Heparin conjugates and methods
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United States of America Patent
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Jan 3, 2012
Grant Date -
Jun 11, 2009
app pub date -
Aug 7, 2008
filing date -
Jun 29, 2007
priority date (Note) -
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Abstract
Heparin conjugates and methods of making and use thereof are disclosed. An illustrative heparin conjugate includes a composition wherein a bile acid is bonded to heparin through the 3-carbon of the bile acid. A spacer may be interposed between the bile acid and the heparin. Another embodiment includes a targeting moiety bonded to the heparin-bile acid conjugate through a spacer. Another illustrative heparin conjugate includes heparin covalently bonded to a sulfonated moiety, such as a naphthalene trisulfonate residue. A method of treating cancer includes administering a heparin conjugate to an individual in need thereof.
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