Degradation and detection of TSE infectivity
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United States of America Patent
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Feb 7, 2012
Grant Date -
Jul 24, 2008
app pub date -
Oct 11, 2007
filing date -
Jan 8, 2001
priority date (Note) -
Expired
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Abstract
A transmissible spongiform encephalopathy (TSE) agent is inactivated by exposing the TSE agent to a thermostable proteolytic enzyme at elevated temperature and at acid or alkaline pH. Following this step, or separately, presence of TSE infectivity is detected by detection of dimers of prion protein.
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