Method for preparing a mixed solvate of olanzapine
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United States of America Patent
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Mar 6, 2012
Grant Date -
Dec 24, 2009
app pub date -
Dec 20, 2006
filing date -
Jan 5, 2006
priority date (Note) -
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Abstract
An improved method is provided for preparing a mixed solvate of olanzapine/water/tetrahydrofuran in a proportion of 1:1:1/2. Said improvement is characterised in that said mixed solvate is basically prepared by means of methylation of the N-desmethylolanzapine with dimethyl sulphate, using tetrahydrofuran and water as solvents.
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