US Patent No: 8,067,022 - Analytics, PDF, Full Text and PAIR Access

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Therapeutic inhibitor of vascular smooth muscle cells

ALSO PUBLISHED AS: 20020013275

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Abstract

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Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOSTON SCIENTIFIC SCIMED, INC.MAPLE GROVE, MN4583

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anderson, Peter G Pittsford, NY 20 933
Kunz, Lawrence L - 37 2120

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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5,457,116 Methods of inhibiting uterine fibrosis 32 1993
5,461,065 Methods for inhibiting endometriosis 26 1993
5,482,950 Methods for lowering serum cholesterol 16 1993
5,480,904 Methods for inhibiting uterine fibrosis 17 1993
5,389,670 Methods of inhibiting the symptoms of premenstrual syndrome/late luteal phase dysphoric disorder 39 1993
5,439,923 Method of inhibiting seborrhea and acne 26 1993
5,439,931 Method for increasing libido in post-menopausal women 27 1993
5,441,965 Methods of inhibiting thrombin 32 1993
5,441,966 Methods of inhibiting Turner's syndrome 24 1993
5,446,053 Methods of inhibiting dysfunctional uterine bleeding 28 1993
5,447,941 Methods of inhibiting pulmonary hypertensive diseases with raloxifene and related benzothiophenes 29 1993
5,451,589 Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism 20 1993
5,451,590 Methods of inhibiting sexual precocity 20 1993
5,461,064 Methods of inhibiting atrophy of the skin and vagina 24 1993
5,462,949 Methods of inhibiting fertility in women 24 1993
5,462,950 Methods of treating menstrual symptoms and compositions therefore 33 1993
5,492,927 Non-peptide tachykinin receptor antagonists to treat allergy 37 1993
5,521,198 Methods of inhibiting autoimmune diseases 19 1993
5,552,415 Method of inhibiting Alzheimer's Disease 32 1993
5,574,047 Methods of inhibiting imperfect tissue repair 14 1993
5,393,763 Methods for inhibiting bone loss 92 1994
5,478,847 Methods of use for inhibiting bone loss and lowering serum cholesterol 28 1994
5,384,332 Methods for inhibiting aortal smooth muscle cell proliferation and restenosis with 1,1,2-triphenylbut-1-ene derivatives 58 1994
5,426,123 Method for lowering serum cholesterol with 1,1,2-triphenylbut-1-ene derivatives 23 1994
5,455,275 Methods for inhibiting endometriosis and uterine fibroid disease with 1,1,2-triphenylbut-1-ene derivatives 37 1994
5,466,810 2-amino-3-aroyl-benzo[.beta.]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[.beta.]thiophenes 23 1994
5,434,166 Methods of inhibiting demyelinating and desmyelinating diseases 26 1994
5,496,828 Methods of inhibiting ulcerative mucositis 25 1994
5,457,117 Method for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[B][2-(piperidin-1-yl)ethoxyphenylimethanone hydrochloride 38 1994
5,453,442 Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease 28 1994
5,567,713 Hypoglycemic agents 18 1995
5,489,587 Benzofurans used to inhibit bone loss 21 1995
5,571,808 Method for treating smoking-related bone loss 10 1995
5,484,808 Methods of inhibiting cell-cell adhesion 32 1995
5,510,370 Parathyroid hormone and raloxifene for increasing bone mass 63 1995
5,525,624 Non-peptide tachykinin receptor antagonists to treat psycological disorder 22 1995
5,686,467 Methods of inhibiting imperfect tissue repair 12 1995
5,686,476 Methods of inhibiting Alzheimer's Disease 24 1995
5,610,166 Methods for inhibiting angiogenesis 17 1995
5,563,054 Process for preparation of benzo[B]thiophene glucuronides 14 1995
5,462,937 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 32 1995
5,492,926 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 20 1995
5,496,851 Methods of inhibiting cell-cell adhesion 18 1995
5,508,292 Methods of inhibiting thrombin 22 1995
5,534,527 Methods for inhibiting bone loss by treating with aroylbenzothiophenes and estrogen 27 1995
5,610,168 Methods of use for inhibiting bone loss and lowering serum cholesterol 13 1995
5,641,790 Methods of use for inhibiting bone loss and lowering serum cholesterol 25 1995
5,688,813 Methods of inhibiting thrombin 12 1995
5,484,798 Benzothiopene compounds, compositions, and method of inhibiting restenosis 35 1995
5,492,921 Benzothiophene compounds, compositions, and methods for inhibiting aortal smooth muscle proliferation 11 1995
5,484,795 Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting restenosis 40 1995
5,484,796 Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting aortal smooth muscle cell proliferation 14 1995
5,484,797 Naphthly compounds, intermediates, processes, compositions, and method for inhibiting endometrosis 18 1995
5,622,975 Methods for inhibiting vascular smooth muscle cell migration 27 1995
5,492,922 Benzothiophene compounds intermediate compositions and methods for inhibiting aortal smooth muscle proliferation 41 1995
5,521,172 Methods for lowering serum cholesterol 7 1995
5,552,433 Method for lowering serum cholesterol 8 1995
5,556,876 Methods for lowering serum cholesterol 5 1995
5,652,259 Methods of inhibiting Alzheimer's disease 11 1996
5,726,186 Pentacyclic compounds, intermediates, processes, compositions, and methods 10 1996
5,747,510 Pharmaceutical unit dosage formulations 20 1997
 
NOVO PHARMACEUTICAL CORPORATION (1)
5,189,046 Protein kinase C modulators 45 1991
 
ORION-YHTYMA OY (1)
5,491,173 Tri-phenyl alkene derivatives and their preparation and use 44 1994
 
FIDIA S.P.A. (1)
5,416,205 New esters of alginic acid 14 1993
 
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (1)
5,126,348 Bioavailability enhancers 26 1989
 
JOHNSON MATTHEY, INC. (1)
5,100,885 Copper radiosensitizers 19 1989
 
CENTOCOR, INC. (1)
5,026,537 Methods for imaging atherosclerotic plaque 53 1989
 
MERCK SHARP & DOHME CORP. (1)
5,441,734 Metal-interferon-alpha crystals 43 1993
 
Elizabeth-Hata International, Inc. (1)
5,391,378 Two-part medicinal tablet and method of manufacture 31 1993
 
CORDIS CORPORATION (12)
4,739,762 Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft 1124 1986
5,102,417 Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft 851 1988
4,994,071 Bifurcating stent apparatus and method 961 1989
5,049,132 Balloon catheter for delivering therapeutic agents 388 1990
5,195,984 Expandable intraluminal graft 650 1991
5,213,576 Therapeutic porous balloon catheter 284 1991
6,146,358 Method and apparatus for delivery of therapeutic agent 149 1992
5,902,332 Expandable intraluminal graft 172 1992
5,486,357 Radiofrequency plasma biocompatibility treatment of inside surfaces 33 1993
5,356,433 Biocompatible metal surfaces 337 1993
5,863,285 Balloon catheter with radioactive means 73 1997
2004/0236,416 Increased biocompatibility of implantable medical devices 63 2004
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (3)
5,342,926 Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport 15 1993
5,407,658 Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport 16 1994
5,583,153 Use of taxol in the treatment of rheumatoid arthritis 41 1994
 
Health Maintenance Programs, Inc. (1)
5,326,757 Pharmaceutically active antioxidant containing composition and the method of its use to prevent and treat restenosis following angioplasty 82 1993
 
CONSIGLIO NAZIONALE DELLE RICERCHE (1)
4,767,758 Pharmaceutical compositions containing thiophene compounds, and new thiophene compounds 13 1987
 
QUADRA LOGIC TECHNOLOGIES INC. (1)
5,422,362 Method to inhibit restenosis 57 1993
 
UNIVERSITY OF WASHINGTON (1)
5,521,191 Method for treatment of arterial stenosis 20 1994
 
OLYMPUS OPTICAL CO., LTD. (1)
5,318,779 Drug-impregnated ceramic 28 1990
 
ORION CORPORATION (3)
4,696,949 Novel tri-phenyl alkane and alkene derivatives and their preparation and use 52 1986
4,996,225 Tri-phenyl alkane derivatives and their oestrogenic, anti-oestrogenic and progestanic uses 30 1989
5,605,700 Topical administration of toremifene and its metabolites 26 1994
 
DUKE UNIVERSITY (1)
5,527,337 Bioabsorbable stent and method of making the same 414 1994
 
Genentech, Inc. (8)
5,108,989 Method of predisposing mammals to accelerated tissue repair 65 1990
5,208,019 Use of gamma-interferon for the treatment of vascular stenosis 40 1991
5,118,791 Biologically active polypeptides based on transforming growth factor-.beta. 33 1991
5,216,126 Receptor polypeptides and their production and uses 80 1991
5,166,191 Use of relaxin in cardiovascular therapy 31 1991
5,268,455 Process for making biologically active polypeptides based on transforming growth factor-.beta.sequences 20 1992
5,284,763 Nucleic acid encoding TGF-.beta. and its uses 37 1992
5,482,851 Nucleic acid encoding TGF-.beta. and its uses 8 1993
 
HEMAGEN/PFC A LIMITED PARTNERSHIP OF CALIFORNIA (1)
5,304,325 Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use 45 1991
 
BIOCOMPATIBLES UK LIMITED (1)
5,496,581 Polymeric coating 24 1993
 
HERITAGE TECHNOLOGIES, LLC (1)
5,451,414 Micronutrient supplement 10 1994
 
ENDORECHERCHE, A CANADIAN CORPORATION (1)
5,395,842 Anti-estrogenic compounds and compositions 111 1991
 
ENDOTEX INTERNATIONAL SYSTEMS, INC. (1)
5,824,054 Coiled sheet graft stent and methods of making and use 169 1997
 
ABBOTT CARDIOVASCULAR SYSTEMS INC. (2)
5,514,154 Expandable stents 681 1994
6,656,216 Composite stent with regioselective material 195 2001
 
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (2)
5,260,224 Therapeutic uses of actin-binding compounds 35 1991
5,358,844 Preservation of blood platelets 41 1993
 
MATRIX PHARMACEUTICAL, INC. (1)
5,597,578 TGF-.beta. protein compositions for inhibition of cell proliferation 37 1994
 
VALEANT INTERNATIONAL BERMUDA (1)
5,439,689 Diltiazem formulation 39 1993
 
SRI INTERNATIONAL (1)
5,354,562 Process for preparing micronized polypeptide drugs 111 1993
 
ZINPRO CORPORATION (2)
4,900,561 Copper complexes of alpha-amino acids that contain terminal amino groups, and their use as nutritional supplements 25 1989
4,956,188 Copper complexes with alpha hydroxy organic acids and their use as nutritional supplements 28 1989
 
Shepherd Patents S.A. (1)
4,954,126 Prosthesis comprising an expansible or contractile tubular body 736 1989
 
ACDS TECHNOLOGIES, INC. (1)
5,424,331 Pharmaceutical compositions and dietary soybean food products for the prevention of osteoporosis 78 1994
 
ANGIOTECH PHARMACEUTICALS, INC. (2)
6,110,483 Adherent, flexible hydrogel and medicated coatings 317 1997
6,544,544 Anti-angiogenic compositions and methods of use 135 2001
 
PHARMETRIX, MENLO PARK (1)
* 4,919,939 Periodontal disease treatment system 176 1988
 
ANGIOTECH BIOCOATINGS CORP. (1)
5,716,981 Anti-angiogenic compositions and methods of use 713 1995
 
ALKERMES PHARMA IRELAND LIMITED (1)
5,346,702 Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization 103 1992
 
NIPPON KAYAKU KABUSHIKI KAISHA (1)
5,296,492 Certain chroman derivatives useful for treating symptoms caused by contraction of smooth muscles, circulatory diseases or epilepsy 28 1992
 
CARDIOPULMONICS, A CORP OF UTAH (1)
5,338,770 Gas permeable thrombo-resistant coatings and methods of manufacture 67 1990
 
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (2)
5,362,424 Microencapsulation for controlled oral drug delivery system 66 1991
5,415,619 Method of manufacturing a vascular graft impregnated with polysaccharide derivatives 53 1993
 
BAYLOR COLLEGE OF MEDICINE (1)
5,216,024 Cell growth inhibitors and methods of treating cancer and cell proliferative diseases 26 1988
 
INTERMEDICAT GMBH, GERLISWILSTRASSE 74, CH-6020 EMMENBRUCKE, SWITZERLAND, (1)
4,784,659 Vessel and prosthesis impregnated with diisocyanate crosslinked gelatin 95 1987
 
NoeRx Corporation (1)
* 6,074,659 Therapeutic inhibitor of vascular smooth muscle cells 222 1998
 
A DIVISION OF LOUISIANA TECH UNIVERSITY FOUNDATION, INC. (1)
4,491,574 Reduction of high dose aspirin toxicity by dietary vitamin A 25 1983
 
WYETH (15)
5,288,711 Method of treating hyperproliferative vascular disease 160 1992
5,252,579 Macrocyclic immunomodulators 80 1993
5,302,584 Carbamates of rapamycin 86 1993
5,387,680 C-22 ring stabilized rapamycin derivatives 31 1993
5,411,967 Carbamates of rapamycin 40 1994
5,504,091 Biotin esters of rapamycin 53 1994
5,516,781 Method of treating restenosis with rapamycin 192 1994
5,491,159 2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-oxazoles as anti-atherosclerotic agents 19 1994
5,498,775 Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation 33 1994
5,563,145 Rapamycin 42-oximes and hydroxylamines 48 1994
5,525,610 42-Epi-rapamycin and pharmaceutical compositions thereof 41 1995
5,563,146 Method of treating hyperproliferative vascular disease 110 1995
5,646,160 Method of treating hyperproliferative vascular disease with rapamycin and mycophenolic acid 97 1995
5,665,728 Method of treating hyperproliferative vascular disease 80 1995
5,677,295 Rapamycin 42-oximes and hydroxylamines 9 1996
 
SYNGENTA CROP PROTECTION, INC. (1)
5,332,584 Microcapsules 42 1991
 
Endorecherche, Inc. (1)
5,393,785 Therapeutic antiestrogens 37 1992
 
CELTRIX PHARMACEUTICALS, INC. (4)
5,571,714 Monoclonal antibodies which bind both transforming growth factors .beta.1 and .beta.2 and methods of use 46 1991
5,462,925 Transforming growth factor .beta.2,3 18 1992
5,658,883 Biologically active TGF-.beta.1 peptides 8 1995
5,767,079 Method of treating ophthalmic disorders using TGF -.beta. 45 1996
 
BOSTON SCIENTIFIC SCIMED, INC. (33)
4,994,033 Intravascular drug delivery dilatation catheter 401 1989
5,009,659 Fiber tip atherectomy catheter 203 1989
5,064,435 Self-expanding prosthesis having stable axial length 1051 1990
5,222,971 Temporary stent and methods for use and manufacture 374 1990
5,304,121 Drug delivery system making use of a hydrogel polymer coating 534 1991
5,197,977 Drug delivery collagen-impregnated synthetic vascular graft 373 1992
5,234,456 Hydrophilic stent 521 1992
5,449,382 Minimally invasive bioactivated endoprosthesis for vessel repair 388 1994
6,515,009 Therapeutic inhibitor of vascular smooth muscle cells 70 1995
5,811,447 Therapeutic inhibitor of vascular smooth muscle cells 199 1995
5,578,075 Minimally invasive bioactivated endoprosthesis for vessel repair 265 1995
6,171,609 Therapeutic inhibitor of vascular smooth muscle cells 192 1995
5,837,313 Drug release stent coating process 690 1996
6,120,536 Medical devices with long term non-thrombogenic coatings 586 1996
* 5,733,925 Therapeutic inhibitor of vascular smooth muscle cells 402 1996
5,735,897 Intravascular stent pump 328 1997
* 5,981,568 Therapeutic inhibitor of vascular smooth muscle cells 284 1997
6,306,421 Therapeutic inhibitor of vascular smooth muscle cells 87 1997
5,980,972 Method of applying drug-release coatings 477 1997
6,099,562 Drug coating with topcoat 569 1997
2002/0032,477 DRUG RELEASE COATED STENT 100 1998
6,129,757 Implantable members for receiving therapeutically useful compositions 25 1998
6,358,989 Therapeutic inhibitor of vascular smooth muscle cells 49 1999
* 6,268,390 Therapeutic inhibitor of vascular smooth muscle cells 78 1999
6,783,543 Intravascular stent with increasing coating retaining capacity 130 2001
6,491,938 Therapeutic inhibitor of vascular smooth muscle cells 93 2001
6,599,928 Therapeutic inhibitor of vascular smooth muscle cells 50 2001
2002/0013,275 Therapeutic inhibitor of vascular smooth muscle cells 18 2001
6,569,441 Therapeutic inhibitor of vascular smooth muscle cells 81 2001
2002/0091,433 Drug release coated stent 229 2001
* 6,663,881 Therapeutic inhibitor of vascular smooth muscle cells 68 2001
6,656,162 Implantable drug delivery stents 210 2002
6,720,350 Therapeutic inhibitor of vascular smooth muscle cells 47 2002
 
BOSTON SCIENTIFIC CORPORATION (2)
4,762,129 Dilatation catheter 625 1986
4,922,905 Dilatation catheter 523 1988
 
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (2)
5,216,115 Polyarylate containing derivatives of the natural amino acid L-tyrosine 66 1992
5,877,224 Polymeric drug formulations 270 1995
 
WYETH LLC (1)
5,362,718 Rapamycin hydroxyesters 132 1994
 
LUDWIG INSTITUTE FOR CANCER RESEARCH A CORP. OF NEW YORK (1)
5,229,495 Substantially pure receptor like TGF-.beta. 1 binding molecules and uses thereof 48 1991
 
The United States of America as represented by the Secretary of Agriculture (2)
4,973,601 Control of insects by fungal tremorgenic mycotoxins 17 1988
5,019,504 Production of taxol or taxol-like compounds in cell culture 79 1989
 
MEDINOL LTD. (5)
5,733,303 Flexible expandable stent 349 1995
5,843,120 Flexible-expandable stent 241 1997
5,972,018 Flexible expandable stent 156 1998
6,461,381 Flexible expandable stent 54 1999
6,443,982 Flexible expandable stent 69 2000
 
SCIMED LIFE SYSTEMS, INC. (3)
5,464,450 Biodegradable drug delivery vascular stent 288 1994
5,551,954 Biodegradable drug delivery vascular stent 295 1994
5,500,013 Biodegradable drug delivery vascular stent 341 1995
 
MedInnovations, Inc. (1)
4,768,507 Intravascular stent and percutaneous insertion catheter system for the dilation of an arterial stenosis and the prevention of arterial restenosis 647 1987
 
INNERDYNE, INC. (2)
5,262,451 Multifunctional thrombo-resistant coatings and methods of manufacture 66 1988
5,182,317 Multifunctional thrombo-resistant coatings and methods of manufacture 105 1991
 
Quanam Medical Corporation (1)
6,168,619 Intravascular stent having a coaxial polymer member and end sleeves 128 1998
 
VENTECH RESEARCH, INC. (1)
5,232,911 Mixture of a non-covalent heterodimer complex and a basic amphiphatic peptide as cytotoxic agent 23 1991
 
The Trustees of Columbia University in the City of New York (2)
4,959,355 Method of inhibiting osmotic water flow 15 1987
5,019,096 Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same 594 1988
 
ENERGY, UNITED STATES DEPARTMENT OF (1)
5,185,260 Method for distinguishing normal and transformed cells using G1 kinase inhibitors 48 1991
 
KLINGE PHARMA GMBH (2)
5,047,431 1,1,2-triphenylbut-1-ene derivatives 72 1990
5,254,594 Remedies for bone diseases 71 1992
 
The Hope Heart Institute (1)
5,401,730 Method for reducing platelet aggregation 36 1993
 
SULZER CARBOMEDICS INC. (1)
4,689,046 Heart valve prosthesis 47 1985
 
N.V. ORGANON (1)
5,496,557 Article for the controlled delivery of an active substance, comprising a hollow space fully enclosed by a wall and filled in full or in part with one or more active substances 42 1993
 
EMORY UNIVERSITY (3)
5,399,352 Device for local drug delivery and methods for using the same 65 1993
5,383,928 Stent sheath for local drug delivery 394 1993
5,523,092 Device for local drug delivery and methods for using the same 157 1994
 
NITROMED, INC. (1)
6,087,479 Localized use of nitric oxide-adducts to prevent internal tissue damage 92 1995
 
OSI PHARMACEUTICALS, INC. (2)
5,262,319 Method for obtaining bone marrow free of tumor cells using transforming growth factor .beta.3 28 1990
5,635,489 Methods of prevention of oral mucositis with transforming growth factor .beta. 15 1995
 
MED INSTITUTE, INC. (5)
5,380,299 Thrombolytic treated intravascular medical device 410 1993
5,609,629 Coated implantable medical device 687 1995
6,096,070 Coated implantable medical device 824 1996
5,824,049 Coated implantable medical device 794 1996
5,873,904 Silver implantable medical device 790 1997
 
INFIGEN, INC. (1)
4,994,384 Multiplying bovine embryos 59 1987
 
IMPERIAL CHEMICAL INDUSTRIES PLC (1)
4,307,111 1-Hydrocarbyloxyphenyl-1,2-diphenylalkene derivatives 29 1980
 
CORVITA CORPORATION (2)
5,092,877 Radially expandable endoprosthesis 378 1990
5,226,913 Method of making a radially expandable prosthesis 372 1992
 
PHARMACIA AB (1)
5,576,345 Method and means for inhibiting posterior capsule opacification 23 1996
 
ADVANCED BIO PROSTHETIC SURFACES, LTD. (1)
4,793,348 Balloon expandable vena cava filter to prevent migration of lower extremity venous clots into the pulmonary circulation 450 1986
 
BETH ISRAEL DEACONESS MEDICAL CENTER (1)
5,167,960 Hirudin-coated biocompatible substance 72 1988
 
INNOVENT, INC. (1)
5,420,243 Biologically active TGF-.beta.2 peptides 23 1993
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (20)
4,748,982 Reinforced balloon dilatation catheter with slitted exchange sleeve and method 662 1987
5,496,346 Reinforced balloon dilatation catheter with slitted exchange sleeve and method 330 1993
5,423,885 Stent capable of attachment within a body lumen 438 1993
5,443,458 Multilayered biodegradable stent and method of manufacture 352 1993
5,421,955 Expandable stents and method for making same 654 1994
5,629,077 Biodegradable mesh and film stent 257 1994
5,637,113 Polymer film for wrapping a stent structure 424 1994
5,605,696 Drug loaded polymeric material and method of manufacture 641 1995
5,632,840 Method of making metal reinforced polymer stent 236 1995
5,626,600 Reinforced balloon dilatation catheter with slitted exchange sleeve and method 160 1995
6,066,167 Expandable stents 101 1998
6,488,694 Stent delivery system 138 1999
6,527,789 Stent delivery system 95 1999
6,309,412 Expandable stents and method for making same 56 2000
6,395,326 Apparatus and method for depositing a coating onto a surface of a prosthesis 471 2000
6,432,133 Expandable stents and method for making same 89 2000
6,596,022 Expandable stents and method for making same 55 2001
6,485,511 Expandable stents and method for making same 56 2001
6,616,765 Apparatus and method for depositing a coating onto a surface of a prosthesis 228 2002
6,689,159 Expandable stents and method for making same 44 2003
 
SURFACE GENESIS, INC. (1)
5,643,580 Biocompatible coating, medical device using the same and methods 67 1994
 
ATI MEDICAL, INC. (2)
6,074,337 Combination radioactive and temperature self-regulating thermal seed implant for treating tumors 20 1998
6,497,647 Radiation and thermal energy source 26 2001
 
ADAPTIVE TECHNOLOGIES, INC. (1)
5,099,504 Thickness/density mesuring apparatus 13 1989
 
JAGOTEC AG (3)
5,639,738 Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs 19 1992
6,022,866 Use of hyaluronic acid and forms to prevent arterial restenosis 38 1995
5,990,095 Use of hyaluronic acid and forms to prevent arterial restenosis 15 1995
 
HOWARD FOUNDATION, THE (1)
6,086,910 Food supplements 29 1997
 
Blendax-Werke R. Schneider GmbH & Co. (3)
4,332,791 Toothpaste active against plaque comprising a copper compound and a silica polishing agent 49 1981
4,339,429 Toothpaste active against plaque comprising a copper compound and a plastic polishing agent 42 1981
4,824,661 Composition for oral hygiene 31 1986
 
The Whittier Institute for Diabetes and Endocrinology (1)
5,308,622 Treatment of vascular injury 60 1992
 
BROOKWOOD PHARMACEUTICALS, INC. (1)
5,407,609 Microencapsulation process and products therefrom 221 1993
 
ProCyte Corporation (3)
4,760,051 Use of GHL-Cu as a wound-healing and anti-inflammatory agent 51 1985
5,023,237 Methods and compositions for healing ulcers 39 1989
5,145,838 Methods and compositions for healing ulcers 23 1991
 
ONCOGEN, A WA CORP. (1)
5,120,535 Oncostatin M and novel compositions having anti-neoplastic activity 44 1987
 
SANOFI-AVENTIS DEUTSCHLAND GMBH (1)
5,519,042 Method of treating hyperproliferative vascular disease 38 1994
 
The Beth Israel Hospital Association (3)
4,512,762 Method of treatment of atherosclerosis and a balloon catheter for same 250 1982
4,577,636 Method for diagnosis of atherosclerosis 85 1984
5,226,430 Method for angioplasty 138 1991
 
KISSEI PHARMACEUTICAL CO., LTD. (1)
5,385,935 Method for the inhibition of restenosis associated with coronary intervention 39 1993
 
ESSELTE CORPORATION (1)
5,651,627 Nib conversion unit 22 1996
 
MILLENNIUM PHARMACEUTICALS, INC. (1)
5,948,639 TGF-.beta. pathway genes 12 1997
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (2)
5,283,257 Method of treating hyperproliferative vascular disease 104 1992
5,821,234 Inhibition of proliferation of vascular smooth muscle cell 26 1993
 
C.R. BARD, INC. (1)
5,147,332 Multi-valve catheter for improved reliability 71 1991
 
SCHNEIDER (USA) INC. (1)
6,042,875 Drug-releasing coatings for medical devices 373 1999
 
Burroughs Wellcome Co. (4)
5,208,238 Agents for potentiating the effects of antitumor agents and combating multiple drug resistance 28 1992
5,346,897 Agents for potentiating the effects of antitumor agents and combating multiple drug resistance 29 1992
5,364,843 Agents for potentiating the effects of antitumor agents and combating multiple drug resistance 31 1992
5,395,610 Agents for potentiating the effects of antitumor agents and combating multiple drug resistance 28 1993
 
LIFESHIELD SCIENCES LLC (1)
5,053,048 Thromboresistant coating 221 1990
 
Boehringer Mannheim Pharmaceuticals Corporation - SmithKline Beecham Corp., Ltd. Partnership No. 1 (1)
5,308,862 Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation 58 1993
 
Godecke Aktiengesellschaft (1)
5,043,335 Indolocarbazoles and the use thereof 67 1990
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