US Patent No: 8,067,022 - Analytics, PDF, Full Text and PAIR Access

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Therapeutic inhibitor of vascular smooth muscle cells

ALSO PUBLISHED AS: 20020013275

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Abstract

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Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOSTON SCIENTIFIC SCIMED, INC.MAPLE GROVE, MN4840

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anderson, Peter G Pittsford, NY 20 892
Kunz, Lawrence L - 37 2007

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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Other [Check patent profile for assignment information] (31)
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5,002,531 Dilation catheter with an inflatable balloon 177 1988
4,968,350 Process for preparing a powder of water-insoluble polymer which can be redispersed in a liquid phase, the resulting powder and utilization thereof 42 1988
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5,040,548 Angioplasty mehtod 400 1990
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5,180,366 Apparatus and method for angioplasty and for preventing re-stenosis 184 1990
5,232,444 Dilatation catheter 266 1991
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5,258,020 Method of using expandable polymeric stent with memory 290 1992
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5,290,271 Surgical implant and method for controlled release of chemotherapeutic agents 213 1993
5,451,233 Angioplasty apparatus facilitating rapid exchanges 261 1994
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5,521,171 Anti-inflammatory and anti-ulcer compounds and process 11 1995
5,639,274 Integrated catheter system for balloon angioplasty and stent delivery 151 1995
5,749,888 Method of using angioplasty apparatus facilitating rapid exchanges 70 1995
6,575,993 Angioplasty apparatus facilitating rapid exchanges 79 1995
6,036,715 Angioplasty apparatus facilitating rapid exchanges 109 1997

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