US Patent No: 8,080,534

Number of patents in Portfolio can not be more than 2000

Targeting PAX2 for the treatment of breast cancer

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ALSO PUBLISHED AS: 20100209421
ATTORNEY / AGENT: (SPONSORED)
 

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Abstract

The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the certain embodiments, the method of inhibiting expression of PAX2 is to administrate the subject a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 or by increasing expression of DEFB1 is also provided.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
PHIGENIX, INC.ATLANTA, GA4

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DONALD, Carlton D - 33 1

Cited Art

Patent Info (Count) # Cites Year
 
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REGENTS OF THE UNIVERSITY OF MINNESOTA (1)
5,994,320 Antisense oligonucleotides and methods for treating central nervous system tumors 13 1997
 
RESEARCH CORPORATION TECHNOLOGIES, INC. (1)
6,261,834 Vector for gene therapy 16 1992
 
RESEARCH DEVELOPMENT FOUNDATION (1)
5,650,316 Uses of triplex forming oligonucleotides for the treatment of human diseases 17 1994
 
RIBAPHARM INC. (1)
5,849,903 Antisense oligonucleotides for IL-8 and IL-8 receptor 9 1997
 
SANKYO COMPANY, LIMITED (1)
5,631,115 Looped, hairpin ribozyme 10 1994
 
SHIZUYA, HIROAKI (1)
5,317,098 Non-radioisotope tagging of fragments 72 1986
 
SMITHKLINE BEECHAM CORPORATION (1)
5,792,431 Multi-reactor synthesizer and method for combinatorial chemistry 49 1996
 
STERLING WINTHROP, INC. (1)
5,576,427 Acyclic nucleoside analogs and oligonucleotide sequences containing them 96 1995
 
SYNGENE, INC. (1)
4,948,882 Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis 166 1987
 
SYNSORB BIOTECH, INC. (1)
5,965,719 Combinatorial synthesis of carbohydrate libraries 10 1997
 
SYNTEX (U.S.A.) INC. (1)
4,897,355 N[.omega.,(.omega.-1)-dialkyloxy]- and N-[.omega.,(.omega.-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor 248 1987
 
SYNTHETIC GENETICS, INC., A CORP. OF CA (1)
4,904,582 Novel amphiphilic nucleic acid conjugates 134 1987
 
TAIHO PHARMACEUTICAL CO., LTD. (1)
5,869,246 Triplex Oligonucleotides targeted to p120 9 1996
 
TAOGOSEI CO., LTD. (1)
6,057,437 Antisense nucleic acid compounds inhibiting vascular endothelial growth factor 12 1998
 
THE CURATORS OF THE UNIVERSITY OF MISSOURI (1)
5,792,613 Method for obtaining RNA aptamers based on shape selection 30 1996
 
THE JOHNS HOPKINS UNIVERSITY (1)
5,834,185 Formation of triple helix complexes of single stranded nucleic acids using nucleoside oligomers which comprise pyrimidine analogs, triple helix complexes formed thereby and oligomers used in their formation 12 1994
 
THE PENN STATE RESEARCH FOUNDATION (1)
5,834,195 Method for identifying members of combinatorial libraries 21 1996
 
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (1)
5,292,873 Nucleic acids labeled with naphthoquinone probe 63 1989
 
TOAGOSEI CO., LTD. (1)
5,770,715 Hammerhead-like nucleic acid analogues and their synthesis 10 1996
 
TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (1)
5,556,762 Scanning synthetic peptide combinatorial libraries: oligopeptide mixture sets having a one predetermined residue at a single, predetermined position, methods of making and using the same 65 1992
 
UNIVERSITE DE MONTREAL (1)
5,861,288 Catalytic DNA 15 1993
 
UNIVERSITY OF HAWAII (1)
5,683,899 Methods and compositions for combinatorial-based discovery of new multimeric molecules 32 1996
 
UNIVERSITY OF MANITOBA (1)
6,046,319 Antisense oligodeoxynucleotides regulating expression of TNF-.alpha. 29 1998
 
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (1)
5,652,107 Diagnostic assays and kits for RNA using RNA binary probes and a ribozyme ligase 26 1996
 
UNIVERSITY OF MONTREAL, A CORP. OF QUEBEC (1)
5,652,094 Nucleozymes 14 1992
 
UNIVERSITY OF ROCHESTER (1)
5,683,874 Single-stranded circular oligonucleotides capable of forming a triplex with a target sequence 19 1995
 
UNIVERSITY OF VIRGINIA (1)
5,519,126 Oligonucleotide N-alkylphosphoramidates 119 1993
 
VERSICOR INC. (1)
6,025,371 Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones 10 1996
 
WARNER-LAMBERT COMPANY (1)
5,877,022 Ribozymes targeted to APO(a) RNA 11 1996
 
WILDERNESS PLACE HLDGS LLC DON CAMPBELL PRESIDENT HAMBRECHT & QUIST GUARANTY FINANCE LP (1)
5,633,133 Ligation with hammerhead ribozymes 21 1994
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (8)
4,824,941 Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems 57 1988
5,272,250 Boronated phosphoramidate compounds 63 1992
5,539,082 Peptide nucleic acids 293 1993
5,627,158 Antisense oligonucleotides of human regulatory subunit RI-.sub..alpha. of camp dependent protein kinases for the treatment of cancer 16 1993
5,691,317 Antisense oligonucleotides of human regulatory subunit RI-alpha of cAMP dependent protein kinases for the treatment of cancer 10 1995
5,616,466 Ribozyme-mediated inhibition of bovine leukemia virus 8 1995
5,719,262 Peptide nucleic acids having amino acid side chains 144 1996
5,856,463 PSKH-1 ribozymes 8 1996

Patent Citation Ranking

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BLH ELECTRONICS, INC. (1)
5,419,210 High capacity weigh module 6 1994

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