US Patent No: 8,067,022

Number of patents in Portfolio can not be more than 2000

Therapeutic inhibitor of vascular smooth muscle cells

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ALSO PUBLISHED AS: 20020013275
ATTORNEY / AGENT: (SPONSORED)
 

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Abstract

Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOSTON SCIENTIFIC SCIMED, INC.MAPLE GROVE, MN4459

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anderson, Peter G Pittsford, NY 18 786
Kunz, Lawrence L - 32 1739

Cited Art

Patent Info (Count) # Cites Year
 
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5,445,941 Method for screening anti-osteoporosis agents 37 1993
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BOSTON SCIENTIFIC SCIMED, INC. (33)
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WYETH (15)
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MEDICAL INNOVATIVE TECHNOLOGIES R&D LIMITED PARTNERSHIP (2)
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KASINKAS, MICHAEL (1)
5,053,033 Inhibition of restenosis by ultraviolet radiation 169 1990
 
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5,436,243 Aminoanthraquinone derivatives to combat multidrug resistance 35 1993
 
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5,189,212 Triarylethylene carboxylic acids with estrogenic activity 83 1990
 
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Other [Check patent profile for assignment information] (31)
4,233,968 IUD Arrangement 25 1978
4,315,028 Method of treatment of rheumatoid arthritis 21 1979
4,487,780 Method of treatment of rheumatoid arthritis 21 1982
4,613,665 Process for covalent coupling for the production of conjugates, and polysaccharide containing products thereby obtained 116 1983
4,678,466 Internal medication delivery method and vehicle 30 1985
4,840,939 Treatment of cancer with phlorizin and its derivatives 28 1987
4,824,436 Method for the prevention of restenosis 234 1987
4,853,377 Method and composition for increasing production of serotonin 17 1988
5,002,531 Dilation catheter with an inflatable balloon 173 1988
4,968,350 Process for preparing a powder of water-insoluble polymer which can be redispersed in a liquid phase, the resulting powder and utilization thereof 41 1988
5,199,939 Radioactive catheter 258 1990
5,040,548 Angioplasty mehtod 361 1990
5,061,273 Angioplasty apparatus facilitating rapid exchanges 421 1990
5,163,952 Expandable polymeric stent with memory and delivery apparatus and method 509 1990
5,180,366 Apparatus and method for angioplasty and for preventing re-stenosis 176 1990
5,232,444 Dilatation catheter 233 1991
5,216,021 Analgesic method 11 1991
5,258,020 Method of using expandable polymeric stent with memory 258 1992
5,288,735 Treatment of glaucoma 25 1992
5,342,348 Method and device for treating and enlarging body lumens 428 1992
5,290,271 Surgical implant and method for controlled release of chemotherapeutic agents 187 1993
5,451,233 Angioplasty apparatus facilitating rapid exchanges 219 1994
5,470,876 Topical sod for treating hair loss 24 1994
5,470,883 Method of treating peripheral vasoconstriction with tamoxifen citrate 30 1994
5,693,607 Uses of TGF-.beta. receptor fragment as a therapeutic agent 23 1994
5,541,174 Analgesic method 13 1995
5,521,171 Anti-inflammatory and anti-ulcer compounds and process 11 1995
5,639,274 Integrated catheter system for balloon angioplasty and stent delivery 126 1995
5,749,888 Method of using angioplasty apparatus facilitating rapid exchanges 62 1995
6,575,993 Angioplasty apparatus facilitating rapid exchanges 66 1995
6,036,715 Angioplasty apparatus facilitating rapid exchanges 96 1997

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Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00