ZNF206: regulator of embryonic stem cell self-renewal and pluripotency
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United States of America Patent
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Dec 6, 2011
Grant Date -
Apr 9, 2009
app pub date -
Aug 6, 2008
filing date -
Aug 6, 2007
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Expired
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Abstract
We have identified ZNF206, a novel repressor of human embryonic stem cell (hESC) differentiation. Repressing extra-embryonic endoderm development preserves the pluripotent state of human embryonic stem cells, and, conversely downregulating expression of ZNF206 in hESCs causes them to upregulate the expression of genes associated with the extra-embryonic endodermal lineage, down-regulate genes associated with the pluripotent state, and may lead to the further emergence of genes associated with even more differentiated lineages and phenotypes.
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