US Patent No: 8,103,349

Number of patents in Portfolio can not be more than 2000

Neural electrode treatment

ALSO PUBLISHED AS: 20100094375

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Abstract

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An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ENTEROMEDICS INC.ST PAUL, MN35

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Donders, Adrianus P Founex, CH 43 1951
Knudson, Mark B Shoreview, MN 209 8161
Weijand, Koen J Alfas Del Pi, ES 39 2122

Cited Art Landscape

Patent Info (Count) # Cites Year
 
EnteroMedics Inc. (29)
2004/0172,084 Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) 60 2003
7,489,969 Vagal down-regulation obesity treatment 27 2003
2004/0172,085 Nerve stimulation and conduction block therapy 114 2003
2004/0172,086 Nerve conduction block treatment 62 2003
2004/0176,812 Enteric rhythm management 122 2003
7,167,750 Obesity treatment with electrically induced vagal down regulation 156 2004
7,444,183 Intraluminal electrode apparatus and method 57 2004
2005/0070,970 Movement disorder stimulation with neural block 66 2004
2005/0070,974 Obesity and eating disorder stimulation treatment with neural block 72 2004
7,844,338 High frequency obesity treatment 18 2004
2005/0038,484 Controlled vagal blockage therapy 131 2004
7,613,515 High frequency vagal blockage therapy 31 2005
2005/0131,485 High frequency vagal blockage therapy 117 2005
* 7,672,727 Neural electrode treatment 9 2005
7,822,486 Custom sized neural electrodes 24 2005
2007/0043,400 Neural electrode treatment 21 2005
7,630,769 GI inflammatory disease treatment 13 2007
7,693,577 Irritable bowel syndrome treatment 10 2007
7,720,540 Pancreatitis treatment 10 2007
7,986,995 Bulimia treatment 7 2007
2007/0135,846 Vagal obesity treatment 32 2007
2007/0135,856 Bulimia treatment 26 2007
2007/0135,857 GI inflammatory disease treatment 26 2007
2007/0135,858 Pancreatitis treatment 25 2007
2007/0142,870 Irritable bowel syndrome treatment 25 2007
7,729,771 Nerve stimulation and blocking for treatment of gastrointestinal disorders 12 2007
2008/0021,512 Nerve stimulation and blocking for treatment of gastrointestinal disorders 33 2007
2008/0300,654 IMPLANTABLE THERAPY SYSTEM 32 2007
7,917,226 Antenna arrangements for implantable therapy device 13 2008
 
MEDTRONIC, INC. (26)
5,344,438 Cuff electrode 122 1993
5,861,014 Method and apparatus for sensing a stimulating gastrointestinal tract on-demand 230 1997
6,216,039 Method and apparatus for treating irregular gastric rhythms 91 1997
5,919,216 System and method for enhancement of glucose production by stimulation of pancreatic beta cells 152 1997
6,093,167 System for pancreatic stimulation and glucose measurement 176 1997
5,967,977 Transesophageal medical lead 73 1997
6,091,992 Method and apparatus for electrical stimulation of the gastrointestinal tract 157 1997
6,104,955 Method and apparatus for electrical stimulation of the gastrointestinal tract 155 1997
6,083,249 Apparatus for sensing and stimulating gastrointestinal tract on-demand 213 1998
5,995,872 Method and apparatus for electrical stimulation of the gastrointestinal tract 202 1998
6,097,984 System and method of stimulation for treating gastro-esophageal reflux disease 173 1998
6,135,978 System for pancreatic stimulation and glucose measurement 325 1999
6,308,105 Medical electrical stimulation system using an electrode assembly having opposing semi-circular arms 67 1999
6,238,423 Apparatus and method for treating chronic constipation 128 1999
6,418,346 Apparatus and method for remote therapy and diagnosis in medical devices via interface systems 260 1999
6,612,983 Pancreatic secretion response to stimulation test protocol 91 2000
6,853,862 Gastroelectric stimulation for influencing pancreatic secretions 118 2000
6,261,280 Method of obtaining a measure of blood glucose 95 2000
6,532,388 Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure 195 2000
6,928,320 Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated 171 2001
7,620,454 Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof 17 2003
2004/0193,229 Gastric electrical stimulation for treatment of gastro-esophageal reflux disease 57 2003
2004/0236,381 Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof 57 2003
2004/0236,382 Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof 57 2003
2005/0075,693 Driver circuitry switchable between energy transfer and telemetry for an implantable medical device 46 2004
2006/0247,737 Alignment indication for transcutaneous energy transfer 30 2005
 
CYBERONICS, INC. (25)
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5,188,104 Treatment of eating disorders by nerve stimulation 454 1991
5,269,303 Treatment of dementia by nerve stimulation 346 1991
5,215,086 Therapeutic treatment of migraine symptoms by stimulation 413 1991
5,251,634 Helical nerve electrode 208 1991
5,299,569 Treatment of neuropsychiatric disorders by nerve stimulation 498 1991
5,335,657 Therapeutic treatment of sleep disorder by nerve stimulation 605 1991
5,231,988 Treatment of endocrine disorders by nerve stimulation 423 1991
5,215,089 Electrode assembly for nerve stimulation 198 1991
5,330,515 Treatment of pain by vagal afferent stimulation 366 1992
5,263,480 Treatment of eating disorders by nerve stimulation 402 1992
5,531,778 Circumneural electrode assembly 230 1994
5,571,150 Treatment of patients in coma by nerve stimulation 346 1994
5,540,730 Treatment of motility disorders by nerve stimulation 507 1995
5,707,400 Treating refractory hypertension by nerve stimulation 470 1995
6,587,719 Treatment of obesity by bilateral vagus nerve stimulation 267 1999
6,473,644 Method to enhance cardiac capillary growth in heart failure patients 344 1999
6,609,025 Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation 241 2001
6,622,038 Treatment of movement disorders by near-diaphragmatic nerve stimulation 158 2001
6,600,956 Circumneural electrode assembly 251 2001
7,299,091 Treatment of obesity by bilateral vagus nerve stimulation 35 2003
7,340,306 Treatment of obesity by sub-diaphragmatic nerve stimulation 35 2003
2007/0027,484 Autonomic nerve stimulation to treat a pancreatic disorder 47 2005
7,620,455 Cranial nerve stimulation to treat eating disorders 16 2005
2007/0100,377 Providing multiple signal modes for a medical device 15 2005
 
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (9)
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
6,832,114 Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes 191 2001
7,292,890 Vagus nerve stimulation via unidirectional propagation of action potentials 155 2002
2006/0036,293 Methods for treating gastrointestinal disorders 72 2005
 
NEURO AND CARDIAC TECHNOLOGIES, LLC (8)
6,611,715 Apparatus and method for neuromodulation therapy for obesity and compulsive eating disorders using an implantable lead-receiver and an external stimulator 149 2001
6,760,626 Apparatus and method for treatment of neurological and neuropsychiatric disorders using programmerless implantable pulse generator system 163 2001
6,879,859 External pulse generator for adjunct (add-on) treatment of obesity, eating disorders, neurological, neuropsychiatric, and urological disorders 120 2002
2003/0212,440 Method and system for modulating the vagus nerve (10th cranial nerve) using modulated electrical pulses with an inductively coupled stimulation system 168 2002
7,076,307 Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders 77 2004
2005/0137,644 Method and system for vagal blocking and/or vagal stimulation to provide therapy for obesity and other gastrointestinal disorders 63 2005
2005/0143,787 Method and system for providing electrical pulses for neuromodulation of vagus nerve(s), using rechargeable implanted pulse generator 163 2005
2005/0149,146 Method and system to provide therapy for obesity and other medical disorders, by providing electrical pules to symapthetic nerves or vagal nerve(s) with rechargeable implanted pulse generator 110 2005
 
ALLERGAN, INC. (5)
5,437,291 Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction 226 1993
6,312,708 Botulinum toxin implant 168 2000
6,261,572 Method for treating a pancreatic disorder with a neurotoxin 52 2000
2001/0012,828 Intraspinal botulinum toxin for treating pain 24 2001
2004/0086,531 Methods for treating ulcers and gastroesophageal reflux disease 45 2002
 
ADVANCED NEUROMODULATION SYSTEMS, INC. (4)
6,002,964 Epidural nerve root stimulation 162 1998
2003/0181,958 Electric modulation of sympathetic nervous system 165 2002
2006/0190,053 Neural stimulation for treatment of metabolic syndrome and type 2 diabetes 35 2006
2007/0203,521 Nerve stimulation for treatment of obesity, metabolic syndrome, and type 2 diabetes 23 2007
 
BIO CONTROL MEDICAL (B.C.M.) LTD. (4)
6,684,105 Treatment of disorders by unidirectional nerve stimulation 261 2001
2004/0243,182 Treatment of disorders by unidirectional nerve stimulation 128 2004
7,346,398 Electrode assembly for nerve control 69 2004
2006/0100,668 Selective nerve fiber stimulation 94 2005
 
ACTIVE PROTECTIVE TECHNOLOGIES, INC. (3)
2005/0067,816 Method and apparatus for body impact protection 1 2004
2005/0067,816 Method and apparatus for body impact protection 1 2004
2005/0067,816 Method and apparatus for body impact protection 1 2004
 
CASE WESTERN RESERVE UNIVERSITY (3)
5,199,430 Micturitional assist device 121 1991
6,587,725 Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea 79 2001
7,389,145 Systems and methods for reversibly blocking nerve activity 70 2002
 
CIT GROUP/BUSINESS CREDIT, INC. (3)
4,702,254 Neurocybernetic prosthesis 412 1985
4,867,164 Neurocybernetic prosthesis 378 1987
5,025,807 Neurocybernetic prosthesis 336 1989
 
ENDOVX, INC. (3)
2004/0181,178 Methods and apparatus for treatment of obesity 37 2003
2005/0203,501 Methods and apparatus for treatment of obesity with an ultrasound device movable in two or three axes 46 2005
2006/0015,151 Method of using endoscopic truncal vagoscopy with gastric bypass, gastric banding and other procedures 47 2005
 
BIOCONTROL MEDICAL LTD. (2)
2003/0045,909 Selective nerve fiber stimulation for treating heart conditions 262 2002
2005/0267,542 Techniques for applying, configuring, and coordinating nerve fiber stimulation 80 2005
 
EMORY UNIVERSITY (2)
7,072,720 Devices and methods for vagus nerve stimulation 83 2002
7,142,910 Methods of indirectly stimulating the vagus nerve with an electrical field 58 2004
 
JPMORGAN CHASE BANK, N.A. (2)
2002/0062,071 Manual and automatic probe calibration 6 2001
2002/0062,071 Manual and automatic probe calibration 6 2001
 
METACURE LIMITED (2)
6,571,127 Method of increasing the motility of a GI tract 219 2000
6,993,391 Acute and chronic electrical signal therapy for obesity 40 2003
 
TRANSNEURONIX, INC. (2)
5,423,872 Process and device for treating obesity and syndromes related to motor disorders of the stomach of a patient 307 1993
2002/0072,780 Method and apparatus for intentional impairment of gastric motility and /or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity 105 2001
 
BIOENTERIES CORPORATION (1)
5,601,604 Universal gastric band 243 1993
 
Biotronik Mess-und Therapiegeraete GmbH & Co. (1)
6,292,703 Neural electrode arrangement 114 1999
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
6,826,428 Gastrointestinal electrical stimulation 177 2002
 
CARDIOCOMMAND, INC. (1)
6,148,222 Esophageal catheters and method of use 102 1998
 
CEDARS-SINAI MEDICAL CENTER (1)
6,558,708 Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia 58 2000
 
CENTER FOR INNOVATIVE TECHNOLOGY, THE (1)
5,716,385 Crural diaphragm pacemaker and method for treating esophageal reflux disease 90 1996
 
Cerebral Stimulation, Inc. (1)
5,514,175 Auricular electrical stimulator 125 1994
 
CVRX, INC. (1)
2004/0254,616 Stimulus regimens for cardiovascular reflex control 134 2004
 
DILORENZO BIOMEDICAL, LLC (1)
2003/0018,367 Method and apparatus for neuromodulation and phsyiologic modulation for the treatment of metabolic and neuropsychiatric disease 193 2002
 
EURO-CELTIQUE S.A. (1)
5,747,060 Prolonged local anesthesia with colchicine 121 1996
 
FLINT HILLS SCIENTIFIC, LLC (1)
6,341,236 Vagal nerve stimulation techniques for treatment of epileptic seizures 411 1999
 
FORSCHUNGSZENTRUM JULICH GMBH (1)
2006/0212,089 Device for the desynchronization of neuronal brain activity 30 2004
 
HITACHI GLOBAL STORAGE TECHNOLOGIES JAPAN, LTD. (1)
6,111,715 Storage apparatus using a magnetoresistive head that employs a sense current selected from plural predetermined sense currents 26 1998
 
INAMED DEVELOPMENT COMPANY (1)
5,226,429 Laparoscopic gastric band and method 383 1991
 
INNERCOOL THERAPIES, INC. (1)
6,364,899 Heat pipe nerve cooler 101 1999
 
INTRAPACE, INC. (1)
7,054,690 Gastrointestinal stimulation device 77 2003
 
KNIGHT, MARTHA (1)
5,620,955 Bombesin receptor antagonists and uses thereof 31 1993
 
KOSAN BIOSCIENCES, INC. (1)
2002/0094,962 Motilide compounds 25 2001
 
LEPTOS BIODMEDICAL, INC. (1)
2003/0181,959 Wireless electric modulation of sympathetic nervous system 79 2002
 
MEDERI THERAPEUTICS, INC. (1)
6,405,732 Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors 217 1999
 
MEDICAL UNIVERSITY OF SOUTH CAROLINA (1)
5,830,434 Methods of treating non-insulin dependent diabetes mellitus with pancreatic polypeptide 24 1997
 
MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. (1)
2006/0041,277 Methods and apparatus for renal neuromodulation 79 2005
 
MEDTRONIC TRANSNEURONIX, INC. (1)
6,895,278 Gastric stimulator apparatus and method for use 99 1999
 
Michael J. Jaro (1)
5,836,994 Method and apparatus for electrical stimulation of the gastrointestinal tract 252 1997
 
NDI MEDICAL, LLC (1)
2006/0030,919 Devices, systems, and methods employing a molded nerve cuff electrode 52 2005
 
Neuro and Cardial Technologies, LLC (1)
7,444,184 Method and system for providing therapy for bulimia/eating disorders by providing electrical pulses to vagus nerve(s) 23 2005
 
NEUROPACE, INC. (1)
6,591,137 Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders 188 2000
 
NEUROTRONIC LTEE 11251 RUE NOTRE-DAME EST, MONTREAL, QUEBEC, CANADA H1B 2W2 (1)
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NIDUS MEDICAL, LLC (1)
6,746,474 Apparatus and methods for cooling a region within the body 56 2002
 
PACESETTER, INC. (1)
5,749,907 System and method for identifying and displaying medical data which violate programmable alarm conditions 406 1997
 
PALO ALTO INVESTORS (1)
2005/0143,378 Treatment of conditions through pharmacological modulation of the autonomic nervous system 23 2003
 
SECOND SIGHT MEDICAL PRODUCTS, INC. (1)
2003/0195,601 High-density array of micro-machined electrodes for neural stimulation 41 2002
 
SEPRACOR INC. (1)
6,369,079 Methods for treating irritable bowel syndrome using optically pure (+) norcisapride 25 2000
 
SOLSTICE NEUROSCIENCES, LLC (1)
6,290,961 Method for treating dystonia with botulinum toxin type B 40 2000
 
TECHNOLOGIES INTERNATIONAL INC., UNIVERSITY (1)
6,449,511 Gastrointestinal electrical stimulator having a variable electrical stimulus 110 2000
 
THD S.P.A. (1)
6,098,629 Submucosal esophageal bulking device 176 1999
 
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (1)
6,610,713 Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation 242 2001
 
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (1)
2002/0055,779 NEURAL PROSTHESIS 128 1997
 
UNIVERSITY OF VIRGINIA (1)
5,690,691 Gastro-intestinal pacemaker having phased multi-point stimulation 390 1996
 
UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (1)
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VENTURE LENDING & LEASING, INC. (1)
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VIDAMED, INC. (1)
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Other [Check patent profile for assignment information] (4)
4,776,349 Tubular device for the treatment of hollow organs with electric current 151 1986
5,292,344 Percutaneously placed electrical gastrointestinal pacemaker stimulatory system, sensing system, and pH monitoring system, with optional delivery port 205 1992
2006/0229,685 Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) 12 2006
2009/0306,739 Methods and apparatus for neuromodulation and physiologic modulation for the treatment of obesity and metabolic and neuropsychiatric disease 6 2009
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
SETPOINT MEDICAL CORPORATION (5)
8,412,338 Devices and methods for optimizing electrode placement for anti-inflamatory stimulation 2 2009
8,886,339 Nerve cuff with pocket for leadless stimulator 0 2010
8,612,002 Neural stimulation devices and systems for treatment of chronic inflammation 1 2010
8,788,034 Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation 0 2012
8,855,767 Neural stimulation devices and systems for treatment of chronic inflammation 0 2013
 
EnteroMedics Inc. (2)
8,538,542 Nerve stimulation and blocking for treatment of gastrointestinal disorders 0 2011
8,538,533 Controlled vagal blockage therapy 0 2011
 
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (1)
8,391,970 Devices and methods for inhibiting granulocyte activation by neural stimulation 2 2008
* Cited By Examiner

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