Phosphatases involved in the regulation of cardiomyocyte differentiation
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United States of America Patent
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Jan 31, 2012
Grant Date -
Nov 26, 2009
app pub date -
Apr 12, 2007
filing date -
Apr 14, 2006
priority date (Note) -
Expired
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Abstract
An object of the invention is to provide a dephosphorylation enzyme that regulates cardiomyocyte differentiation, dominant negative enzyme thereof, a gene encoding the enzyme protein and use thereof. A protein or the like consisting of any one of the following amino acid sequences (A) to (C) is used: (A) the amino acid sequence of SEQ ID NO:2; (B) an amino acid sequence wherein one or several amino acids except for cysteine at position 138 are deleted, substituted or added in the amino acid sequence of SEQ ID NO:2, wherein a protein consisting of the amino acid sequence has a dual specificity phosphatase activity; and (C) an amino acid sequence having at least 60% or more homology to the amino acid sequence of SEQ ID NO:2 and having cysteine at position 138, wherein a protein consisting of the amino acid sequence has a dual specificity phosphatase activity.
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