Method and apparatus for imaging target components in a biological sample using permanent magnets

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United States of America Patent

PATENT NO 8110101
APP PUB NO 20090061476A1
SERIAL NO

11897471

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Abstract

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A system for enumeration of cells in fluids by image cytometry is described for assessment of target populations such as leukocyte subsets in different bodily fluids or bacterial contamination in environmental samples, food products and bodily fluids. Briefly, all cells in a biological sample are fluorescently labeled, but only the target cells are also magnetically labeled. A small, permanent magnet is inserted directly into the chamber containing the labeled sample. The magnets are coated with PDMS silicone rubber to provide a smooth and even surface which allows imaging on a single focal plane. The cells are illuminated and the images of the fluorescent light emitted by the target cells are captured by a CCD camera. Image analysis performed with a novel algorithm provides a count of the cells on the surface that can be related to the target cell concentration of the original sample.

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Patent Owner(s)

Patent OwnerAddress
MENARINI SILICON BIOSYSTEMS S P A40013 CASTEL MAGGIORE (BO)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Terstappen, Leon W M M Huntingdon Valley, US 41 2272
Tibbe, Arjan G J Deventer, NL 9 129

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