Thermostable viral polymerases and methods of use
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United States of America Patent
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Jan 10, 2012
Grant Date -
Oct 30, 2008
app pub date -
Oct 6, 2006
filing date -
Oct 6, 2005
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Abstract
Thermostable viral polymerases exhibiting a combination of activities selected from, proofreading (3′-5′) exonuclease activity, nick translating (5′-3′) nuclease activity, synthetic primer-initiated polymerase activity, nick-initiated polymerase activity, reverse transcriptase activity, strand displacement activity, and/or decreased discrimination against incorporation of nucleotide analogs. Also provided are compositions including the polymerases, polynucleotides encoding the polymerases and methods of using the polymerases.
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