Therapeutic inhibitor of vascular smooth muscle cells
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Nov 29, 2011
Grant Date -
Jan 31, 2002
app pub date -
Jul 20, 2001
filing date -
Sep 25, 1992
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.

First Claim
Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | Total Patents |
---|---|---|
BOSTON SCIENTIFIC SCIMED, INC. | MAPLE GROVE, MN | 5612 |
International Classification(s)

- [Classification Symbol]
- [Patents Count]
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Anderson, Peter G | Birmingham, US | 15 | 1151 |
Kunz, Lawrence L | Sammamish, US | 31 | 2758 |
Cited Art Landscape
Patent Info | (Count) | # Cites | Year |
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|
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4487780 Method of treatment of rheumatoid arthritis | 23 | 1982 | |
4613665 Process for covalent coupling for the production of conjugates, and polysaccharide containing products thereby obtained | 156 | 1983 | |
4678466 Internal medication delivery method and vehicle | 41 | 1985 | |
4840939 Treatment of cancer with phlorizin and its derivatives | 31 | 1987 | |
4824436 Method for the prevention of restenosis | 277 | 1987 | |
4853377 Method and composition for increasing production of serotonin | 17 | 1988 | |
5002531 Dilation catheter with an inflatable balloon | 200 | 1988 | |
4968350 Process for preparing a powder of water-insoluble polymer which can be redispersed in a liquid phase, the resulting powder and utilization thereof | 42 | 1988 | |
5199939 Radioactive catheter | 286 | 1990 | |
5040548 Angioplasty mehtod | 525 | 1990 | |
5061273 Angioplasty apparatus facilitating rapid exchanges | 592 | 1990 | |
5163952 Expandable polymeric stent with memory and delivery apparatus and method | 727 | 1990 | |
5180366 Apparatus and method for angioplasty and for preventing re-stenosis | 198 | 1990 | |
5232444 Dilatation catheter | 350 | 1991 | |
5216021 Analgesic method | 11 | 1991 | |
5258020 Method of using expandable polymeric stent with memory | 342 | 1992 | |
5288735 Treatment of glaucoma | 26 | 1992 | |
5342348 Method and device for treating and enlarging body lumens | 531 | 1992 | |
5451233 Angioplasty apparatus facilitating rapid exchanges | 366 | 1994 | |
5470876 Topical sod for treating hair loss | 29 | 1994 | |
5470883 Method of treating peripheral vasoconstriction with tamoxifen citrate | 33 | 1994 | |
5693607 Uses of TGF-.beta. receptor fragment as a therapeutic agent | 30 | 1994 | |
5541174 Analgesic method | 13 | 1995 | |
5521171 Anti-inflammatory and anti-ulcer compounds and process | 11 | 1995 | |
5639274 Integrated catheter system for balloon angioplasty and stent delivery | 288 | 1995 | |
5749888 Method of using angioplasty apparatus facilitating rapid exchanges | 82 | 1995 | |
6575993 Angioplasty apparatus facilitating rapid exchanges | 123 | 1995 | |
6036715 Angioplasty apparatus facilitating rapid exchanges | 137 | 1997 | |
|
|||
5189212 Triarylethylene carboxylic acids with estrogenic activity | 89 | 1990 | |
|
|||
4670428 Method for treating convulsions and epilepsy with organic copper compounds | 12 | 1984 | |
4657928 Organic copper complexes as radioprotectants | 15 | 1984 | |
4952607 Copper complex for treating cancer | 17 | 1986 | |
|
|||
6476200 Mammalian proteins that bind to FKBP12 in a rapamycin-dependent fashion | 5 | 1994 | |
6492106 Mammalian proteins that bind to FKBP12 in a rapamycin-dependent fashion | 6 | 1994 | |
|
|||
4705647 Copper-type conductive coating composition | 23 | 1986 | |
|
|||
4389330 Microencapsulation process | 339 | 1980 | |
4732763 Active/passive immunization of the internal female reproductive organs | 73 | 1984 | |
|
|||
6210393 Methods and systems for the inhibition of vascular hyperplasia | 121 | 1998 | |
|
|||
5681835 Non-steroidal ligands for the estrogen receptor | 33 | 1994 | |
|
|||
4664097 Nuclear transplantation in the mammalian embryo by microsurgery and cell fusion | 17 | 1984 | |
|
|||
4835002 Microemulsions of oil in water and alcohol | 112 | 1987 | |
|
|||
5234957 Compositions and methods for topical administration of pharmaceutically active agents | 167 | 1991 | |
5332576 Compositions and methods for topical administration of pharmaceutically active agents | 125 | 1993 | |
5446070 Compositions and methods for topical administration of pharmaceutically active agents | 257 | 1993 | |
|
|||
5248764 Chelate derivatives of atrial natriuretic factor (ANF) | 51 | 1992 | |
|
|||
5847007 Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells | 22 | 1994 | |
5472985 Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells | 43 | 1994 | |
5545569 Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells | 60 | 1995 | |
5595722 Method for identifying an agent which increases TGF-beta levels | 86 | 1995 | |
5770609 Prevention and treatment of cardiovascular pathologies | 108 | 1995 | |
5599844 Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells | 49 | 1995 | |
5773479 Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells | 33 | 1995 | |
5945456 Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells | 36 | 1997 | |
6251920 Prevention and treatment of cardiovascular pathologies | 17 | 1998 | |
|
|||
5053033 Inhibition of restenosis by ultraviolet radiation | 306 | 1990 | |
|
|||
5059166 Intra-arterial stent with the capability to inhibit intimal hyperplasia | 473 | 1989 | |
5176617 Use of a stent with the capability to inhibit malignant growth in a vessel such as a biliary duct | 249 | 1991 | |
|
|||
4973755 Stable solvent adducts of Z-1-(p-.beta.-dimethylaminoethoxy-phenyl)-1-(p-hydroxyphenyl)-2-phenyl-but-1-ene | 31 | 1988 | |
|
|||
4996194 Pressure treated autoimmune specific T cell compositions | 14 | 1986 | |
|
|||
5516807 Method for treating vascular proliferative disorders following balloon angioplasty | 35 | 1994 | |
|
|||
4839155 Iodotamoxifen derivatives and use for estrogen receptor-positive breast cancer detection and therapy | 47 | 1987 | |
|
|||
5268358 PDGF receptor blocking peptides | 62 | 1991 | |
|
|||
4872867 Compositions having antithrombogenic properties and blood contact medical devices using the same | 132 | 1989 | |
|
|||
4655771 Prosthesis comprising an expansible or contractile tubular body | 1762 | 1983 | |
5061275 Self-expanding prosthesis | 788 | 1989 | |
|
|||
6309414 Angioplasty stents | 183 | 1997 | |
6616690 Angioplasty stents | 53 | 2001 | |
|
|||
5292802 Collagen-polymer tubes for use in vascular surgery | 182 | 1992 | |
5308889 Dehydrated collagen-polymer strings | 170 | 1992 | |
|
|||
5474563 Cardiovascular stent and retrieval apparatus | 262 | 1994 | |
|
|||
5411988 Compositions and methods for inhibiting inflammation and adhesion formation | 81 | 1993 | |
|
|||
6544790 Reverse transfection method | 64 | 2000 | |
|
|||
4867973 Antibody-therapeutic agent conjugates | 211 | 1984 | |
|
|||
5356713 Magnetizable composite microspheres of hydrophobic crosslinked polymer, process for preparing them and their application in biology | 65 | 1993 | |
|
|||
5512055 Anti-infective and anti-inflammatory releasing systems for medical devices | 281 | 1994 | |
|
|||
5460807 Antiproliferative oligomers | 26 | 1993 | |
|
|||
4744981 Trichothecene antibody conjugates | 43 | 1985 | |
4879225 Enhanced production of antibodies utilizing insolubilized immune complexes | 27 | 1987 | |
4897255 Metal radionuclide labeled proteins for diagnosis and therapy | 125 | 1987 | |
|
|||
4401554 Split stream reforming | 39 | 1982 | |
|
|||
5650447 Nitric oxide-releasing polymers to treat restenosis and related disorders | 86 | 1994 | |
|
|||
5284869 Photophoresis methods for treating atherosclerosis and for preventing restenosis following angioplasty | 30 | 1991 | |
|
|||
6133242 Inhibition of extracellular matrix synthesis by antisense compounds directed to nuclear proto-oncogenes | 33 | 1995 | |
|
|||
4997652 Biodegradable ocular implants | 286 | 1989 | |
|
|||
5378475 Sustained release drug delivery devices | 270 | 1991 | |
|
|||
6093221 Process for reducing sulfur and vat dyes | 3 | 1999 | |
|
|||
5140012 Method for preventing onset of restenosis after angioplasty employing pravastatin | 52 | 1990 | |
5166143 Method for preventing onset of restenosis after angioplasty employing an ace inhibitor | 35 | 1991 | |
|
|||
5324739 Compound exhibiting antiproliferative activity against cells | 21 | 1993 | |
|
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5362478 Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell | 166 | 1993 | |
|
|||
5199951 Method of drug application in a transporting medium to an arterial wall injured during angioplasty | 151 | 1991 | |
|
|||
6198016 Wet skin adhesive article | 44 | 1999 | |
|
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4605644 Method for stimulating recovery from ischemia employing ribose and adenine | 66 | 1985 | |
5030637 Anisodamine to prevent and treat eye disease | 9 | 1990 | |
|
|||
5211940 Transparent liquid oral composition | 18 | 1992 | |
|
|||
5462966 Methods for the prevention and control of cellular damage resulting from coronary artery occlusion-reperfusion | 8 | 1993 | |
|
|||
5480888 Inhibitor for restenosis after percutaneous coronary arterioplasty | 21 | 1994 | |
|
|||
5112305 Catheter device for intramural delivery of therapeutic agents | 185 | 1990 | |
5242397 Catheter device and method of use for intramural delivery of protein kinase C and tyrosine protein kinase inhibitors to prevent restenosis after balloon angioplasty | 90 | 1992 | |
5562922 Drug incorporating and release polymeric coating for bioprosthesis | 171 | 1995 | |
5900246 Drug incorporating and releasing polymeric coating for bioprosthesis | 98 | 1995 | |
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* 5413797 Controlled release ACTH containing microspheres | 57 | 1994 | |
|
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5282785 Drug delivery apparatus and method | 317 | 1992 | |
5458568 Porous balloon for selective dilatation and drug delivery | 307 | 1993 | |
|
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4555402 Physiologically active substance K-252, process for producing same and pharmaceutical composition containing same | 26 | 1984 | |
4935415 UCN-01 and process for production thereof | 24 | 1987 | |
5344926 Process for producing staurosporine derivatives | 33 | 1993 | |
|
|||
4320896 Shock-absorbing assembly for basketball backboard | 40 | 1980 | |
|
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5731144 High affinity TGF.beta. nucleic acid ligands | 21 | 1995 | |
5731424 High affinity TGF.beta. nucleic acid ligands and inhibitors | 42 | 1995 | |
|
|||
5700559 Durable hydrophilic surface coatings | 154 | 1994 | |
|
|||
5114847 Process for the production of permanently culturable animal and human cell lines and the use thereof | 11 | 1990 | |
|
|||
4916193 Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides | 217 | 1988 | |
4990158 Synthetic semiabsorbable tubular prosthesis | 67 | 1989 | |
5185408 Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides | 111 | 1991 | |
|
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5393772 Use of, and method of treatment using, hydroxycarbazole compounds for inhibition of smooth muscle migration and proliferation | 61 | 1993 | |
5453436 Treatment of athereosclerosis using, carbazolyl-(4)-oxypropanolamine compounds | 49 | 1994 | |
|
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4793348 Balloon expandable vena cava filter to prevent migration of lower extremity venous clots into the pulmonary circulation | 495 | 1986 | |
|
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5032679 Heparin fragments as inhibitors of smooth muscle cell proliferation | 62 | 1989 | |
5280016 Non-anticoagulant heparin derivatives | 54 | 1991 | |
5380716 Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation | 56 | 1992 | |
|
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5093330 Staurosporine derivatives substituted at methylamino nitrogen | 62 | 1991 | |
|
|||
4442119 Cyclopropyl analogs as estrogenic and anti-fertility agents | 36 | 1982 | |
4879315 Cyclopropyl analogs as anti-estrogenic, anti-tumor and female fertility agents | 44 | 1987 | |
5015666 Triarylcyclopropanes as antiestrogens and antitumor agents | 36 | 1989 | |
5098903 Diphenylcyclopropyl analogs as antiestrogenic and antitumor agents | 51 | 1989 | |
5324736 Diphenylcyclopropyl analogs as antiestrogenic and antitumor agents | 31 | 1993 | |
5658927 Diphenylcyclopropyl analogs | 12 | 1995 | |
5658951 Diphenylcyclopropyl analogs | 11 | 1995 | |
|
|||
5314679 Vascular magnetic resonance imaging agent comprising nanoparticles | 54 | 1992 | |
|
|||
5464650 Intravascular stent and method | 945 | 1993 | |
|
|||
5453492 60 kDa transforming growth factor-.beta.-binding protein and its use to detect or purify TGF-.beta. | 64 | 1993 | |
5705609 Decorin fragments inhibiting cell regulatory factors | 24 | 1995 | |
|
|||
5290271 Surgical implant and method for controlled release of chemotherapeutic agents | 452 | 1993 | |
|
|||
5354801 Process for producing small polymer phase droplet microemulsions by multistep aqueous phase addition | 33 | 1993 | |
|
|||
4317915 Novel thiophene derivatives | 17 | 1980 | |
4428963 Novel thiophene derivatives | 14 | 1983 | |
|
|||
6241762 Expandable medical device with ductile hinges | 294 | 1998 | |
6562065 Expandable medical device with beneficial agent delivery mechanism | 122 | 2000 | |
6764507 Expandable medical device with improved spatial distribution | 92 | 2001 | |
|
|||
4687482 Vascular prosthesis | 66 | 1984 | |
|
|||
4990538 Use of toremifene and its metabolites for the reversal of multidrug resistance of cancer cells against cytotoxic drugs | 57 | 1989 | |
5354774 Inhibition of smooth muscle cell proliferation by 8-methoxypsoralen photoactivated by visible light | 44 | 1992 | |
|
|||
5015578 BMY-41950 antitumor antibiotic | 28 | 1990 | |
5073633 BMY-41950 antitumor antibiotic | 29 | 1990 | |
5304541 Methods using novel chimeric transforming growth factor-.beta.1/.beta.2 | 37 | 1991 | |
5444164 TGF-.beta. induced gene | 36 | 1992 | |
|
|||
4629694 Detecting and distinguishing between plasminogen activators | 22 | 1983 | |
|
|||
5213580 Biodegradable polymeric endoluminal sealing process | 303 | 1992 | |
5328471 Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens | 594 | 1993 | |
5662712 Apparatus for intraluminal photothermoforming | 136 | 1995 | |
5749915 Polymeric endoluminal paving process | 97 | 1995 | |
|
|||
4389393 Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose | 349 | 1982 | |
|
|||
5008279 Circulation-active fluoromethoxyphenyl dihydropyridine compounds | 13 | 1988 | |
|
|||
4776337 Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft | 1367 | 1986 | |
|
|||
4733665 Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft | 2786 | 1985 | |
|
|||
5075321 Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes | 101 | 1988 | |
5580898 Method of stabilizing microtubules | 14 | 1994 | |
|
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5240913 Inhibitors of thrombin | 32 | 1991 | |
|
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5512268 Polymeric shells for medical imaging prepared from synthetic polymers, and methods for the use thereof | 120 | 1995 | |
|
|||
6001622 Integrin-linked kinase and its use | 24 | 1998 | |
|
|||
5221620 Cloning and expression of transforming growth factor .beta.2 | 41 | 1989 | |
5340925 Normal human growth regulatory receptor for TGF-.beta. | 32 | 1992 | |
|
|||
5037641 Beauty preparations having anti-fading effect and a process for preparing the same | 9 | 1988 | |
|
|||
4757059 Method for treating convulsions and epilepsy with organic copper compounds | 17 | 1986 | |
4758554 Method for treating convulsions and epilepsy with organic copper compounds | 11 | 1986 | |
4758555 Method for treating convulsions and epilepsy with organic copper compounds | 9 | 1986 | |
|
|||
6152869 Radioactive stent and process for preparation thereof | 37 | 1998 | |
|
|||
6110483 Adherent, flexible hydrogel and medicated coatings | 378 | 1997 | |
|
|||
5280109 Isolated, large latent complexes of TGF-.beta.2 and TGF-.beta.3, and new binding protein for latent form TGF-.beta.1, TGF-.beta.2 and TGF-.beta.3 LTBP-2 | 33 | 1992 | |
5346993 Isolated, large latent complexes of TGF-.beta.2 and TGF-.beta.3, and new binding protein for latent form TGF-.beta.1, TGF-.beta.2 and TGF-.beta.3 LTBP-2 | 30 | 1993 | |
5578703 Substantially pure receptor like TFG-.beta.1 binding molecules | 14 | 1994 | |
5731200 Isolated nucleic acid encoding receptor-like TGF-.beta.1 binding protein | 13 | 1995 | |
|
|||
4786500 Programmable agent delivery system | 43 | 1986 | |
|
|||
5238950 Inhibitors of platelet-derived growth factor | 75 | 1991 | |
|
|||
5667764 Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles | 89 | 1992 | |
|
|||
5180376 Non-buckling thin-walled sheath for the percutaneous insertion of intraluminal catheters | 170 | 1990 | |
|
|||
4929602 Method of inhibiting platelet dependent arterial thrombosis | 53 | 1988 | |
|
|||
4310523 Combined antiestrogens and antigonadotropically effective antiandrogens for the prophylaxis and therapy of hyperplasia of the prostate | 27 | 1980 | |
5316766 Thrombosis treatment with fibrinolytics and prostacyclins | 30 | 1990 | |
|
|||
4886062 Intravascular radially expandable stent and method of implant | 1510 | 1987 | |
5102402 Releasable coatings on balloon catheters | 460 | 1991 | |
5282823 Intravascular radially expandable stent | 536 | 1992 | |
5607463 Intravascular medical device | 387 | 1993 | |
5545208 Intralumenal drug eluting prosthesis | 392 | 1993 | |
5429618 Thromboresistant articles | 71 | 1994 | |
5510077 Method of making an intraluminal stent | 147 | 1994 | |
5571166 Method of making an intraluminal stent | 203 | 1994 | |
5591224 Bioelastomeric stent | 293 | 1994 | |
5599352 Method of making a drug eluting stent | 216 | 1994 | |
5554182 Method for preventing restenosis | 202 | 1995 | |
5591227 Drug eluting stent | 325 | 1995 | |
5697967 Drug eluting stent | 342 | 1995 | |
5800507 Intraluminal stent | 136 | 1995 | |
5837008 Intravascular stent and method | 392 | 1995 | |
5849034 Intraluminal stent | 83 | 1995 | |
5624411 Intravascular stent and method | 599 | 1995 | |
5679400 Intravascular stent and method | 603 | 1995 | |
5776184 Intravasoular stent and method | 436 | 1996 | |
5824048 Method for delivering a therapeutic substance to a body lumen | 538 | 1996 | |
5779732 Method and apparatus for implanting a film with an exandable stent | 67 | 1997 | |
6106454 Medical device for delivering localized radiation | 92 | 1997 | |
6203536 Medical device for delivering a therapeutic substance and method therefor | 75 | 1997 | |
6099499 Device for in vivo radiation delivery and method for delivery | 35 | 1998 | |
6013099 Medical device for delivering a water-insoluble therapeutic salt or substance | 114 | 1998 | |
6187370 Medical device for delivering a therapeutic substance and method therefor | 52 | 1999 | |
|
|||
5280040 Methods for reducing bone loss using centchroman derivatives | 69 | 1993 | |
5451603 3,4-diarylchromans for treatment of dermatitis | 13 | 1993 | |
5480903 3,4-diarylchromans for inhibiting calmodulin activity | 14 | 1994 | |
|
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4485096 Tissue-equivalent and method for preparation thereof | 210 | 1982 | |
4485097 Bone-equivalent and method for preparation thereof | 240 | 1983 | |
5114719 Extended drug delivery of small, water-soluble molecules | 72 | 1989 | |
5175235 Branched polyanhydrides | 58 | 1990 | |
5545409 Delivery system for controlled release of bioactive factors | 45 | 1994 | |
5567417 Method for inhibiting angiogenesis using heparinase | 47 | 1995 | |
5797898 Microchip drug delivery devices | 446 | 1996 | |
|
|||
5436243 Aminoanthraquinone derivatives to combat multidrug resistance | 45 | 1993 | |
|
|||
4656083 Plasma gas discharge treatment for improving the biocompatibility of biomaterials | 210 | 1985 | |
5034265 Plasma gas discharge treatment for improving the compatibility of biomaterials | 67 | 1989 | |
|
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* 5171217 Method for delivery of smooth muscle cell inhibitors | 317 | 1991 | |
5116864 Method for preventing restenosis following reconfiguration of body vessels | 139 | 1991 | |
|
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5688855 Thin film hydrophilic coatings | 74 | 1995 | |
|
|||
4536516 Alkene derivatives | 53 | 1984 | |
|
|||
RE33403 Method for treating disorders of the vascular and pulmonary systems | 21 | 1989 | |
|
|||
6555138 Polyethylene glycol matrix pellets for greasy, oily or sticky drug substances | 10 | 1999 | |
|
|||
5478860 Stable microemulsions for hydrophobic compound delivery | 62 | 1993 | |
|
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5538892 Nucleic acids encoding a TGF-.beta. type 1 receptor | 42 | 1993 | |
|
|||
6491617 Medical devices that resist restenosis | 33 | 1999 | |
|
|||
4391797 Systems for the controlled release of macromolecules | 125 | 1981 | |
4753652 Biomaterial implants which resist calcification | 301 | 1986 | |
5994388 Cytochalasin and isoindolinone derivatives as inhibitors of angiogenesis | 5 | 1998 | |
|
|||
4859585 In-vitro methods for identifying compositions which are agonists and antagonists of estrogens | 59 | 1986 | |
|
|||
5468746 Compounds active on the cardiovascular system | 33 | 1991 | |
|
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4440754 Anti-inflammatory and anti-ulcer compounds and process | 27 | 1980 | |
4999347 Analgesic method | 27 | 1989 | |
5082834 Anti-inflammatory and anti-ulcer compounds and process | 10 | 1990 | |
|
|||
5441947 Methods of inhibiting vascular restenosis | 57 | 1993 | |
|
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5492895 Inhibitors of thrombosis | 49 | 1994 | |
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5722984 Antithrombogenic radioactive coating for an intravascular stent | 230 | 1996 | |
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5660873 Coating intraluminal stents | 49 | 1994 | |
|
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5543155 Diffusion-osmotic controlled drug-release pharmaceutical composition and process for preparing same | 34 | 1994 | |
|
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5145684 Surface modified drug nanoparticles | 743 | 1991 | |
|
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5364632 Medicinal emulsions | 123 | 1993 | |
|
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4826672 Astatinated organic compounds | 37 | 1985 | |
|
|||
4675189 Microencapsulation of water soluble active polypeptides | 352 | 1985 | |
4962091 Controlled release of macromolecular polypeptides | 224 | 1986 | |
|
|||
5447724 Medical device polymer | 488 | 1993 | |
5569463 Medical device polymer | 385 | 1995 | |
|
|||
5429634 Biogenic implant for drug delivery and method | 186 | 1993 | |
5419760 Medicament dispensing stent for prevention of restenosis of a blood vessel | 270 | 1994 | |
|
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4984594 Vacuum method for removing soil contamination utilizing surface electrical heating | 359 | 1989 | |
5219548 High affinity halogenated-tamoxifen derivatives and uses thereof | 41 | 1990 | |
5238714 Efficient microcapsule preparation and method of use | 73 | 1990 | |
5192525 High affinity tamoxifen derivatives and uses thereof | 65 | 1991 | |
5656450 Activation of latent transforming growth factor .beta. by matrix vesicles | 28 | 1994 | |
|
|||
* 4942184 Water soluble, antineoplastic derivatives of taxol | 165 | 1988 | |
5405919 Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders | 144 | 1992 | |
5656587 Promotion of cell proliferation by use of transforming growth factor beta (TGF-.beta.) | 37 | 1993 | |
5525357 Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same | 127 | 1993 | |
5705477 Compositions of transforming growth factor .beta.(TGF-.beta.) which promotes wound healing and methods for their use | 28 | 1994 | |
5632981 Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same | 73 | 1994 | |
5616608 Method of treating atherosclerosis or restenosis using microtubule stabilizing agent | 226 | 1996 | |
6429232 Method of treating atherosclerosis or restenosis using microtubule stabilizing agent | 57 | 1997 | |
6200558 Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same | 40 | 1997 | |
6403635 Method of treating atherosclerosis or restenosis using microtubule stabilizing agent | 66 | 2000 | |
6379660 Nitric oxide-releasing 1-[(2-carboxylato)pyrrolidin-1-yl] diazen-1-ium-1,2-diolates and composition comprising same | 40 | 2000 | |
|
|||
4282246 Antidiabetic furancarboxylic and thiphenecarboxylic acids | 13 | 1980 | |
5441986 Estrogen agonists as remedies for prostate and cardiovascular diseases | 34 | 1994 | |
|
|||
5824647 Chemotactic wound healing peptides | 19 | 1995 | |
|
|||
4323707 Antifertility compounds | 22 | 1980 | |
4380635 Synthesis of acylated benzothiophenes | 269 | 1981 | |
4418068 Antiestrogenic and antiandrugenic benzothiophenes | 395 | 1981 | |
5270047 Local delivery of dipyridamole for the treatment of proliferative diseases | 40 | 1991 | |
5482949 Sulfonate derivatives of 3-aroylbenzo[b]thiophenes | 53 | 1993 | |
5445941 Method for screening anti-osteoporosis agents | 38 | 1993 | |
5391557 Methods for the treatment of peri-menopausal syndrome | 44 | 1993 | |
5418252 Method for inhibiting cartilage degradation | 28 | 1993 | |
5441964 Methods for inhibiting bone loss using substituted benzothiophene | 37 | 1993 | |
5457113 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis | 100 | 1993 | |
5457116 Methods of inhibiting uterine fibrosis | 32 | 1993 | |
5461065 Methods for inhibiting endometriosis | 26 | 1993 | |
5482950 Methods for lowering serum cholesterol | 16 | 1993 | |
5480904 Methods for inhibiting uterine fibrosis | 17 | 1993 | |
5389670 Methods of inhibiting the symptoms of premenstrual syndrome/late luteal phase dysphoric disorder | 39 | 1993 | |
5439923 Method of inhibiting seborrhea and acne | 27 | 1993 | |
5439931 Method for increasing libido in post-menopausal women | 27 | 1993 | |
5441965 Methods of inhibiting thrombin | 32 | 1993 | |
5441966 Methods of inhibiting Turner's syndrome | 24 | 1993 | |
5446053 Methods of inhibiting dysfunctional uterine bleeding | 28 | 1993 | |
5447941 Methods of inhibiting pulmonary hypertensive diseases with raloxifene and related benzothiophenes | 30 | 1993 | |
5451589 Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism | 20 | 1993 | |
5451590 Methods of inhibiting sexual precocity | 20 | 1993 | |
5461064 Methods of inhibiting atrophy of the skin and vagina | 25 | 1993 | |
5462949 Methods of inhibiting fertility in women | 24 | 1993 | |
5462950 Methods of treating menstrual symptoms and compositions therefore | 33 | 1993 | |
5492927 Non-peptide tachykinin receptor antagonists to treat allergy | 37 | 1993 | |
5521198 Methods of inhibiting autoimmune diseases | 19 | 1993 | |
5552415 Method of inhibiting Alzheimer's Disease | 34 | 1993 | |
5574047 Methods of inhibiting imperfect tissue repair | 14 | 1993 | |
5393763 Methods for inhibiting bone loss | 96 | 1994 | |
5478847 Methods of use for inhibiting bone loss and lowering serum cholesterol | 29 | 1994 | |
5384332 Methods for inhibiting aortal smooth muscle cell proliferation and restenosis with 1,1,2-triphenylbut-1-ene derivatives | 58 | 1994 | |
5426123 Method for lowering serum cholesterol with 1,1,2-triphenylbut-1-ene derivatives | 23 | 1994 | |
5455275 Methods for inhibiting endometriosis and uterine fibroid disease with 1,1,2-triphenylbut-1-ene derivatives | 37 | 1994 | |
5466810 2-amino-3-aroyl-benzo[.beta.]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[.beta.]thiophenes | 23 | 1994 | |
5434166 Methods of inhibiting demyelinating and desmyelinating diseases | 29 | 1994 | |
5496828 Methods of inhibiting ulcerative mucositis | 25 | 1994 | |
5457117 Method for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[B][2-(piperidin-1-yl)ethoxyphenylimethanone hydrochloride | 39 | 1994 | |
5453442 Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease | 28 | 1994 | |
5567713 Hypoglycemic agents | 19 | 1995 | |
5489587 Benzofurans used to inhibit bone loss | 21 | 1995 | |
5571808 Method for treating smoking-related bone loss | 10 | 1995 | |
5484808 Methods of inhibiting cell-cell adhesion | 33 | 1995 | |
5510370 Parathyroid hormone and raloxifene for increasing bone mass | 67 | 1995 | |
5525624 Non-peptide tachykinin receptor antagonists to treat psycological disorder | 22 | 1995 | |
5686467 Methods of inhibiting imperfect tissue repair | 12 | 1995 | |
5686476 Methods of inhibiting Alzheimer's Disease | 24 | 1995 | |
5610166 Methods for inhibiting angiogenesis | 17 | 1995 | |
5563054 Process for preparation of benzo[B]thiophene glucuronides | 14 | 1995 | |
5462937 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis | 32 | 1995 | |
5492926 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis | 22 | 1995 | |
5496851 Methods of inhibiting cell-cell adhesion | 18 | 1995 | |
5508292 Methods of inhibiting thrombin | 22 | 1995 | |
5534527 Methods for inhibiting bone loss by treating with aroylbenzothiophenes and estrogen | 30 | 1995 | |
5610168 Methods of use for inhibiting bone loss and lowering serum cholesterol | 13 | 1995 | |
5641790 Methods of use for inhibiting bone loss and lowering serum cholesterol | 25 | 1995 | |
5688813 Methods of inhibiting thrombin | 12 | 1995 | |
5484798 Benzothiopene compounds, compositions, and method of inhibiting restenosis | 35 | 1995 | |
5492921 Benzothiophene compounds, compositions, and methods for inhibiting aortal smooth muscle proliferation | 11 | 1995 | |
5484795 Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting restenosis | 40 | 1995 | |
5484796 Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting aortal smooth muscle cell proliferation | 14 | 1995 | |
5484797 Naphthly compounds, intermediates, processes, compositions, and method for inhibiting endometrosis | 18 | 1995 | |
5622975 Methods for inhibiting vascular smooth muscle cell migration | 27 | 1995 | |
5492922 Benzothiophene compounds intermediate compositions and methods for inhibiting aortal smooth muscle proliferation | 53 | 1995 | |
5521172 Methods for lowering serum cholesterol | 7 | 1995 | |
5552433 Method for lowering serum cholesterol | 8 | 1995 | |
5556876 Methods for lowering serum cholesterol | 5 | 1995 | |
5652259 Methods of inhibiting Alzheimer's disease | 11 | 1996 | |
5726186 Pentacyclic compounds, intermediates, processes, compositions, and methods | 10 | 1996 | |
5747510 Pharmaceutical unit dosage formulations | 20 | 1997 | |
|
|||
5189046 Protein kinase C modulators | 45 | 1991 | |
|
|||
5491173 Tri-phenyl alkene derivatives and their preparation and use | 50 | 1994 | |
|
|||
5416205 New esters of alginic acid | 15 | 1993 | |
|
|||
5126348 Bioavailability enhancers | 26 | 1989 | |
|
|||
5100885 Copper radiosensitizers | 19 | 1989 | |
|
|||
5026537 Methods for imaging atherosclerotic plaque | 54 | 1989 | |
|
|||
5441734 Metal-interferon-alpha crystals | 44 | 1993 | |
|
|||
5391378 Two-part medicinal tablet and method of manufacture | 34 | 1993 | |
|
|||
4739762 Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft | 1289 | 1986 | |
5102417 Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft | 1020 | 1988 | |
4994071 Bifurcating stent apparatus and method | 1068 | 1989 | |
5049132 Balloon catheter for delivering therapeutic agents | 413 | 1990 | |
5213576 Therapeutic porous balloon catheter | 345 | 1991 | |
6146358 Method and apparatus for delivery of therapeutic agent | 232 | 1992 | |
5486357 Radiofrequency plasma biocompatibility treatment of inside surfaces | 33 | 1993 | |
5356433 Biocompatible metal surfaces | 385 | 1993 | |
5863285 Balloon catheter with radioactive means | 79 | 1997 | |
2004/0236,416 Increased biocompatibility of implantable medical devices | 86 | 2004 | |
|
|||
5342926 Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport | 15 | 1993 | |
5407658 Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport | 16 | 1994 | |
5583153 Use of taxol in the treatment of rheumatoid arthritis | 41 | 1994 | |
|
|||
5326757 Pharmaceutically active antioxidant containing composition and the method of its use to prevent and treat restenosis following angioplasty | 84 | 1993 | |
|
|||
4767758 Pharmaceutical compositions containing thiophene compounds, and new thiophene compounds | 13 | 1987 | |
|
|||
5422362 Method to inhibit restenosis | 78 | 1993 | |
|
|||
5521191 Method for treatment of arterial stenosis | 21 | 1994 | |
|
|||
5318779 Drug-impregnated ceramic | 33 | 1990 | |
|
|||
4696949 Novel tri-phenyl alkane and alkene derivatives and their preparation and use | 54 | 1986 | |
4996225 Tri-phenyl alkane derivatives and their oestrogenic, anti-oestrogenic and progestanic uses | 33 | 1989 | |
5605700 Topical administration of toremifene and its metabolites | 29 | 1994 | |
|
|||
5527337 Bioabsorbable stent and method of making the same | 489 | 1994 | |
|
|||
5108989 Method of predisposing mammals to accelerated tissue repair | 68 | 1990 | |
5208019 Use of gamma-interferon for the treatment of vascular stenosis | 40 | 1991 | |
5118791 Biologically active polypeptides based on transforming growth factor-.beta. | 34 | 1991 | |
5216126 Receptor polypeptides and their production and uses | 81 | 1991 | |
5166191 Use of relaxin in cardiovascular therapy | 39 | 1991 | |
5268455 Process for making biologically active polypeptides based on transforming growth factor-.beta.sequences | 20 | 1992 | |
5284763 Nucleic acid encoding TGF-.beta. and its uses | 37 | 1992 | |
5482851 Nucleic acid encoding TGF-.beta. and its uses | 8 | 1993 | |
|
|||
5304325 Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use | 52 | 1991 | |
|
|||
5496581 Polymeric coating | 26 | 1993 | |
|
|||
5451414 Micronutrient supplement | 12 | 1994 | |
|
|||
5395842 Anti-estrogenic compounds and compositions | 115 | 1991 | |
|
|||
5824054 Coiled sheet graft stent and methods of making and use | 199 | 1997 | |
|
|||
5514154 Expandable stents | 802 | 1994 | |
6656216 Composite stent with regioselective material | 224 | 2001 | |
|
|||
5260224 Therapeutic uses of actin-binding compounds | 39 | 1991 | |
5358844 Preservation of blood platelets | 43 | 1993 | |
|
|||
5597578 TGF-.beta. protein compositions for inhibition of cell proliferation | 38 | 1994 | |
|
|||
5439689 Diltiazem formulation | 72 | 1993 | |
|
|||
5354562 Process for preparing micronized polypeptide drugs | 147 | 1993 | |
|
|||
4900561 Copper complexes of alpha-amino acids that contain terminal amino groups, and their use as nutritional supplements | 32 | 1989 | |
4956188 Copper complexes with alpha hydroxy organic acids and their use as nutritional supplements | 30 | 1989 | |
|
|||
4954126 Prosthesis comprising an expansible or contractile tubular body | 919 | 1989 | |
|
|||
5424331 Pharmaceutical compositions and dietary soybean food products for the prevention of osteoporosis | 85 | 1994 | |
|
|||
6544544 Anti-angiogenic compositions and methods of use | 196 | 2001 | |
|
|||
* 4919939 Periodontal disease treatment system | 201 | 1988 | |
|
|||
5716981 Anti-angiogenic compositions and methods of use | 846 | 1995 | |
|
|||
5195984 Expandable intraluminal graft | 730 | 1991 | |
5902332 Expandable intraluminal graft | 225 | 1992 | |
|
|||
4906452 Trichothecene conjugates and methods of use | 31 | 1988 | |
5066789 Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages | 40 | 1989 | |
|
|||
5346702 Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization | 120 | 1992 | |
|
|||
5296492 Certain chroman derivatives useful for treating symptoms caused by contraction of smooth muscles, circulatory diseases or epilepsy | 28 | 1992 | |
|
|||
5338770 Gas permeable thrombo-resistant coatings and methods of manufacture | 71 | 1990 | |
|
|||
4491574 Reduction of high dose aspirin toxicity by dietary vitamin A | 26 | 1983 | |
|
|||
5362424 Microencapsulation for controlled oral drug delivery system | 68 | 1991 | |
5415619 Method of manufacturing a vascular graft impregnated with polysaccharide derivatives | 55 | 1993 | |
|
|||
5216024 Cell growth inhibitors and methods of treating cancer and cell proliferative diseases | 26 | 1988 | |
|
|||
4784659 Vessel and prosthesis impregnated with diisocyanate crosslinked gelatin | 97 | 1987 | |
|
|||
* 6074659 Therapeutic inhibitor of vascular smooth muscle cells | 275 | 1998 | |
|
|||
5288711 Method of treating hyperproliferative vascular disease | 190 | 1992 | |
5252579 Macrocyclic immunomodulators | 106 | 1993 | |
5302584 Carbamates of rapamycin | 126 | 1993 | |
5387680 C-22 ring stabilized rapamycin derivatives | 56 | 1993 | |
5411967 Carbamates of rapamycin | 76 | 1994 | |
5504091 Biotin esters of rapamycin | 90 | 1994 | |
5516781 Method of treating restenosis with rapamycin | 236 | 1994 | |
5491159 2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-oxazoles as anti-atherosclerotic agents | 20 | 1994 | |
5498775 Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation | 33 | 1994 | |
5563145 Rapamycin 42-oximes and hydroxylamines | 82 | 1994 | |
5525610 42-Epi-rapamycin and pharmaceutical compositions thereof | 67 | 1995 | |
5563146 Method of treating hyperproliferative vascular disease | 146 | 1995 | |
5646160 Method of treating hyperproliferative vascular disease with rapamycin and mycophenolic acid | 106 | 1995 | |
5665728 Method of treating hyperproliferative vascular disease | 89 | 1995 | |
5677295 Rapamycin 42-oximes and hydroxylamines | 9 | 1996 | |
|
|||
5332584 Microcapsules | 46 | 1991 | |
|
|||
5393785 Therapeutic antiestrogens | 37 | 1992 | |
|
|||
5571714 Monoclonal antibodies which bind both transforming growth factors .beta.1 and .beta.2 and methods of use | 73 | 1991 | |
5462925 Transforming growth factor .beta.2,3 | 18 | 1992 | |
5658883 Biologically active TGF-.beta.1 peptides | 9 | 1995 | |
5767079 Method of treating ophthalmic disorders using TGF -.beta. | 67 | 1996 | |
|
|||
4994033 Intravascular drug delivery dilatation catheter | 494 | 1989 | |
5009659 Fiber tip atherectomy catheter | 257 | 1989 | |
5064435 Self-expanding prosthesis having stable axial length | 1256 | 1990 | |
5222971 Temporary stent and methods for use and manufacture | 440 | 1990 | |
5304121 Drug delivery system making use of a hydrogel polymer coating | 756 | 1991 | |
5197977 Drug delivery collagen-impregnated synthetic vascular graft | 414 | 1992 | |
5234456 Hydrophilic stent | 600 | 1992 | |
5449382 Minimally invasive bioactivated endoprosthesis for vessel repair | 459 | 1994 | |
6515009 Therapeutic inhibitor of vascular smooth muscle cells | 108 | 1995 | |
5811447 Therapeutic inhibitor of vascular smooth muscle cells | 240 | 1995 | |
5578075 Minimally invasive bioactivated endoprosthesis for vessel repair | 289 | 1995 | |
6171609 Therapeutic inhibitor of vascular smooth muscle cells | 221 | 1995 | |
5837313 Drug release stent coating process | 828 | 1996 | |
6120536 Medical devices with long term non-thrombogenic coatings | 714 | 1996 | |
* 5733925 Therapeutic inhibitor of vascular smooth muscle cells | 507 | 1996 | |
5735897 Intravascular stent pump | 367 | 1997 | |
* 5981568 Therapeutic inhibitor of vascular smooth muscle cells | 370 | 1997 | |
6306421 Therapeutic inhibitor of vascular smooth muscle cells | 120 | 1997 | |
5980972 Method of applying drug-release coatings | 551 | 1997 | |
6099562 Drug coating with topcoat | 657 | 1997 | |
2002/0032,477 DRUG RELEASE COATED STENT | 125 | 1998 | |
6129757 Implantable members for receiving therapeutically useful compositions | 35 | 1998 | |
6358989 Therapeutic inhibitor of vascular smooth muscle cells | 55 | 1999 | |
* 6268390 Therapeutic inhibitor of vascular smooth muscle cells | 109 | 1999 | |
6783543 Intravascular stent with increasing coating retaining capacity | 144 | 2001 | |
6491938 Therapeutic inhibitor of vascular smooth muscle cells | 120 | 2001 | |
6599928 Therapeutic inhibitor of vascular smooth muscle cells | 60 | 2001 | |
2002/0013,275 Therapeutic inhibitor of vascular smooth muscle cells | 22 | 2001 | |
6569441 Therapeutic inhibitor of vascular smooth muscle cells | 116 | 2001 | |
2002/0091,433 Drug release coated stent | 274 | 2001 | |
* 6663881 Therapeutic inhibitor of vascular smooth muscle cells | 98 | 2001 | |
6656162 Implantable drug delivery stents | 246 | 2002 | |
6720350 Therapeutic inhibitor of vascular smooth muscle cells | 108 | 2002 | |
|
|||
4762129 Dilatation catheter | 698 | 1986 | |
4922905 Dilatation catheter | 812 | 1988 | |
|
|||
5216115 Polyarylate containing derivatives of the natural amino acid L-tyrosine | 86 | 1992 | |
5877224 Polymeric drug formulations | 308 | 1995 | |
|
|||
5362718 Rapamycin hydroxyesters | 202 | 1994 | |
|
|||
5229495 Substantially pure receptor like TGF-.beta. 1 binding molecules and uses thereof | 48 | 1991 | |
|
|||
4973601 Control of insects by fungal tremorgenic mycotoxins | 17 | 1988 | |
5019504 Production of taxol or taxol-like compounds in cell culture | 79 | 1989 | |
|
|||
5733303 Flexible expandable stent | 417 | 1995 | |
5843120 Flexible-expandable stent | 307 | 1997 | |
5972018 Flexible expandable stent | 175 | 1998 | |
6461381 Flexible expandable stent | 70 | 1999 | |
6443982 Flexible expandable stent | 90 | 2000 | |
|
|||
5464450 Biodegradable drug delivery vascular stent | 326 | 1994 | |
5551954 Biodegradable drug delivery vascular stent | 332 | 1994 | |
5500013 Biodegradable drug delivery vascular stent | 411 | 1995 | |
|
|||
4768507 Intravascular stent and percutaneous insertion catheter system for the dilation of an arterial stenosis and the prevention of arterial restenosis | 790 | 1987 | |
|
|||
5262451 Multifunctional thrombo-resistant coatings and methods of manufacture | 68 | 1988 | |
5182317 Multifunctional thrombo-resistant coatings and methods of manufacture | 113 | 1991 | |
|
|||
6168619 Intravascular stent having a coaxial polymer member and end sleeves | 144 | 1998 | |
|
|||
5232911 Mixture of a non-covalent heterodimer complex and a basic amphiphatic peptide as cytotoxic agent | 24 | 1991 | |
|
|||
4959355 Method of inhibiting osmotic water flow | 15 | 1987 | |
5019096 Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same | 684 | 1988 | |
|
|||
5185260 Method for distinguishing normal and transformed cells using G1 kinase inhibitors | 48 | 1991 | |
|
|||
5047431 1,1,2-triphenylbut-1-ene derivatives | 72 | 1990 | |
5254594 Remedies for bone diseases | 72 | 1992 | |
|
|||
5401730 Method for reducing platelet aggregation | 38 | 1993 | |
|
|||
4689046 Heart valve prosthesis | 48 | 1985 | |
|
|||
5496557 Article for the controlled delivery of an active substance, comprising a hollow space fully enclosed by a wall and filled in full or in part with one or more active substances | 43 | 1993 | |
|
|||
5399352 Device for local drug delivery and methods for using the same | 71 | 1993 | |
5383928 Stent sheath for local drug delivery | 418 | 1993 | |
5523092 Device for local drug delivery and methods for using the same | 184 | 1994 | |
|
|||
6087479 Localized use of nitric oxide-adducts to prevent internal tissue damage | 109 | 1995 | |
|
|||
5576345 Method and means for inhibiting posterior capsule opacification | 23 | 1996 | |
|
|||
5262319 Method for obtaining bone marrow free of tumor cells using transforming growth factor .beta.3 | 28 | 1990 | |
5635489 Methods of prevention of oral mucositis with transforming growth factor .beta. | 15 | 1995 | |
|
|||
5380299 Thrombolytic treated intravascular medical device | 467 | 1993 | |
5609629 Coated implantable medical device | 824 | 1995 | |
6096070 Coated implantable medical device | 1006 | 1996 | |
5824049 Coated implantable medical device | 953 | 1996 | |
5873904 Silver implantable medical device | 929 | 1997 | |
|
|||
4994384 Multiplying bovine embryos | 61 | 1987 | |
|
|||
4307111 1-Hydrocarbyloxyphenyl-1,2-diphenylalkene derivatives | 29 | 1980 | |
|
|||
5092877 Radially expandable endoprosthesis | 438 | 1990 | |
5226913 Method of making a radially expandable prosthesis | 419 | 1992 | |
|
|||
5167960 Hirudin-coated biocompatible substance | 77 | 1988 | |
|
|||
5420243 Biologically active TGF-.beta.2 peptides | 24 | 1993 | |
|
|||
4748982 Reinforced balloon dilatation catheter with slitted exchange sleeve and method | 737 | 1987 | |
5496346 Reinforced balloon dilatation catheter with slitted exchange sleeve and method | 431 | 1993 | |
5423885 Stent capable of attachment within a body lumen | 486 | 1993 | |
5443458 Multilayered biodegradable stent and method of manufacture | 407 | 1993 | |
5421955 Expandable stents and method for making same | 756 | 1994 | |
5629077 Biodegradable mesh and film stent | 317 | 1994 | |
5637113 Polymer film for wrapping a stent structure | 501 | 1994 | |
5605696 Drug loaded polymeric material and method of manufacture | 718 | 1995 | |
5632840 Method of making metal reinforced polymer stent | 269 | 1995 | |
5626600 Reinforced balloon dilatation catheter with slitted exchange sleeve and method | 184 | 1995 | |
6066167 Expandable stents | 144 | 1998 | |
6488694 Stent delivery system | 167 | 1999 | |
6527789 Stent delivery system | 123 | 1999 | |
6309412 Expandable stents and method for making same | 64 | 2000 | |
6395326 Apparatus and method for depositing a coating onto a surface of a prosthesis | 562 | 2000 | |
6432133 Expandable stents and method for making same | 99 | 2000 | |
6596022 Expandable stents and method for making same | 70 | 2001 | |
6485511 Expandable stents and method for making same | 75 | 2001 | |
6616765 Apparatus and method for depositing a coating onto a surface of a prosthesis | 257 | 2002 | |
6689159 Expandable stents and method for making same | 57 | 2003 | |
|
|||
5643580 Biocompatible coating, medical device using the same and methods | 73 | 1994 | |
|
|||
6074337 Combination radioactive and temperature self-regulating thermal seed implant for treating tumors | 24 | 1998 | |
6497647 Radiation and thermal energy source | 29 | 2001 | |
|
|||
5099504 Thickness/density mesuring apparatus | 15 | 1989 | |
|
|||
5639738 Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs | 26 | 1992 | |
6022866 Use of hyaluronic acid and forms to prevent arterial restenosis | 43 | 1995 | |
5990095 Use of hyaluronic acid and forms to prevent arterial restenosis | 18 | 1995 | |
|
|||
6086910 Food supplements | 32 | 1997 | |
|
|||
4332791 Toothpaste active against plaque comprising a copper compound and a silica polishing agent | 50 | 1981 | |
4339429 Toothpaste active against plaque comprising a copper compound and a plastic polishing agent | 42 | 1981 | |
4824661 Composition for oral hygiene | 31 | 1986 | |
|
|||
5308622 Treatment of vascular injury | 60 | 1992 | |
|
|||
5407609 Microencapsulation process and products therefrom | 259 | 1993 | |
|
|||
4760051 Use of GHL-Cu as a wound-healing and anti-inflammatory agent | 54 | 1985 | |
5023237 Methods and compositions for healing ulcers | 40 | 1989 | |
5145838 Methods and compositions for healing ulcers | 24 | 1991 | |
|
|||
5120535 Oncostatin M and novel compositions having anti-neoplastic activity | 46 | 1987 | |
|
|||
5519042 Method of treating hyperproliferative vascular disease | 38 | 1994 | |
|
|||
4512762 Method of treatment of atherosclerosis and a balloon catheter for same | 273 | 1982 | |
4577636 Method for diagnosis of atherosclerosis | 88 | 1984 | |
5226430 Method for angioplasty | 145 | 1991 | |
|
|||
5385935 Method for the inhibition of restenosis associated with coronary intervention | 40 | 1993 | |
|
|||
5651627 Nib conversion unit | 23 | 1996 | |
|
|||
5948639 TGF-.beta. pathway genes | 19 | 1997 | |
|
|||
5283257 Method of treating hyperproliferative vascular disease | 107 | 1992 | |
5821234 Inhibition of proliferation of vascular smooth muscle cell | 30 | 1993 | |
|
|||
5147332 Multi-valve catheter for improved reliability | 100 | 1991 | |
|
|||
6042875 Drug-releasing coatings for medical devices | 437 | 1999 | |
|
|||
5208238 Agents for potentiating the effects of antitumor agents and combating multiple drug resistance | 28 | 1992 | |
5346897 Agents for potentiating the effects of antitumor agents and combating multiple drug resistance | 29 | 1992 | |
5364843 Agents for potentiating the effects of antitumor agents and combating multiple drug resistance | 31 | 1992 | |
5395610 Agents for potentiating the effects of antitumor agents and combating multiple drug resistance | 28 | 1993 | |
|
|||
5053048 Thromboresistant coating | 241 | 1990 | |
|
|||
5308862 Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation | 58 | 1993 | |
|
|||
5043335 Indolocarbazoles and the use thereof | 67 | 1990 |
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