Therapeutic inhibitor of vascular smooth muscle cells

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8067022
APP PUB NO 20020013275A1
SERIAL NO

09910388

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Abstract

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Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOSTON SCIENTIFIC SCIMED, INC.MAPLE GROVE, MN5075

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anderson, Peter G Birmingham, US 15 1079
Kunz, Lawrence L Sammamish, US 30 2552

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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5484808 Methods of inhibiting cell-cell adhesion 33 1995
5510370 Parathyroid hormone and raloxifene for increasing bone mass 67 1995
5525624 Non-peptide tachykinin receptor antagonists to treat psycological disorder 22 1995
5686467 Methods of inhibiting imperfect tissue repair 12 1995
5686476 Methods of inhibiting Alzheimer's Disease 24 1995
5610166 Methods for inhibiting angiogenesis 17 1995
5563054 Process for preparation of benzo[B]thiophene glucuronides 14 1995
5462937 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 32 1995
5492926 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 21 1995
5496851 Methods of inhibiting cell-cell adhesion 18 1995
5508292 Methods of inhibiting thrombin 22 1995
5534527 Methods for inhibiting bone loss by treating with aroylbenzothiophenes and estrogen 28 1995
5610168 Methods of use for inhibiting bone loss and lowering serum cholesterol 13 1995
5641790 Methods of use for inhibiting bone loss and lowering serum cholesterol 25 1995
5688813 Methods of inhibiting thrombin 12 1995
5484798 Benzothiopene compounds, compositions, and method of inhibiting restenosis 35 1995
5492921 Benzothiophene compounds, compositions, and methods for inhibiting aortal smooth muscle proliferation 11 1995
5484795 Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting restenosis 40 1995
5484796 Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting aortal smooth muscle cell proliferation 14 1995
5484797 Naphthly compounds, intermediates, processes, compositions, and method for inhibiting endometrosis 18 1995
5622975 Methods for inhibiting vascular smooth muscle cell migration 27 1995
5492922 Benzothiophene compounds intermediate compositions and methods for inhibiting aortal smooth muscle proliferation 47 1995
5521172 Methods for lowering serum cholesterol 7 1995
5552433 Method for lowering serum cholesterol 8 1995
5556876 Methods for lowering serum cholesterol 5 1995
5652259 Methods of inhibiting Alzheimer's disease 11 1996
5726186 Pentacyclic compounds, intermediates, processes, compositions, and methods 10 1996
5747510 Pharmaceutical unit dosage formulations 20 1997
 
NOVO PHARMACEUTICAL CORPORATION (1)
5189046 Protein kinase C modulators 45 1991
 
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5491173 Tri-phenyl alkene derivatives and their preparation and use 49 1994
 
FIDIA S.P.A. (1)
5416205 New esters of alginic acid 15 1993
 
THE REGENTS OF THE UNIVERSITY OF COLORADO (1)
5126348 Bioavailability enhancers 26 1989
 
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5100885 Copper radiosensitizers 19 1989
 
CENTOCOR, INC. (1)
5026537 Methods for imaging atherosclerotic plaque 54 1989
 
MERCK SHARP & DOHME CORP. (1)
5441734 Metal-interferon-alpha crystals 44 1993
 
Elizabeth-Hata International, Inc. (1)
5391378 Two-part medicinal tablet and method of manufacture 34 1993
 
CORDIS CORPORATION (12)
4739762 Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft 1242 1986
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4994071 Bifurcating stent apparatus and method 1039 1989
5049132 Balloon catheter for delivering therapeutic agents 408 1990
5195984 Expandable intraluminal graft 708 1991
5213576 Therapeutic porous balloon catheter 320 1991
6146358 Method and apparatus for delivery of therapeutic agent 206 1992
5902332 Expandable intraluminal graft 210 1992
5486357 Radiofrequency plasma biocompatibility treatment of inside surfaces 33 1993
5356433 Biocompatible metal surfaces 367 1993
5863285 Balloon catheter with radioactive means 77 1997
2004/0236,416 Increased biocompatibility of implantable medical devices 73 2004
 
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE (3)
5342926 Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport 15 1993
5407658 Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport 16 1994
5583153 Use of taxol in the treatment of rheumatoid arthritis 41 1994
 
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5326757 Pharmaceutically active antioxidant containing composition and the method of its use to prevent and treat restenosis following angioplasty 83 1993
 
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4767758 Pharmaceutical compositions containing thiophene compounds, and new thiophene compounds 13 1987
 
QUADRA LOGIC TECHNOLOGIES INC. (1)
5422362 Method to inhibit restenosis 70 1993
 
UNIVERSITY OF WASHINGTON (1)
5521191 Method for treatment of arterial stenosis 21 1994
 
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5318779 Drug-impregnated ceramic 32 1990
 
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4696949 Novel tri-phenyl alkane and alkene derivatives and their preparation and use 54 1986
4996225 Tri-phenyl alkane derivatives and their oestrogenic, anti-oestrogenic and progestanic uses 33 1989
5605700 Topical administration of toremifene and its metabolites 28 1994
 
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5527337 Bioabsorbable stent and method of making the same 470 1994
 
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5108989 Method of predisposing mammals to accelerated tissue repair 68 1990
5208019 Use of gamma-interferon for the treatment of vascular stenosis 40 1991
5118791 Biologically active polypeptides based on transforming growth factor-.beta. 33 1991
5216126 Receptor polypeptides and their production and uses 81 1991
5166191 Use of relaxin in cardiovascular therapy 38 1991
5268455 Process for making biologically active polypeptides based on transforming growth factor-.beta.sequences 20 1992
5284763 Nucleic acid encoding TGF-.beta. and its uses 37 1992
5482851 Nucleic acid encoding TGF-.beta. and its uses 8 1993
 
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5304325 Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use 50 1991
 
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5496581 Polymeric coating 26 1993
 
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5451414 Micronutrient supplement 10 1994
 
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5824054 Coiled sheet graft stent and methods of making and use 189 1997
 
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5260224 Therapeutic uses of actin-binding compounds 39 1991
5358844 Preservation of blood platelets 43 1993
 
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5597578 TGF-.beta. protein compositions for inhibition of cell proliferation 37 1994
 
VALEANT INTERNATIONAL BERMUDA (1)
5439689 Diltiazem formulation 65 1993
 
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5354562 Process for preparing micronized polypeptide drugs 131 1993
 
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4900561 Copper complexes of alpha-amino acids that contain terminal amino groups, and their use as nutritional supplements 29 1989
4956188 Copper complexes with alpha hydroxy organic acids and their use as nutritional supplements 29 1989
 
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4954126 Prosthesis comprising an expansible or contractile tubular body 860 1989
 
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5424331 Pharmaceutical compositions and dietary soybean food products for the prevention of osteoporosis 84 1994
 
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6110483 Adherent, flexible hydrogel and medicated coatings 361 1997
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5716981 Anti-angiogenic compositions and methods of use 812 1995
 
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4906452 Trichothecene conjugates and methods of use 31 1988
5066789 Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages 40 1989
 
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5346702 Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization 115 1992
 
NIPPON KAYAKU KABUSHIKI KAISHA (1)
5296492 Certain chroman derivatives useful for treating symptoms caused by contraction of smooth muscles, circulatory diseases or epilepsy 28 1992
 
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5338770 Gas permeable thrombo-resistant coatings and methods of manufacture 69 1990
 
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (1)
4491574 Reduction of high dose aspirin toxicity by dietary vitamin A 26 1983
 
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (2)
5362424 Microencapsulation for controlled oral drug delivery system 66 1991
5415619 Method of manufacturing a vascular graft impregnated with polysaccharide derivatives 55 1993
 
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5216024 Cell growth inhibitors and methods of treating cancer and cell proliferative diseases 26 1988
 
INTERMEDICAT GMBH, GERLISWILSTRASSE 74, CH-6020 EMMENBRUCKE, SWITZERLAND, (1)
4784659 Vessel and prosthesis impregnated with diisocyanate crosslinked gelatin 97 1987
 
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5288711 Method of treating hyperproliferative vascular disease 175 1992
5252579 Macrocyclic immunomodulators 94 1993
5302584 Carbamates of rapamycin 110 1993
5387680 C-22 ring stabilized rapamycin derivatives 45 1993
5411967 Carbamates of rapamycin 61 1994
5504091 Biotin esters of rapamycin 75 1994
5516781 Method of treating restenosis with rapamycin 224 1994
5491159 2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-oxazoles as anti-atherosclerotic agents 19 1994
5498775 Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation 33 1994
5563145 Rapamycin 42-oximes and hydroxylamines 68 1994
5525610 42-Epi-rapamycin and pharmaceutical compositions thereof 55 1995
5563146 Method of treating hyperproliferative vascular disease 134 1995
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5665728 Method of treating hyperproliferative vascular disease 88 1995
5677295 Rapamycin 42-oximes and hydroxylamines 9 1996
 
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5393785 Therapeutic antiestrogens 37 1992
 
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5658883 Biologically active TGF-.beta.1 peptides 8 1995
5767079 Method of treating ophthalmic disorders using TGF -.beta. 60 1996
 
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5009659 Fiber tip atherectomy catheter 231 1989
5064435 Self-expanding prosthesis having stable axial length 1196 1990
5222971 Temporary stent and methods for use and manufacture 428 1990
5304121 Drug delivery system making use of a hydrogel polymer coating 691 1991
5197977 Drug delivery collagen-impregnated synthetic vascular graft 400 1992
5234456 Hydrophilic stent 577 1992
5449382 Minimally invasive bioactivated endoprosthesis for vessel repair 441 1994
6515009 Therapeutic inhibitor of vascular smooth muscle cells 94 1995
5811447 Therapeutic inhibitor of vascular smooth muscle cells 221 1995
5578075 Minimally invasive bioactivated endoprosthesis for vessel repair 283 1995
6171609 Therapeutic inhibitor of vascular smooth muscle cells 215 1995
5837313 Drug release stent coating process 783 1996
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5735897 Intravascular stent pump 358 1997
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6306421 Therapeutic inhibitor of vascular smooth muscle cells 107 1997
5980972 Method of applying drug-release coatings 527 1997
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6358989 Therapeutic inhibitor of vascular smooth muscle cells 55 1999
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4762129 Dilatation catheter 677 1986
4922905 Dilatation catheter 701 1988
 
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (2)
5216115 Polyarylate containing derivatives of the natural amino acid L-tyrosine 80 1992
5877224 Polymeric drug formulations 304 1995
 
WYETH LLC (1)
5362718 Rapamycin hydroxyesters 174 1994
 
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The United States of America as represented by the Secretary of Agriculture (2)
4973601 Control of insects by fungal tremorgenic mycotoxins 17 1988
5019504 Production of taxol or taxol-like compounds in cell culture 79 1989
 
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5733303 Flexible expandable stent 400 1995
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5232911 Mixture of a non-covalent heterodimer complex and a basic amphiphatic peptide as cytotoxic agent 24 1991
 
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4959355 Method of inhibiting osmotic water flow 15 1987
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The United States of America as represented by the United States Department of Energy (1)
5185260 Method for distinguishing normal and transformed cells using G1 kinase inhibitors 48 1991
 
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5047431 1,1,2-triphenylbut-1-ene derivatives 72 1990
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5399352 Device for local drug delivery and methods for using the same 70 1993
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5635489 Methods of prevention of oral mucositis with transforming growth factor .beta. 15 1995
 
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5423885 Stent capable of attachment within a body lumen 473 1993
5443458 Multilayered biodegradable stent and method of manufacture 393 1993
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5629077 Biodegradable mesh and film stent 304 1994
5637113 Polymer film for wrapping a stent structure 477 1994
5605696 Drug loaded polymeric material and method of manufacture 701 1995
5632840 Method of making metal reinforced polymer stent 259 1995
5626600 Reinforced balloon dilatation catheter with slitted exchange sleeve and method 179 1995
6066167 Expandable stents 126 1998
6488694 Stent delivery system 158 1999
6527789 Stent delivery system 112 1999
6309412 Expandable stents and method for making same 63 2000
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The Howard Foundation (1)
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THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (2)
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LIFESHIELD SCIENCES LLC (1)
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Boehringer Mannheim Pharmaceuticals Corporation - SmithKline Beecham Corp., Ltd. Partnership No. 1 (1)
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Goedecke Aktiengesellschaft (1)
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