Chemically modified nucleoside 5′-triphosphates for thermally initiated amplification of nucleic acid
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United States of America Patent
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Mar 13, 2012
Grant Date -
Jan 7, 2010
app pub date -
May 21, 2009
filing date -
May 27, 2008
priority date (Note) -
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Abstract
Provided herein are methods and compositions for nucleic acid replication. These methods involve the use of 3′-substituted nucleoside 5′-triphosphates or 3′-substituted terminated primers in nucleic acid replication reactions. In certain aspects, the methods are accomplished by use of 3′-substituted NTPs and/or 3′-substituted terminated primers which provide utility in nucleic acid replication. In preferred embodiments, the NTPs and/or primers are substituted at the 3′-position with particular heat labile chemical groups such as ethers, esters or carbonate esters.
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International Classification(s)
- C07H:SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTI....
- C12Q:MEASURING OR TESTING PROCESSES INVOLVING ENZYMES O....
- C07G:COMPOUNDS OF UNKNOWN CONSTITUTION
- C12P:FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESI....
- G01N:INVESTIGATING OR ANALYSING MATERIALS BY DETERMININ....
- B01L:CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENE....
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