Methods and apparatus for monopolar renal neuromodulation
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United States of America Patent
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Mar 6, 2012
Grant Date -
Nov 23, 2006
app pub date -
Apr 13, 2006
filing date -
Apr 8, 2002
priority date (Note) -
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Abstract
Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, monopolar neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such monopolar neuromodulation is performed bilaterally.
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