Glutamic acid decarboxylase (GAD) chimera and methods of use
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United States of America Patent
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Dec 6, 2011
Grant Date -
Sep 17, 2009
app pub date -
Mar 24, 2009
filing date -
May 31, 2005
priority date (Note) -
Expired
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Abstract
The invention relates to a novel Glutamic Acid Decarboxylase (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the invention discloses a novel composition and related methods for treating neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, epilepsy, and the like, using viral and non-viral delivery systems that deliver therapeutic agents to specific regions of the brain. More specifically, using an adeno-associated viral vector to deliver a nucleotide sequence encoding a novel glutamic acid decarboxylase (GAD) to specific regions of the brain that are over stimulated or disinhibited in various diseases, including neurodegenerative diseases.
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