Magnetic particle imaging (MPI) system and method for use of iron-based nanoparticles in imaging and diagnosis 0 2010
* 2011/0098,558 SYSTEM AND METHOD FOR USE OF NANOPARTICLES IN IMAGING AND DIAGNOSIS 5 2010
* Cited By Examiner

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