Diagnosis and treatment of cancer related to human dormancy
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United States of America Patent
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Dec 13, 2011
Grant Date -
Jul 3, 2008
app pub date -
Jan 2, 2008
filing date -
Jan 3, 2007
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Abstract
New devices and methods for diagnosis and compositions and methods for treatment of cancers use combinations of antimicrobial agents and agents that can reverse dormancy and hibernation pathways. We unexpectedly found that surprisingly low doses of anti-hibernation compounds can substantially inhibit cancer cell growth in vitro and can successfully treat cancers, including metastatic cancer. We also unexpectedly found that antimicrobial agents and anti-HDS compounds together can increase the degree of inhibition of cancer cell growth in a synergistic fashion. We conclude that combination therapy with antimicrobial agents and anti-HDS compounds can be effective in treating human patients with cancer.
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