US Patent No: 8,067,022 - Analytics, PDF, Full Text and PAIR Access

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Therapeutic inhibitor of vascular smooth muscle cells

ALSO PUBLISHED AS: 20020013275

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Abstract

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Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOSTON SCIENTIFIC SCIMED, INC.MAPLE GROVE, MN4920

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anderson, Peter G Pittsford, NY 20 907
Kunz, Lawrence L - 37 2052

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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Other [Check patent profile for assignment information] (31)
4,233,968 IUD Arrangement 37 1978
4,315,028 Method of treatment of rheumatoid arthritis 22 1979
4,487,780 Method of treatment of rheumatoid arthritis 23 1982
4,613,665 Process for covalent coupling for the production of conjugates, and polysaccharide containing products thereby obtained 126 1983
4,678,466 Internal medication delivery method and vehicle 32 1985
4,840,939 Treatment of cancer with phlorizin and its derivatives 29 1987
4,824,436 Method for the prevention of restenosis 243 1987
4,853,377 Method and composition for increasing production of serotonin 17 1988
5,002,531 Dilation catheter with an inflatable balloon 178 1988
4,968,350 Process for preparing a powder of water-insoluble polymer which can be redispersed in a liquid phase, the resulting powder and utilization thereof 42 1988
5,199,939 Radioactive catheter 270 1990
5,040,548 Angioplasty mehtod 410 1990
5,061,273 Angioplasty apparatus facilitating rapid exchanges 488 1990
5,163,952 Expandable polymeric stent with memory and delivery apparatus and method 582 1990
5,180,366 Apparatus and method for angioplasty and for preventing re-stenosis 185 1990
5,232,444 Dilatation catheter 272 1991
5,216,021 Analgesic method 11 1991
5,258,020 Method of using expandable polymeric stent with memory 291 1992
5,288,735 Treatment of glaucoma 26 1992
5,342,348 Method and device for treating and enlarging body lumens 476 1992
5,290,271 Surgical implant and method for controlled release of chemotherapeutic agents 215 1993
5,451,233 Angioplasty apparatus facilitating rapid exchanges 268 1994
5,470,876 Topical sod for treating hair loss 26 1994
5,470,883 Method of treating peripheral vasoconstriction with tamoxifen citrate 30 1994
5,693,607 Uses of TGF-.beta. receptor fragment as a therapeutic agent 25 1994
5,541,174 Analgesic method 13 1995
5,521,171 Anti-inflammatory and anti-ulcer compounds and process 11 1995
5,639,274 Integrated catheter system for balloon angioplasty and stent delivery 160 1995
5,749,888 Method of using angioplasty apparatus facilitating rapid exchanges 70 1995
6,575,993 Angioplasty apparatus facilitating rapid exchanges 85 1995
6,036,715 Angioplasty apparatus facilitating rapid exchanges 111 1997

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