US Patent No: 8,133,865

Number of patents in Portfolio can not be more than 2000

von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage

ALSO PUBLISHED AS: 20080234193

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.

Loading the Abstract Image... loading....

First Claim

See full text

all claims..

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
BAXTER HEALTHCARE S.A.DEERFIELD, IL593
BAXTER INTERNATIONAL INC.DEERFIELD, IL997
NEKTAR THERAPEUTICSSAN CARLOS, CA262

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bossard, Mary J Madison, AL 86 138
Fang, Zhihao Madison, AL 56 144
Gritsch, Herbert Vienna, AT 15 51
Mitchell, Stacy Madison, AL 11 18
Scheiflinger, Friedrich Vienna, AT 97 134
Siekmann, Juergen Vienna, AT 77 89
Stephenson, Gayle Madison, AL 21 13
Turecek, Peter Vienna, AT 174 488
Varadi, Katalin Vienna, AT 28 44
Zappe, Harold Harvest, AL 17 5
Zhang, Ping Peoria, IL 142 191

Cited Art Landscape

Patent Info (Count) # Cites Year
 
NEKTAR THERAPEUTICS (8)
5,629,384 Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces 115 1994
5,932,462 Multiarmed, monofunctional, polymer for coupling to molecules and surfaces 403 1995
6,362,254 Poly(ethylene glycol) derivatives with proximal reactive groups 114 1999
6,514,491 Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) 13 2001
* 7,199,223 Polymer-factor VIII moiety conjugates 54 2004
7,060,259 Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) 9 2005
2006/0293,499 Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates 12 2006
2008/0058,504 Polymer-factor VIII moiety conjugates 11 2007
 
ENZON, INC. (6)
* 5,122,614 Active carbonates of polyalkylene oxides for modification of polypeptides 321 1990
* 5,298,643 Aryl imidate activated polyalkylene oxides 69 1992
* 5,621,039 Factor IX- polymeric conjugates 84 1993
5,637,749 Aryl imidate activated polyalkylene oxides 88 1995
5,969,040 Factor IX -- polymeric conjugates 97 1996
6,566,506 Non-antigenic branched polymer conjugates 19 2000
 
YEDA RESEARCH AND DEVELOPMENT CO. LTD. (2)
2007/0027,073 Long-acting derivatives of pyy agonists 13 2004
2006/0171,920 Reversible pegylated drugs 35 2005
 
BAXTER INTERNATIONAL INC. (1)
* 7,884,075 Polymer-factor VIII-von Willebrand factor-conjugates 4 2005
 
FUJI PHOTO FILM CO., LTD. (1)
4,510,233 Antistatic agent containing silver halide photographic light-sensitive materials 15 1983
 
GRIFOLS INC. (1)
* 6,037,452 Poly(alkylene oxide)-Factor VIII or Factor IX conjugate 84 1992
 
NOVO NORDISK A/S (1)
7,125,843 Glycoconjugates including more than one peptide 43 2003
 
PHARMACIA & UPJOHN (1)
6,048,720 Conjugates of a polypeptide and a biocompatible polymer 73 1998
 
POLICAPPELLI, NINI E. (1)
5,612,039 Dietary supplement 38 1995
 
XENCOR, INC. (1)
2005/0079,155 Generating protein pro-drugs using reversible PPG linkages 11 2004
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

  • No Forward Cites to Display

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 Sep 13, 2015
7.5 Year Payment $3600.00 $1800.00 $900.00 Sep 13, 2019
11.5 Year Payment $7400.00 $3700.00 $1850.00 Sep 13, 2023
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00