US Patent No: 8,114,437
Number of patents in Portfolio can not be more than 2000
Solvent/polymer solutions as suspension vehicles
Stats
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Feb 14, 2012
Issued date -
Feb 3, 2006
filing date -
11/347,562
serial no -
In Force
status
Importance
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Abstract
A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
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First Claim
Related Publications
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 5,728,396 Sustained delivery of leuprolide using an implantable system | 159 | 1997 | |
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| 6,217,906 Self adjustable exit port | 17 | 1999 | |
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| 6,508,808 Valve for osmotic devices | 32 | 2000 | |
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| 7,163,688 Osmotic implant with membrane and membrane retention means | 25 | 2002 | |
| 6,840,931 Osmotic delivery system flow modulator apparatus and method | 17 | 2002 | |
| 7,014,636 Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel | 30 | 2002 | |
| 2003/0108,609 Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles | 9 | 2002 | |
| 7,074,423 Osmotic delivery system with early zero order push power engine | 25 | 2003 | |
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| 2005/0175,701 Capillary moderator for osmotic delivery system | 25 | 2005 | |
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| 5,312,389 Osmotically driven syringe with programmable agent delivery | 49 | 1992 | |
| 5,904,935 Peptide/protein suspending formulations | 29 | 1995 | |
| 5,932,547 Non-aqueous polar aprotic peptide formulations | 38 | 1997 | |
| 6,130,200 Gel composition and methods | 59 | 1997 | |
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| 6,673,767 Gel composition and methods | 33 | 2000 | |
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| 2004/0024,069 Injectable depot compositions and uses thereof | 11 | 2002 | |
| 2004/0001,889 Short duration depot formulations | 15 | 2003 | |
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| 5,234,693 Delivery device with a protective sleeve | 82 | 1992 | |
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| 6,447,522 Implant delivery system | 80 | 2001 | |
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| 5,836,935 Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body | 145 | 1997 | |
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| 5,511,355 Construction element | 30 | 1992 | |
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| 2003/0059,376 Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same | 13 | 2002 | |
| 2003/0044,467 Gel composition and methods | 14 | 2002 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 3.5 Year Payment | $1600.00 | $800.00 | $400.00 | Aug 14, 2015 |
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Aug 14, 2019 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Aug 14, 2023 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 3.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |