US Patent No: 8,103,349

Number of patents in Portfolio can not be more than 2000

Neural electrode treatment

ALSO PUBLISHED AS: 20100094375
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Abstract

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An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ENTEROMEDICS INC.ST PAUL, MN33

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Donders, Adrianus P Founex, CH 39 1765
Knudson, Mark B Shoreview, MN 203 7532
Weijand, Koen J Alfas Del Pi, ES 39 1943

Cited Art Landscape

Patent Info (Count) # Cites Year
 
EnteroMedics Inc. (29)
2004/0172,084 Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) 52 2003
2004/0172,085 Nerve stimulation and conduction block therapy 99 2003
2004/0172,086 Nerve conduction block treatment 55 2003
2004/0176,812 Enteric rhythm management 108 2003
7,489,969 Vagal down-regulation obesity treatment 20 2003
7,167,750 Obesity treatment with electrically induced vagal down regulation 122 2004
7,444,183 Intraluminal electrode apparatus and method 47 2004
2005/0070,970 Movement disorder stimulation with neural block 55 2004
2005/0070,974 Obesity and eating disorder stimulation treatment with neural block 59 2004
2005/0038,484 Controlled vagal blockage therapy 113 2004
7,844,338 High frequency obesity treatment 12 2004
2005/0131,485 High frequency vagal blockage therapy 99 2005
7,613,515 High frequency vagal blockage therapy 26 2005
2007/0043,400 Neural electrode treatment 18 2005
7,672,727 Neural electrode treatment 7 2005
7,822,486 Custom sized neural electrodes 19 2005
2007/0135,846 Vagal obesity treatment 26 2007
2007/0135,856 Bulimia treatment 21 2007
2007/0135,857 GI inflammatory disease treatment 22 2007
2007/0135,858 Pancreatitis treatment 21 2007
2007/0142,870 Irritable bowel syndrome treatment 21 2007
7,630,769 GI inflammatory disease treatment 11 2007
7,693,577 Irritable bowel syndrome treatment 8 2007
7,720,540 Pancreatitis treatment 8 2007
7,986,995 Bulimia treatment 5 2007
2008/0021,512 Nerve stimulation and blocking for treatment of gastrointestinal disorders 28 2007
7,729,771 Nerve stimulation and blocking for treatment of gastrointestinal disorders 8 2007
2008/0300,654 IMPLANTABLE THERAPY SYSTEM 26 2007
7,917,226 Antenna arrangements for implantable therapy device 8 2008
 
MEDTRONIC, INC. (26)
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6,216,039 Method and apparatus for treating irregular gastric rhythms 85 1997
5,919,216 System and method for enhancement of glucose production by stimulation of pancreatic beta cells 136 1997
6,093,167 System for pancreatic stimulation and glucose measurement 165 1997
5,967,977 Transesophageal medical lead 70 1997
6,091,992 Method and apparatus for electrical stimulation of the gastrointestinal tract 142 1997
6,104,955 Method and apparatus for electrical stimulation of the gastrointestinal tract 147 1997
6,083,249 Apparatus for sensing and stimulating gastrointestinal tract on-demand 189 1998
5,995,872 Method and apparatus for electrical stimulation of the gastrointestinal tract 179 1998
6,097,984 System and method of stimulation for treating gastro-esophageal reflux disease 162 1998
6,135,978 System for pancreatic stimulation and glucose measurement 294 1999
6,308,105 Medical electrical stimulation system using an electrode assembly having opposing semi-circular arms 60 1999
6,238,423 Apparatus and method for treating chronic constipation 108 1999
6,418,346 Apparatus and method for remote therapy and diagnosis in medical devices via interface systems 243 1999
6,612,983 Pancreatic secretion response to stimulation test protocol 85 2000
6,853,862 Gastroelectric stimulation for influencing pancreatic secretions 107 2000
6,261,280 Method of obtaining a measure of blood glucose 86 2000
6,532,388 Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure 172 2000
6,928,320 Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated 141 2001
2004/0193,229 Gastric electrical stimulation for treatment of gastro-esophageal reflux disease 47 2003
2004/0236,381 Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof 48 2003
2004/0236,382 Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof 47 2003
7,620,454 Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof 10 2003
2005/0075,693 Driver circuitry switchable between energy transfer and telemetry for an implantable medical device 42 2004
2006/0247,737 Alignment indication for transcutaneous energy transfer 26 2005
 
CYBERONICS, INC. (25)
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5,188,104 Treatment of eating disorders by nerve stimulation 424 1991
5,269,303 Treatment of dementia by nerve stimulation 318 1991
5,215,086 Therapeutic treatment of migraine symptoms by stimulation 386 1991
5,251,634 Helical nerve electrode 186 1991
5,299,569 Treatment of neuropsychiatric disorders by nerve stimulation 455 1991
5,335,657 Therapeutic treatment of sleep disorder by nerve stimulation 554 1991
5,231,988 Treatment of endocrine disorders by nerve stimulation 384 1991
5,215,089 Electrode assembly for nerve stimulation 181 1991
5,330,515 Treatment of pain by vagal afferent stimulation 339 1992
5,263,480 Treatment of eating disorders by nerve stimulation 367 1992
5,531,778 Circumneural electrode assembly 211 1994
5,571,150 Treatment of patients in coma by nerve stimulation 319 1994
5,540,730 Treatment of motility disorders by nerve stimulation 463 1995
5,707,400 Treating refractory hypertension by nerve stimulation 421 1995
6,587,719 Treatment of obesity by bilateral vagus nerve stimulation 233 1999
6,473,644 Method to enhance cardiac capillary growth in heart failure patients 311 1999
6,609,025 Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation 214 2001
6,622,038 Treatment of movement disorders by near-diaphragmatic nerve stimulation 140 2001
6,600,956 Circumneural electrode assembly 226 2001
7,299,091 Treatment of obesity by bilateral vagus nerve stimulation 26 2003
7,340,306 Treatment of obesity by sub-diaphragmatic nerve stimulation 21 2003
2007/0027,484 Autonomic nerve stimulation to treat a pancreatic disorder 38 2005
7,620,455 Cranial nerve stimulation to treat eating disorders 14 2005
2007/0100,377 Providing multiple signal modes for a medical device 11 2005
 
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (14)
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
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2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
6,832,114 Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes 169 2001
7,292,890 Vagus nerve stimulation via unidirectional propagation of action potentials 128 2002
2006/0036,293 Methods for treating gastrointestinal disorders 62 2005
 
NEURO AND CARDIAC TECHNOLOGIES, LLC (8)
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2003/0212,440 Method and system for modulating the vagus nerve (10th cranial nerve) using modulated electrical pulses with an inductively coupled stimulation system 147 2002
7,076,307 Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders 69 2004
2005/0137,644 Method and system for vagal blocking and/or vagal stimulation to provide therapy for obesity and other gastrointestinal disorders 53 2005
2005/0143,787 Method and system for providing electrical pulses for neuromodulation of vagus nerve(s), using rechargeable implanted pulse generator 138 2005
2005/0149,146 Method and system to provide therapy for obesity and other medical disorders, by providing electrical pules to symapthetic nerves or vagal nerve(s) with rechargeable implanted pulse generator 99 2005
 
ALLERGAN, INC. (5)
5,437,291 Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction 209 1993
6,312,708 Botulinum toxin implant 159 2000
6,261,572 Method for treating a pancreatic disorder with a neurotoxin 48 2000
2001/0012,828 Intraspinal botulinum toxin for treating pain 22 2001
2004/0086,531 Methods for treating ulcers and gastroesophageal reflux disease 40 2002
 
ADVANCED NEUROMODULATION SYSTEMS, INC. (4)
6,002,964 Epidural nerve root stimulation 138 1998
2003/0181,958 Electric modulation of sympathetic nervous system 147 2002
2006/0190,053 Neural stimulation for treatment of metabolic syndrome and type 2 diabetes 29 2006
2007/0203,521 Nerve stimulation for treatment of obesity, metabolic syndrome, and type 2 diabetes 18 2007
 
BIOCONTROL MEDICAL LTD. (4)
2003/0045,909 Selective nerve fiber stimulation for treating heart conditions 236 2002
2004/0243,182 Treatment of disorders by unidirectional nerve stimulation 108 2004
2005/0267,542 Techniques for applying, configuring, and coordinating nerve fiber stimulation 70 2005
2006/0100,668 Selective nerve fiber stimulation 79 2005
 
CASE WESTERN RESERVE UNIVERSITY (3)
5,199,430 Micturitional assist device 116 1991
6,587,725 Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea 74 2001
7,389,145 Systems and methods for reversibly blocking nerve activity 52 2002
 
CIT GROUP/BUSINESS CREDIT, INC. (3)
4,702,254 Neurocybernetic prosthesis 386 1985
4,867,164 Neurocybernetic prosthesis 357 1987
5,025,807 Neurocybernetic prosthesis 315 1989
 
ENDOVX, INC. (3)
2004/0181,178 Methods and apparatus for treatment of obesity 34 2003
2005/0203,501 Methods and apparatus for treatment of obesity with an ultrasound device movable in two or three axes 41 2005
2006/0015,151 Method of using endoscopic truncal vagoscopy with gastric bypass, gastric banding and other procedures 39 2005
 
BIO CONTROL MEDICAL (B.C.M.) LTD. (2)
6,684,105 Treatment of disorders by unidirectional nerve stimulation 234 2001
7,346,398 Electrode assembly for nerve control 52 2004
 
EMORY UNIVERSITY (2)
7,072,720 Devices and methods for vagus nerve stimulation 72 2002
7,142,910 Methods of indirectly stimulating the vagus nerve with an electrical field 48 2004
 
METACURE LIMITED (2)
6,571,127 Method of increasing the motility of a GI tract 190 2000
6,993,391 Acute and chronic electrical signal therapy for obesity 35 2003
 
TRANSNEURONIX, INC. (2)
5,423,872 Process and device for treating obesity and syndromes related to motor disorders of the stomach of a patient 288 1993
2002/0072,780 Method and apparatus for intentional impairment of gastric motility and /or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity 94 2001
 
BIOENTERIES CORPORATION (1)
5,601,604 Universal gastric band 215 1993
 
Biotronik Mess-und Therapiegeraete GmbH & Co. (1)
6,292,703 Neural electrode arrangement 103 1999
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
6,826,428 Gastrointestinal electrical stimulation 158 2002
 
CARDIOCOMMAND, INC. (1)
6,148,222 Esophageal catheters and method of use 96 1998
 
CEDARS-SINAI MEDICAL CENTER (1)
6,558,708 Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia 52 2000
 
CENTER FOR INNOVATIVE TECHNOLOGY, THE (1)
5,716,385 Crural diaphragm pacemaker and method for treating esophageal reflux disease 82 1996
 
Cerebral Stimulation, Inc. (1)
5,514,175 Auricular electrical stimulator 105 1994
 
CVRX, INC. (1)
2004/0254,616 Stimulus regimens for cardiovascular reflex control 119 2004
 
DILORENZO BIOMEDICAL, LLC (1)
2003/0018,367 Method and apparatus for neuromodulation and phsyiologic modulation for the treatment of metabolic and neuropsychiatric disease 169 2002
 
EURO-CELTIQUE S.A. (1)
5,747,060 Prolonged local anesthesia with colchicine 107 1996
 
FLINT HILLS SCIENTIFIC, LLC (1)
6,341,236 Vagal nerve stimulation techniques for treatment of epileptic seizures 360 1999
 
FORSCHUNGSZENTRUM JULICH GMBH (1)
2006/0212,089 Device for the desynchronization of neuronal brain activity 27 2004
 
HITACHI GLOBAL STORAGE TECHNOLOGIES JAPAN, LTD. (1)
6,111,715 Storage apparatus using a magnetoresistive head that employs a sense current selected from plural predetermined sense currents 24 1998
 
INAMED DEVELOPMENT COMPANY (1)
5,226,429 Laparoscopic gastric band and method 351 1991
 
INNERCOOL THERAPIES, INC., A DELAWARE CORPORATION (1)
6,364,899 Heat pipe nerve cooler 98 1999
 
INTRAPACE, INC. (1)
7,054,690 Gastrointestinal stimulation device 60 2003
 
KNIGHT, MARTHA (1)
5,620,955 Bombesin receptor antagonists and uses thereof 29 1993
 
KOSAN BIOSCIENCES, INC. (1)
2002/0094,962 Motilide compounds 23 2001
 
LEPTOS BIODMEDICAL, INC. (1)
2003/0181,959 Wireless electric modulation of sympathetic nervous system 74 2002
 
MEDERI THERAPEUTICS, INC. (1)
6,405,732 Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors 191 1999
 
MEDICAL UNIVERSITY OF SOUTH CAROLINA (1)
5,830,434 Methods of treating non-insulin dependent diabetes mellitus with pancreatic polypeptide 22 1997
 
MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. (1)
2006/0041,277 Methods and apparatus for renal neuromodulation 66 2005
 
MEDTRONIC TRANSNEURONIX, INC. (1)
6,895,278 Gastric stimulator apparatus and method for use 93 1999
 
Michael J. Jaro (1)
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Michigan Instruments, Inc. (1)
4,198,963 Cardiopulmonary resuscitator, defibrillator and monitor 105 1978
 
NDI MEDICAL, LLC (1)
2006/0030,919 Devices, systems, and methods employing a molded nerve cuff electrode 46 2005
 
Neuro and Cardial Technologies, LLC (1)
7,444,184 Method and system for providing therapy for bulimia/eating disorders by providing electrical pulses to vagus nerve(s) 19 2005
 
NEUROPACE, INC. (1)
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PALO ALTO INVESTORS (1)
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SECOND SIGHT MEDICAL PRODUCTS, INC. (1)
2003/0195,601 High-density array of micro-machined electrodes for neural stimulation 38 2002
 
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UNIVERSITY OF VIRGINIA (1)
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Other [Check patent profile for assignment information] (4)
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2009/0306,739 Methods and apparatus for neuromodulation and physiologic modulation for the treatment of obesity and metabolic and neuropsychiatric disease 4 2009

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
EnteroMedics Inc. (2)
8,538,542 Nerve stimulation and blocking for treatment of gastrointestinal disorders 0 2011
8,538,533 Controlled vagal blockage therapy 0 2011
 
SETPOINT MEDICAL CORPORATION (2)
8,412,338 Devices and methods for optimizing electrode placement for anti-inflamatory stimulation 1 2009
8,612,002 Neural stimulation devices and systems for treatment of chronic inflammation 0 2010
 
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (1)
8,391,970 Devices and methods for inhibiting granulocyte activation by neural stimulation 1 2008
 
Other [Check patent profile for assignment information] (1)
8,788,034 Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation 0 2012

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