von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage

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United States of America Patent

PATENT NO 8133865
APP PUB NO 20080234193A1
SERIAL NO

12006059

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Abstract

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The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BAXALTA GMBHOPFIKON, CH330
BAXALTA INCORPORATEDBANNOCKBURN, IL331
NEKTAR THERAPEUTICSSAN CARLOS, CA356

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bossard, Mary J Madison, US 62 405
Fang, Zhihao Madison, US 37 293
Gritsch, Herbert Vienna, AT 10 88
Mitchell, Stacy Madison, US 6 99
Scheiflinger, Friedrich Vienna, AT 76 227
Siekmann, Juergen Vienna, AT 55 163
Stephenson, Gayle Decatur, US 15 63
Turecek, Peter Klosterneuburg, AT 132 711
Varadi, Katalin Vienna, AT 20 80
Zappe, Harold Harvest, US 13 35
Zhang, Ping Madison, US 127 396

Cited Art Landscape

Patent Info (Count) # Cites Year
 
PHARMACIA & UPJOHN (1)
6048720 Conjugates of a polypeptide and a biocompatible polymer 101 1998
 
POLICAPPELLI, NINI E. (1)
5612039 Dietary supplement 39 1995
 
Enzon, Inc. (6)
* 5122614 Active carbonates of polyalkylene oxides for modification of polypeptides 382 1990
* 5298643 Aryl imidate activated polyalkylene oxides 82 1992
* 5621039 Factor IX- polymeric conjugates 104 1993
5637749 Aryl imidate activated polyalkylene oxides 103 1995
5969040 Factor IX -- polymeric conjugates 118 1996
6566506 Non-antigenic branched polymer conjugates 27 2000
 
NEKTAR THERAPEUTICS (8)
5629384 Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces 164 1994
5932462 Multiarmed, monofunctional, polymer for coupling to molecules and surfaces 526 1995
6362254 Poly(ethylene glycol) derivatives with proximal reactive groups 147 1999
6514491 Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) 16 2001
* 7199223 Polymer-factor VIII moiety conjugates 78 2004
7060259 Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) 11 2005
2006/0293,499 Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates 20 2006
2008/0058,504 Polymer-factor VIII moiety conjugates 12 2007
 
XENCOR, INC. (1)
2005/0079,155 Generating protein pro-drugs using reversible PPG linkages 15 2004
 
NOVO NORDISK A/S (1)
7125843 Glycoconjugates including more than one peptide 60 2003
 
FUJI PHOTO FILM CO., LTD. (1)
4510233 Antistatic agent containing silver halide photographic light-sensitive materials 18 1983
 
YEDA RESEARCH AND DEVELOPMENT CO. LTD. (2)
2007/0027,073 Long-acting derivatives of pyy agonists 16 2004
2006/0171,920 Reversible pegylated drugs 73 2005
 
GRIFOLS INC. (1)
* 6037452 Poly(alkylene oxide)-Factor VIII or Factor IX conjugate 105 1992
 
BAXALTA INCORPORATED (1)
* 7884075 Polymer-factor VIII-von Willebrand factor-conjugates 6 2005
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
BAXTER INTERNATIONAL INC. (1)
* 2010/0121,028 Hydrolysable Polymeric FMOC- Linker 0 2010
* Cited By Examiner

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