Oligomeric compounds and compositions for the use in modulation of microRNAs

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United States of America Patent

PATENT NO 8129515
APP PUB NO 20090221685A1
SERIAL NO

12161286

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhibitory activity, and further exhibit improved therapeutic index. Further provided are methods for selectively modulating miRNA activity in a cell.

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Patent Owner(s)

Patent OwnerAddress
IONIS PHARMACEUTICALS INC2855 GAZELLE COURT CARLSBAD CA 92010

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bhat, Balkrishen Carlsbad, US 173 7460
Esau, Christine La Jolla, US 42 890
Kinberger, Garth A San Diego, US 24 357
Swayze, Eric E Carlsbad, US 355 10308

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