US Patent No: 8,067,022 - Analytics, PDF, Full Text and PAIR Access

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Therapeutic inhibitor of vascular smooth muscle cells

ALSO PUBLISHED AS: 20020013275

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Abstract

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Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOSTON SCIENTIFIC SCIMED, INC.MAPLE GROVE, MN4581

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anderson, Peter G Pittsford, NY 20 933
Kunz, Lawrence L - 37 2116

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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5,270,047 Local delivery of dipyridamole for the treatment of proliferative diseases 39 1991
5,482,949 Sulfonate derivatives of 3-aroylbenzo[b]thiophenes 53 1993
5,445,941 Method for screening anti-osteoporosis agents 37 1993
5,391,557 Methods for the treatment of peri-menopausal syndrome 44 1993
5,418,252 Method for inhibiting cartilage degradation 28 1993
5,441,964 Methods for inhibiting bone loss using substituted benzothiophene 37 1993
5,457,113 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 93 1993
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5,461,065 Methods for inhibiting endometriosis 26 1993
5,482,950 Methods for lowering serum cholesterol 16 1993
5,480,904 Methods for inhibiting uterine fibrosis 17 1993
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5,439,931 Method for increasing libido in post-menopausal women 27 1993
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5,446,053 Methods of inhibiting dysfunctional uterine bleeding 28 1993
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5,451,590 Methods of inhibiting sexual precocity 20 1993
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5,462,949 Methods of inhibiting fertility in women 24 1993
5,462,950 Methods of treating menstrual symptoms and compositions therefore 33 1993
5,492,927 Non-peptide tachykinin receptor antagonists to treat allergy 37 1993
5,521,198 Methods of inhibiting autoimmune diseases 19 1993
5,552,415 Method of inhibiting Alzheimer's Disease 32 1993
5,574,047 Methods of inhibiting imperfect tissue repair 14 1993
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5,508,292 Methods of inhibiting thrombin 22 1995
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BOSTON SCIENTIFIC SCIMED, INC. (33)
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MEDTRONIC, INC. (26)
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ADVANCED CARDIOVASCULAR SYSTEMS, INC. (20)
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WYETH (15)
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NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (11)
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4,442,119 Cyclopropyl analogs as estrogenic and anti-fertility agents 36 1982
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5,015,578 BMY-41950 antitumor antibiotic 28 1990
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ProCyte Corporation (3)
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5,342,926 Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport 15 1993
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United States Surgical Corporation (3)
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5,514,154 Expandable stents 676 1994
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ALKERMES CONTROLLED THERAPEUTICS INC. II (2)
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HOFFMANN-LA ROCHE INC. (2)
4,317,915 Novel thiophene derivatives 17 1980
4,428,963 Novel thiophene derivatives 14 1983
 
INNERDYNE, INC. (2)
5,262,451 Multifunctional thrombo-resistant coatings and methods of manufacture 66 1988
5,182,317 Multifunctional thrombo-resistant coatings and methods of manufacture 104 1991
 
KLINGE PHARMA GMBH (2)
5,047,431 1,1,2-triphenylbut-1-ene derivatives 72 1990
5,254,594 Remedies for bone diseases 71 1992
 
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (2)
5,362,424 Microencapsulation for controlled oral drug delivery system 66 1991
5,415,619 Method of manufacturing a vascular graft impregnated with polysaccharide derivatives 53 1993
 
La Jolla Cancer Research Foundation (2)
5,453,492 60 kDa transforming growth factor-.beta.-binding protein and its use to detect or purify TGF-.beta. 47 1993
5,705,609 Decorin fragments inhibiting cell regulatory factors 21 1995
 
Medical Innovative Technologies R&D Limited Partnership (2)
5,059,166 Intra-arterial stent with the capability to inhibit intimal hyperplasia 437 1989
5,176,617 Use of a stent with the capability to inhibit malignant growth in a vessel such as a biliary duct 237 1991
 
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5,340,925 Normal human growth regulatory receptor for TGF-.beta. 32 1992
 
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5,262,319 Method for obtaining bone marrow free of tumor cells using transforming growth factor .beta.3 28 1990
5,635,489 Methods of prevention of oral mucositis with transforming growth factor .beta. 15 1995
 
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4,605,644 Method for stimulating recovery from ischemia employing ribose and adenine 51 1985
5,030,637 Anisodamine to prevent and treat eye disease 9 1990
 
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5,216,115 Polyarylate containing derivatives of the natural amino acid L-tyrosine 64 1992
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SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (2)
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6,492,106 Mammalian proteins that bind to FKBP12 in a rapamycin-dependent fashion 5 1994
 
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THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (2)
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5,580,898 Method of stabilizing microtubules 14 1994
 
The United States of America as represented by the Secretary of Agriculture (2)
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5,019,504 Production of taxol or taxol-like compounds in cell culture 79 1989
 
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4,900,561 Copper complexes of alpha-amino acids that contain terminal amino groups, and their use as nutritional supplements 25 1989
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5,424,331 Pharmaceutical compositions and dietary soybean food products for the prevention of osteoporosis 78 1994
 
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BIO-SEAL, LLC (1)
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Boehringer Mannheim Pharmaceuticals Corporation - SmithKline Beecham Corp., Ltd. Partnership No. 1 (1)
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BRITISH TECHNOLOGY GROUP LIMITED (1)
4,839,155 Iodotamoxifen derivatives and use for estrogen receptor-positive breast cancer detection and therapy 44 1987
 
BROOKWOOD PHARMACEUTICALS, INC. (1)
5,407,609 Microencapsulation process and products therefrom 220 1993
 
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4,767,758 Pharmaceutical compositions containing thiophene compounds, and new thiophene compounds 13 1987
 
COR THERAPEUTICS, INC. (1)
5,268,358 PDGF receptor blocking peptides 56 1991
 
CORNELL UNIVERSITY (1)
4,629,694 Detecting and distinguishing between plasminogen activators 17 1983
 
Cytogen Corporation (1)
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DAIICHI PHARMACEUTICAL CO., LTD. (1)
5,480,888 Inhibitor for restenosis after percutaneous coronary arterioplasty 21 1994
 
DRAXIMAGE, INC. (1)
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EXPANDABLE GRAFTS PARTNERSHIP, 8000 I.H. 10 WEST, STE. 1265, SAN ANTONIO, TX A GENERAL PARTNERSHIP OF TX. (1)
4,733,665 Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft 2282 1985
 
EXPANDABLE GRAFTS PARTNERSHIP, A TX. GENERAL PARTNERSHIP (1)
4,776,337 Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft 1193 1986
 
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5,416,205 New esters of alginic acid 14 1993
 
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Gared Corporation (1)
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GLAXO WELLCOME INC. (1)
5,681,835 Non-steroidal ligands for the estrogen receptor 28 1994
 
Godecke Aktiengesellschaft (1)
5,043,335 Indolocarbazoles and the use thereof 67 1990
 
HANSON, STEPHEN (1)
4,687,482 Vascular prosthesis 55 1984
 
Health Maintenance Programs, Inc. (1)
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HERITAGE TECHNOLOGIES, LLC (1)
5,451,414 Micronutrient supplement 10 1994
 
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4,973,755 Stable solvent adducts of Z-1-(p-.beta.-dimethylaminoethoxy-phenyl)-1-(p-hydroxyphenyl)-2-phenyl-but-1-ene 31 1988
 
HOWARD FOUNDATION, THE (1)
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IMPERIAL CHEMICAL INDUSTRIES PLC (1)
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INFIGEN, INC. (1)
4,994,384 Multiplying bovine embryos 59 1987
 
INNOVENT, INC. (1)
5,420,243 Biologically active TGF-.beta.2 peptides 23 1993
 
INTERMEDICAT GMBH, GERLISWILSTRASSE 74, CH-6020 EMMENBRUCKE, SWITZERLAND, (1)
4,784,659 Vessel and prosthesis impregnated with diisocyanate crosslinked gelatin 95 1987
 
ISOSTENT, INC. (1)
5,722,984 Antithrombogenic radioactive coating for an intravascular stent 176 1996
 
JOHNSON MATTHEY, INC. (1)
5,100,885 Copper radiosensitizers 19 1989
 
KASINKAS, MICHAEL (1)
5,053,033 Inhibition of restenosis by ultraviolet radiation 202 1990
 
KISSEI PHARMACEUTICAL CO., LTD. (1)
5,385,935 Method for the inhibition of restenosis associated with coronary intervention 39 1993
 
KOREA ATOMIC ENERGY RESEARCH INSTITUTE (1)
6,152,869 Radioactive stent and process for preparation thereof 34 1998
 
LATHAM, DANIEL W. (1)
5,464,650 Intravascular stent and method 801 1993
 
LIFESHIELD SCIENCES LLC (1)
5,053,048 Thromboresistant coating 219 1990
 
LION CORPORATION (1)
5,211,940 Transparent liquid oral composition 17 1992
 
LUDWIG INSTITUTE FOR CANCER RESEARCH A CORP. OF NEW YORK (1)
5,229,495 Substantially pure receptor like TGF-.beta. 1 binding molecules and uses thereof 48 1991
 
MARYLAND BIOPOLYMER TECHNOLOGIES, LLC (1)
5,512,055 Anti-infective and anti-inflammatory releasing systems for medical devices 204 1994
 
MATRIX PHARMACEUTICAL, INC. (1)
5,597,578 TGF-.beta. protein compositions for inhibition of cell proliferation 37 1994
 
MedInnovations, Inc. (1)
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5,441,734 Metal-interferon-alpha crystals 42 1993
 
MERRELL DOW PHARMACEUTICALS INC. (1)
5,460,807 Antiproliferative oligomers 26 1993
 
MILLENNIUM PHARMACEUTICALS, INC. (1)
5,948,639 TGF-.beta. pathway genes 12 1997
 
Mitsubishi Petrochemical Co., Ltd. (1)
4,705,647 Copper-type conductive coating composition 23 1986
 
Mobil Oil Corporation (1)
4,401,554 Split stream reforming 32 1982
 
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5,496,557 Article for the controlled delivery of an active substance, comprising a hollow space fully enclosed by a wall and filled in full or in part with one or more active substances 42 1993
 
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5,441,947 Methods of inhibiting vascular restenosis 57 1993
 
NIPPON KAYAKU KABUSHIKI KAISHA (1)
5,296,492 Certain chroman derivatives useful for treating symptoms caused by contraction of smooth muscles, circulatory diseases or epilepsy 28 1992
 
NITROMED, INC. (1)
6,087,479 Localized use of nitric oxide-adducts to prevent internal tissue damage 90 1995
 
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* 6,074,659 Therapeutic inhibitor of vascular smooth muscle cells 222 1998
 
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5,093,330 Staurosporine derivatives substituted at methylamino nitrogen 58 1991
 
NOVO PHARMACEUTICAL CORPORATION (1)
5,189,046 Protein kinase C modulators 45 1991
 
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5,318,779 Drug-impregnated ceramic 28 1990
 
ONCOGEN, A WA CORP. (1)
5,120,535 Oncostatin M and novel compositions having anti-neoplastic activity 44 1987
 
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5,324,739 Compound exhibiting antiproliferative activity against cells 20 1993
 
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5,491,173 Tri-phenyl alkene derivatives and their preparation and use 43 1994
 
PEPSICO, INC. (1)
4,835,002 Microemulsions of oil in water and alcohol 102 1987
 
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5,576,345 Method and means for inhibiting posterior capsule opacification 23 1996
 
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6,210,393 Methods and systems for the inhibition of vascular hyperplasia 77 1998
 
PHARMETRIX, MENLO PARK (1)
* 4,919,939 Periodontal disease treatment system 176 1988
 
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4,826,672 Astatinated organic compounds 36 1985
 
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6,168,619 Intravascular stent having a coaxial polymer member and end sleeves 127 1998
 
Research Triangle Institute Duke University (1)
5,436,243 Aminoanthraquinone derivatives to combat multidrug resistance 40 1993
 
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5,519,042 Method of treating hyperproliferative vascular disease 38 1994
 
SCHERING CORPORATION (1)
5,238,950 Inhibitors of platelet-derived growth factor 53 1991
 
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6,042,875 Drug-releasing coatings for medical devices 370 1999
 
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4,954,126 Prosthesis comprising an expansible or contractile tubular body 731 1989
 
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5,354,562 Process for preparing micronized polypeptide drugs 111 1993
 
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6,491,617 Medical devices that resist restenosis 28 1999
 
Sterling Drug Inc. (1)
5,145,684 Surface modified drug nanoparticles 535 1991
 
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RE33403 Method for treating disorders of the vascular and pulmonary systems 21 1989
 
SUDZUCKER AKTIENGESELLSCHAFT MANNHEIM/OCHSENFURT (1)
6,093,221 Process for reducing sulfur and vat dyes 3 1999
 
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5,478,860 Stable microemulsions for hydrophobic compound delivery 54 1993
 
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5,538,892 Nucleic acids encoding a TGF-.beta. type 1 receptor 41 1993
 
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5,401,730 Method for reducing platelet aggregation 35 1993
 
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5,126,348 Bioavailability enhancers 26 1989
 
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4,929,602 Method of inhibiting platelet dependent arterial thrombosis 53 1988
 
The Whittier Institute for Diabetes and Endocrinology (1)
5,308,622 Treatment of vascular injury 60 1992
 
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6,133,242 Inhibition of extracellular matrix synthesis by antisense compounds directed to nuclear proto-oncogenes 20 1995
 
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4,859,585 In-vitro methods for identifying compositions which are agonists and antagonists of estrogens 56 1986
 
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4,872,867 Compositions having antithrombogenic properties and blood contact medical devices using the same 123 1989
 
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5,189,212 Triarylethylene carboxylic acids with estrogenic activity 84 1990
 
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (1)
5,378,475 Sustained release drug delivery devices 183 1991
 
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (1)
5,824,647 Chemotactic wound healing peptides 17 1995
 
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5,439,689 Diltiazem formulation 36 1993
 
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WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (1)
6,544,790 Reverse transfection method 55 2000
 
WISTAR INSTITUTE OF ANATOMY AND BIOLOGY, THE, 36TH AND SPRUCE STREETS, PHILADELPHIA, PA 19104 A CORP OF PA (1)
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YOSHIDA, ROBERT (1)
5,492,895 Inhibitors of thrombosis 49 1994
 
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Other [Check patent profile for assignment information] (29)
4,487,780 Method of treatment of rheumatoid arthritis 23 1982
4,613,665 Process for covalent coupling for the production of conjugates, and polysaccharide containing products thereby obtained 127 1983
4,678,466 Internal medication delivery method and vehicle 33 1985
4,840,939 Treatment of cancer with phlorizin and its derivatives 29 1987
4,824,436 Method for the prevention of restenosis 248 1987
4,853,377 Method and composition for increasing production of serotonin 17 1988
5,002,531 Dilation catheter with an inflatable balloon 180 1988
4,968,350 Process for preparing a powder of water-insoluble polymer which can be redispersed in a liquid phase, the resulting powder and utilization thereof 42 1988
5,199,939 Radioactive catheter 270 1990
5,040,548 Angioplasty mehtod 417 1990
5,061,273 Angioplasty apparatus facilitating rapid exchanges 496 1990
5,163,952 Expandable polymeric stent with memory and delivery apparatus and method 598 1990
5,180,366 Apparatus and method for angioplasty and for preventing re-stenosis 186 1990
5,232,444 Dilatation catheter 286 1991
5,216,021 Analgesic method 11 1991
5,258,020 Method of using expandable polymeric stent with memory 301 1992
5,288,735 Treatment of glaucoma 26 1992
5,342,348 Method and device for treating and enlarging body lumens 481 1992
5,290,271 Surgical implant and method for controlled release of chemotherapeutic agents 221 1993
5,451,233 Angioplasty apparatus facilitating rapid exchanges 278 1994
5,470,876 Topical sod for treating hair loss 26 1994
5,470,883 Method of treating peripheral vasoconstriction with tamoxifen citrate 30 1994
5,693,607 Uses of TGF-.beta. receptor fragment as a therapeutic agent 25 1994
5,541,174 Analgesic method 13 1995
5,521,171 Anti-inflammatory and anti-ulcer compounds and process 11 1995
5,639,274 Integrated catheter system for balloon angioplasty and stent delivery 166 1995
5,749,888 Method of using angioplasty apparatus facilitating rapid exchanges 70 1995
6,575,993 Angioplasty apparatus facilitating rapid exchanges 86 1995
6,036,715 Angioplasty apparatus facilitating rapid exchanges 112 1997
* Cited By Examiner

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