Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
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United States of America Patent
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Nov 29, 2011
Grant Date -
Dec 22, 2005
app pub date -
Apr 28, 2005
filing date -
Apr 28, 2004
priority date (Note) -
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Abstract
Crosslinkable compositions are provided that readily crosslink in situ to provide crosslinked biomaterials. The composition contains at least two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. In one embodiment, a first component has nucleophilic groups and a second component has electrophilic groups. Additional components may have nucleophilic or electrophilic groups. Methods for preparing and using the compositions are also provided as are kits for delivery of the compositions. Exemplary uses for the crosslinked compositions include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.
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