Renal carcinoma cell line and uses thereof
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United States of America Patent
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Mar 6, 2012
Grant Date -
May 28, 2009
app pub date -
Oct 20, 2006
filing date -
Oct 21, 2005
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Abstract
The present invention relates to a renal carcinoma cell line capable of activating the immune system in an antigen-specific manner. According to a further aspect, the invention also includes derivatives of the cell line that maintain said activation capacity. The invention also comprises a method for targeting and activating immune system cells against cells of clear cell renal carcinoma. Said method comprises the co-incubation of isolated immune system cells (dendritic cells, CD4+, CD8+ lymphocytes etc.) with cells of the RCC BA85#21 line in accordance with the invention in a suitable culture medium, for a time sufficient to obtain antigen specific cells.
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