US Patent No: 8,133,865
Number of patents in Portfolio can not be more than 2000
von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage
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Mar 13, 2012
Issued date -
Dec 27, 2007
filing date -
12/006,059
serial no -
In Force
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Abstract
The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
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First Claim
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 5,629,384 Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces | 80 | 1994 | |
| 5,932,462 Multiarmed, monofunctional, polymer for coupling to molecules and surfaces | 317 | 1995 | |
| 6,362,254 Poly(ethylene glycol) derivatives with proximal reactive groups | 74 | 1999 | |
| 6,514,491 Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) | 8 | 2001 | |
| 7,199,223 Polymer-factor VIII moiety conjugates | 31 | 2004 | |
| 7,060,259 Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) | 6 | 2005 | |
| 2006/0293,499 Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates | 6 | 2006 | |
| 2008/0058,504 Polymer-factor VIII moiety conjugates | 8 | 2007 | |
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| 5,122,614 Active carbonates of polyalkylene oxides for modification of polypeptides | 283 | 1990 | |
| 5,298,643 Aryl imidate activated polyalkylene oxides | 57 | 1992 | |
| 5,621,039 Factor IX- polymeric conjugates | 62 | 1993 | |
| 5,637,749 Aryl imidate activated polyalkylene oxides | 78 | 1995 | |
| 5,969,040 Factor IX -- polymeric conjugates | 77 | 1996 | |
| 6,566,506 Non-antigenic branched polymer conjugates | 13 | 2000 | |
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| 2007/0027,073 Long-acting derivatives of pyy agonists | 9 | 2004 | |
| 2006/0171,920 Reversible pegylated drugs | 14 | 2005 | |
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| 7,884,075 Polymer-factor VIII-von Willebrand factor-conjugates | 3 | 2005 | |
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| 4,510,233 Antistatic agent containing silver halide photographic light-sensitive materials | 11 | 1983 | |
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| 6,037,452 Poly(alkylene oxide)-Factor VIII or Factor IX conjugate | 61 | 1992 | |
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| 7,125,843 Glycoconjugates including more than one peptide | 28 | 2003 | |
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| 6,048,720 Conjugates of a polypeptide and a biocompatible polymer | 48 | 1998 | |
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| 5,612,039 Dietary supplement | 37 | 1995 | |
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| 2005/0079,155 Generating protein pro-drugs using reversible PPG linkages | 6 | 2004 | |
Patent Citation Ranking
Maintenance Fees
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