US Patent No: 8,133,865

Number of patents in Portfolio can not be more than 2000

von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage

Stats

ALSO PUBLISHED AS: 20080234193
See full text
ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.

Loading the Abstract Image... loading....

First Claim

See full text

all claims..

Related Publications

Loading Related Publications... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
BAXTER HEALTHCARE S.A.DEERFIELD, IL546
BAXTER INTERNATIONAL INC.DEERFIELD, IL1691
NEKTAR THERAPEUTICSSAN CARLOS, CA231

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bossard, Mary J Madison, AL 83 106
Fang, Zhihao Madison, AL 55 116
Gritsch, Herbert Vienna, AT 15 47
Mitchell, Stacy Madison, AL 11 12
Scheiflinger, Friedrich Vienna, AT 90 114
Siekmann, Juergen Vienna, AT 74 71
Stephenson, Gayle Madison, AL 20 9
Turecek, Peter Vienna, AT 160 426
Varadi, Katalin Vienna, AT 25 41
Zappe, Harold Harvest, AL 16 4
Zhang, Ping Peoria, IL 127 146

Cited Art Landscape

Patent Info (Count) # Cites Year
 
NEKTAR THERAPEUTICS (8)
5,629,384 Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces 97 1994
5,932,462 Multiarmed, monofunctional, polymer for coupling to molecules and surfaces 364 1995
6,362,254 Poly(ethylene glycol) derivatives with proximal reactive groups 94 1999
6,514,491 Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) 10 2001
7,199,223 Polymer-factor VIII moiety conjugates 44 2004
7,060,259 Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) 8 2005
2006/0293,499 Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates 9 2006
2008/0058,504 Polymer-factor VIII moiety conjugates 10 2007
 
ENZON, INC. (6)
5,122,614 Active carbonates of polyalkylene oxides for modification of polypeptides 300 1990
5,298,643 Aryl imidate activated polyalkylene oxides 67 1992
5,621,039 Factor IX- polymeric conjugates 71 1993
5,637,749 Aryl imidate activated polyalkylene oxides 87 1995
5,969,040 Factor IX -- polymeric conjugates 87 1996
6,566,506 Non-antigenic branched polymer conjugates 18 2000
 
YEDA RESEARCH AND DEVELOPMENT CO. LTD. (2)
2007/0027,073 Long-acting derivatives of pyy agonists 11 2004
2006/0171,920 Reversible pegylated drugs 26 2005
 
BAXTER INTERNATIONAL INC. (1)
7,884,075 Polymer-factor VIII-von Willebrand factor-conjugates 4 2005
 
FUJI PHOTO FILM CO., LTD. (1)
4,510,233 Antistatic agent containing silver halide photographic light-sensitive materials 13 1983
 
GRIFOLS INC. (1)
6,037,452 Poly(alkylene oxide)-Factor VIII or Factor IX conjugate 73 1992
 
NOVO NORDISK A/S (1)
7,125,843 Glycoconjugates including more than one peptide 35 2003
 
PHARMACIA & UPJOHN (1)
6,048,720 Conjugates of a polypeptide and a biocompatible polymer 62 1998
 
POLICAPPELLI, NINI E. (1)
5,612,039 Dietary supplement 38 1995
 
XENCOR, INC. (1)
2005/0079,155 Generating protein pro-drugs using reversible PPG linkages 9 2004

Patent Citation Ranking

Forward Cite Landscape

  • No Forward Cites to Display

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 Sep 13, 2015
7.5 Year Payment $3600.00 $1800.00 $900.00 Sep 13, 2019
11.5 Year Payment $7400.00 $3700.00 $1850.00 Sep 13, 2023
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00