Therapeutic inhibitor of vascular smooth muscle cells

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8067022
APP PUB NO 20020013275A1
SERIAL NO

09910388

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Abstract

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Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOSTON SCIENTIFIC SCIMED, INC.MAPLE GROVE, MN5261

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anderson, Peter G Birmingham, US 15 1101
Kunz, Lawrence L Sammamish, US 30 2614

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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5453442 Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease 28 1994
5567713 Hypoglycemic agents 19 1995
5489587 Benzofurans used to inhibit bone loss 21 1995
5571808 Method for treating smoking-related bone loss 10 1995
5484808 Methods of inhibiting cell-cell adhesion 33 1995
5510370 Parathyroid hormone and raloxifene for increasing bone mass 67 1995
5525624 Non-peptide tachykinin receptor antagonists to treat psycological disorder 22 1995
5686467 Methods of inhibiting imperfect tissue repair 12 1995
5686476 Methods of inhibiting Alzheimer's Disease 24 1995
5610166 Methods for inhibiting angiogenesis 17 1995
5563054 Process for preparation of benzo[B]thiophene glucuronides 14 1995
5462937 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 32 1995
5492926 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 21 1995
5496851 Methods of inhibiting cell-cell adhesion 18 1995
5508292 Methods of inhibiting thrombin 22 1995
5534527 Methods for inhibiting bone loss by treating with aroylbenzothiophenes and estrogen 28 1995
5610168 Methods of use for inhibiting bone loss and lowering serum cholesterol 13 1995
5641790 Methods of use for inhibiting bone loss and lowering serum cholesterol 25 1995
5688813 Methods of inhibiting thrombin 12 1995
5484798 Benzothiopene compounds, compositions, and method of inhibiting restenosis 35 1995
5492921 Benzothiophene compounds, compositions, and methods for inhibiting aortal smooth muscle proliferation 11 1995
5484795 Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting restenosis 40 1995
5484796 Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting aortal smooth muscle cell proliferation 14 1995
5484797 Naphthly compounds, intermediates, processes, compositions, and method for inhibiting endometrosis 18 1995
5622975 Methods for inhibiting vascular smooth muscle cell migration 27 1995
5492922 Benzothiophene compounds intermediate compositions and methods for inhibiting aortal smooth muscle proliferation 53 1995
5521172 Methods for lowering serum cholesterol 7 1995
5552433 Method for lowering serum cholesterol 8 1995
5556876 Methods for lowering serum cholesterol 5 1995
5652259 Methods of inhibiting Alzheimer's disease 11 1996
5726186 Pentacyclic compounds, intermediates, processes, compositions, and methods 10 1996
5747510 Pharmaceutical unit dosage formulations 20 1997
 
NOVO PHARMACEUTICAL CORPORATION (1)
5189046 Protein kinase C modulators 45 1991
 
ORION-YHTYMA OY (1)
5491173 Tri-phenyl alkene derivatives and their preparation and use 50 1994
 
Fidia S.p.A. (1)
5416205 New esters of alginic acid 15 1993
 
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (1)
5126348 Bioavailability enhancers 26 1989
 
JOHNSON MATTHEY, INC. (1)
5100885 Copper radiosensitizers 19 1989
 
CENTOCOR, INC. (1)
5026537 Methods for imaging atherosclerotic plaque 54 1989
 
MERCK SHARP & DOHME CORP. (1)
5441734 Metal-interferon-alpha crystals 44 1993
 
Elizabeth-Hata International, Inc. (1)
5391378 Two-part medicinal tablet and method of manufacture 34 1993
 
CORDIS CORPORATION (10)
4739762 Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft 1256 1986
5102417 Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft 985 1988
4994071 Bifurcating stent apparatus and method 1047 1989
5049132 Balloon catheter for delivering therapeutic agents 410 1990
5213576 Therapeutic porous balloon catheter 332 1991
6146358 Method and apparatus for delivery of therapeutic agent 217 1992
5486357 Radiofrequency plasma biocompatibility treatment of inside surfaces 33 1993
5356433 Biocompatible metal surfaces 371 1993
5863285 Balloon catheter with radioactive means 78 1997
2004/0236,416 Increased biocompatibility of implantable medical devices 75 2004
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (3)
5342926 Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport 15 1993
5407658 Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport 16 1994
5583153 Use of taxol in the treatment of rheumatoid arthritis 41 1994
 
Health Maintenance Programs, Inc. (1)
5326757 Pharmaceutically active antioxidant containing composition and the method of its use to prevent and treat restenosis following angioplasty 83 1993
 
CONSIGLIO NAZIONALE DELLE RICERCHE (1)
4767758 Pharmaceutical compositions containing thiophene compounds, and new thiophene compounds 13 1987
 
QUADRA LOGIC TECHNOLOGIES INC. (1)
5422362 Method to inhibit restenosis 74 1993
 
UNIVERSITY OF WASHINGTON (1)
5521191 Method for treatment of arterial stenosis 21 1994
 
OLYMPUS OPTICAL CO., LTD. (1)
5318779 Drug-impregnated ceramic 33 1990
 
ORION CORPORATION (3)
4696949 Novel tri-phenyl alkane and alkene derivatives and their preparation and use 54 1986
4996225 Tri-phenyl alkane derivatives and their oestrogenic, anti-oestrogenic and progestanic uses 33 1989
5605700 Topical administration of toremifene and its metabolites 28 1994
 
DUKE UNIVERSITY (1)
5527337 Bioabsorbable stent and method of making the same 476 1994
 
GENENTECH, INC. (8)
5108989 Method of predisposing mammals to accelerated tissue repair 68 1990
5208019 Use of gamma-interferon for the treatment of vascular stenosis 40 1991
5118791 Biologically active polypeptides based on transforming growth factor-.beta. 34 1991
5216126 Receptor polypeptides and their production and uses 81 1991
5166191 Use of relaxin in cardiovascular therapy 38 1991
5268455 Process for making biologically active polypeptides based on transforming growth factor-.beta.sequences 20 1992
5284763 Nucleic acid encoding TGF-.beta. and its uses 37 1992
5482851 Nucleic acid encoding TGF-.beta. and its uses 8 1993
 
HEMAGEN/PFC A LIMITED PARTNERSHIP OF CALIFORNIA (1)
5304325 Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use 50 1991
 
BIOCOMPATIBLES UK LIMITED (1)
5496581 Polymeric coating 26 1993
 
HERITAGE TECHNOLOGIES, LLC (1)
5451414 Micronutrient supplement 12 1994
 
ENDORECHERCHE, A CANADIAN CORPORATION (1)
5395842 Anti-estrogenic compounds and compositions 115 1991
 
ENDOTEX INTERNATIONAL SYSTEMS, INC. (1)
5824054 Coiled sheet graft stent and methods of making and use 195 1997
 
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5514154 Expandable stents 787 1994
6656216 Composite stent with regioselective material 220 2001
 
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (2)
5260224 Therapeutic uses of actin-binding compounds 39 1991
5358844 Preservation of blood platelets 43 1993
 
MATRIX PHARMACEUTICAL, INC. (1)
5597578 TGF-.beta. protein compositions for inhibition of cell proliferation 38 1994
 
VALEANT INTERNATIONAL BERMUDA (1)
5439689 Diltiazem formulation 71 1993
 
SRI INTERNATIONAL (1)
5354562 Process for preparing micronized polypeptide drugs 140 1993
 
Zinpro Corporation (2)
4900561 Copper complexes of alpha-amino acids that contain terminal amino groups, and their use as nutritional supplements 31 1989
4956188 Copper complexes with alpha hydroxy organic acids and their use as nutritional supplements 29 1989
 
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4954126 Prosthesis comprising an expansible or contractile tubular body 877 1989
 
ACDS TECHNOLOGIES, INC. (1)
5424331 Pharmaceutical compositions and dietary soybean food products for the prevention of osteoporosis 84 1994
 
ANGIOTECH PHARMACEUTICALS, INC. (1)
6544544 Anti-angiogenic compositions and methods of use 180 2001
 
PHARMETRIX, MENLO PARK (1)
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5716981 Anti-angiogenic compositions and methods of use 824 1995
 
CARDINAL HEALTH SWITZERLAND 515 GMBH (2)
5195984 Expandable intraluminal graft 716 1991
5902332 Expandable intraluminal graft 217 1992
 
NeoRx Corporation (2)
4906452 Trichothecene conjugates and methods of use 31 1988
5066789 Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages 40 1989
 
ALKERMES PHARMA IRELAND LIMITED (1)
5346702 Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization 118 1992
 
NIPPON KAYAKU KABUSHIKI KAISHA (1)
5296492 Certain chroman derivatives useful for treating symptoms caused by contraction of smooth muscles, circulatory diseases or epilepsy 28 1992
 
CARDIOPULMONICS, A CORP OF UTAH (1)
5338770 Gas permeable thrombo-resistant coatings and methods of manufacture 71 1990
 
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (1)
4491574 Reduction of high dose aspirin toxicity by dietary vitamin A 26 1983
 
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (2)
5362424 Microencapsulation for controlled oral drug delivery system 68 1991
5415619 Method of manufacturing a vascular graft impregnated with polysaccharide derivatives 55 1993
 
BAYLOR COLLEGE OF MEDICINE (1)
5216024 Cell growth inhibitors and methods of treating cancer and cell proliferative diseases 26 1988
 
INTERMEDICAT GMBH, GERLISWILSTRASSE 74, CH-6020 EMMENBRUCKE, SWITZERLAND, (1)
4784659 Vessel and prosthesis impregnated with diisocyanate crosslinked gelatin 97 1987
 
NoeRx Corporation (1)
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WYETH (15)
5288711 Method of treating hyperproliferative vascular disease 180 1992
5252579 Macrocyclic immunomodulators 96 1993
5302584 Carbamates of rapamycin 114 1993
5387680 C-22 ring stabilized rapamycin derivatives 47 1993
5411967 Carbamates of rapamycin 64 1994
5504091 Biotin esters of rapamycin 78 1994
5516781 Method of treating restenosis with rapamycin 226 1994
5491159 2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-oxazoles as anti-atherosclerotic agents 19 1994
5498775 Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation 33 1994
5563145 Rapamycin 42-oximes and hydroxylamines 71 1994
5525610 42-Epi-rapamycin and pharmaceutical compositions thereof 58 1995
5563146 Method of treating hyperproliferative vascular disease 136 1995
5646160 Method of treating hyperproliferative vascular disease with rapamycin and mycophenolic acid 105 1995
5665728 Method of treating hyperproliferative vascular disease 88 1995
5677295 Rapamycin 42-oximes and hydroxylamines 9 1996
 
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5332584 Microcapsules 45 1991
 
ENDORECHERCHE, INC. (1)
5393785 Therapeutic antiestrogens 37 1992
 
Celtrix Pharmaceuticals, Inc. (4)
5571714 Monoclonal antibodies which bind both transforming growth factors .beta.1 and .beta.2 and methods of use 62 1991
5462925 Transforming growth factor .beta.2,3 18 1992
5658883 Biologically active TGF-.beta.1 peptides 8 1995
5767079 Method of treating ophthalmic disorders using TGF -.beta. 62 1996
 
BOSTON SCIENTIFIC SCIMED, INC. (33)
4994033 Intravascular drug delivery dilatation catheter 481 1989
5009659 Fiber tip atherectomy catheter 240 1989
5064435 Self-expanding prosthesis having stable axial length 1215 1990
5222971 Temporary stent and methods for use and manufacture 433 1990
5304121 Drug delivery system making use of a hydrogel polymer coating 716 1991
5197977 Drug delivery collagen-impregnated synthetic vascular graft 407 1992
5234456 Hydrophilic stent 587 1992
5449382 Minimally invasive bioactivated endoprosthesis for vessel repair 447 1994
6515009 Therapeutic inhibitor of vascular smooth muscle cells 98 1995
5811447 Therapeutic inhibitor of vascular smooth muscle cells 225 1995
5578075 Minimally invasive bioactivated endoprosthesis for vessel repair 286 1995
6171609 Therapeutic inhibitor of vascular smooth muscle cells 216 1995
5837313 Drug release stent coating process 802 1996
6120536 Medical devices with long term non-thrombogenic coatings 688 1996
* 5733925 Therapeutic inhibitor of vascular smooth muscle cells 487 1996
5735897 Intravascular stent pump 362 1997
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6306421 Therapeutic inhibitor of vascular smooth muscle cells 111 1997
5980972 Method of applying drug-release coatings 540 1997
6099562 Drug coating with topcoat 643 1997
2002/0032,477 DRUG RELEASE COATED STENT 121 1998
6129757 Implantable members for receiving therapeutically useful compositions 33 1998
6358989 Therapeutic inhibitor of vascular smooth muscle cells 55 1999
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6783543 Intravascular stent with increasing coating retaining capacity 143 2001
6491938 Therapeutic inhibitor of vascular smooth muscle cells 116 2001
6599928 Therapeutic inhibitor of vascular smooth muscle cells 60 2001
2002/0013,275 Therapeutic inhibitor of vascular smooth muscle cells 22 2001
6569441 Therapeutic inhibitor of vascular smooth muscle cells 110 2001
2002/0091,433 Drug release coated stent 264 2001
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6656162 Implantable drug delivery stents 240 2002
6720350 Therapeutic inhibitor of vascular smooth muscle cells 98 2002
 
BOSTON SCIENTIFIC CORPORATION (2)
4762129 Dilatation catheter 686 1986
4922905 Dilatation catheter 742 1988
 
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (2)
5216115 Polyarylate containing derivatives of the natural amino acid L-tyrosine 81 1992
5877224 Polymeric drug formulations 305 1995
 
WYETH LLC (1)
5362718 Rapamycin hydroxyesters 181 1994
 
LUDWIG INSTITUTE FOR CANCER RESEARCH, A CORP OF NY (1)
5229495 Substantially pure receptor like TGF-.beta. 1 binding molecules and uses thereof 48 1991
 
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (2)
4973601 Control of insects by fungal tremorgenic mycotoxins 17 1988
5019504 Production of taxol or taxol-like compounds in cell culture 79 1989
 
MEDINOL LTD. (5)
5733303 Flexible expandable stent 405 1995
5843120 Flexible-expandable stent 290 1997
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6461381 Flexible expandable stent 67 1999
6443982 Flexible expandable stent 85 2000
 
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5464450 Biodegradable drug delivery vascular stent 322 1994
5551954 Biodegradable drug delivery vascular stent 329 1994
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5262451 Multifunctional thrombo-resistant coatings and methods of manufacture 68 1988
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Quanam Medical Corporation (1)
6168619 Intravascular stent having a coaxial polymer member and end sleeves 142 1998
 
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5232911 Mixture of a non-covalent heterodimer complex and a basic amphiphatic peptide as cytotoxic agent 24 1991
 
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (2)
4959355 Method of inhibiting osmotic water flow 15 1987
5019096 Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same 665 1988
 
The United States of America as represented by the United States Department of Energy (1)
5185260 Method for distinguishing normal and transformed cells using G1 kinase inhibitors 48 1991
 
KLINGE PHARMA GMBH (2)
5047431 1,1,2-triphenylbut-1-ene derivatives 72 1990
5254594 Remedies for bone diseases 72 1992
 
The Hope Heart Institute (1)
5401730 Method for reducing platelet aggregation 38 1993
 
SULZER CARBOMEDICS INC. (1)
4689046 Heart valve prosthesis 47 1985
 
N.V. ORGANON (1)
5496557 Article for the controlled delivery of an active substance, comprising a hollow space fully enclosed by a wall and filled in full or in part with one or more active substances 43 1993
 
EMORY UNIVERSITY (3)
5399352 Device for local drug delivery and methods for using the same 70 1993
5383928 Stent sheath for local drug delivery 416 1993
5523092 Device for local drug delivery and methods for using the same 180 1994
 
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AMO UPPSALA AB (1)
5576345 Method and means for inhibiting posterior capsule opacification 23 1996
 
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5262319 Method for obtaining bone marrow free of tumor cells using transforming growth factor .beta.3 28 1990
5635489 Methods of prevention of oral mucositis with transforming growth factor .beta. 15 1995
 
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5873904 Silver implantable medical device 901 1997
 
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5092877 Radially expandable endoprosthesis 429 1990
5226913 Method of making a radially expandable prosthesis 411 1992
 
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5167960 Hirudin-coated biocompatible substance 77 1988
 
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5496346 Reinforced balloon dilatation catheter with slitted exchange sleeve and method 412 1993
5423885 Stent capable of attachment within a body lumen 478 1993
5443458 Multilayered biodegradable stent and method of manufacture 398 1993
5421955 Expandable stents and method for making same 741 1994
5629077 Biodegradable mesh and film stent 306 1994
5637113 Polymer film for wrapping a stent structure 485 1994
5605696 Drug loaded polymeric material and method of manufacture 707 1995
5632840 Method of making metal reinforced polymer stent 261 1995
5626600 Reinforced balloon dilatation catheter with slitted exchange sleeve and method 182 1995
6066167 Expandable stents 133 1998
6488694 Stent delivery system 161 1999
6527789 Stent delivery system 117 1999
6309412 Expandable stents and method for making same 63 2000
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6432133 Expandable stents and method for making same 97 2000
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The Howard Foundation (1)
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Blendax-Werke, R. Schneider GmbH & Co. (3)
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LIFESHIELD SCIENCES LLC (1)
5053048 Thromboresistant coating 237 1990
 
Boehringer Mannheim Pharmaceuticals Corporation - SmithKline Beecham Corp., Ltd. Partnership No. 1 (1)
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Goedecke Aktiengesellschaft (1)
5043335 Indolocarbazoles and the use thereof 67 1990
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