Products for altering IL-33 activity and methods thereof
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United States of America Patent
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Feb 21, 2012
Grant Date -
Oct 14, 2010
app pub date -
Apr 28, 2008
filing date -
Apr 26, 2007
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Products for altering IL-33 activity including antibodies that specifically bind to an epitope with the polypeptide sequence of IL-33 such as antibodies that specifically bind to a protease cleavage region of IL-33 comprising the amino acid sequence of SEQ ID No. 17, or SEQ ID NO. 16, or SEQ ID NO. 10; isolated IL-33 polypeptide(s); and compositions comprising a soluble IL-33 receptor linked to an enzyme capable of cleaving IL-33 or an antibody that binds to IL-33 linked to an enzyme capable of cleaving IL-33. The invention also relates to methods of altering IL-33 activity using the products described herein.
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