US Patent No: 8,133,968
Number of patents in Portfolio can not be more than 2000
Poly(orthoester) polymers, and methods of making and using same
Stats
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Mar 13, 2012
Issued date -
Dec 14, 2010
filing date -
12/968,004
serial no -
In Force
status
Importance
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Abstract
Poly(orthoester) polymers, and methods of making and using such poly(orthoester) polymers are provided. The poly(orthoester) polymers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the poly(orthoester) polymers are biodegradable.
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First Claim
Related Publications
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 6,096,344 Bioerodible porous compositions | 46 | 1997 | |
| 5,968,543 Polymers with controlled physical state and bioerodibility | 43 | 1997 | |
| 5,939,453 PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers | 55 | 1998 | |
| 6,613,355 Semi-solid delivery vehicle and pharmaceutical compositions | 21 | 2001 | |
| 2002/0176,844 Bioerodible polyorthoesters containing hydrogen bonding groups | 9 | 2001 | |
| 6,524,606 Bioerodible polyorthoesters containing amine groups | 14 | 2001 | |
| 2003/0152,630 PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers | 6 | 2002 | |
| 6,667,371 Block copolymers based on poly(ortho esters) containing amine groups | 15 | 2002 | |
| 6,863,782 Method of preparing di(ketene acetals) | 2 | 2002 | |
| 7,045,589 Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them | 2 | 2002 | |
| 6,822,000 Bioerodible poly (orthoesters) from dioxolane-based diketene acetals | 6 | 2002 | |
| 6,790,458 Pharmaceutical compositions using semi-solid delivery vehicle | 6 | 2003 | |
| 6,946,145 Block copolymers based on poly(ortho esters) containing amine groups | 3 | 2003 | |
| 6,861,068 Pharmaceutical compositions using semi-solid delivery vehicle | 23 | 2004 | |
| 2005/0042,194 Semi-solid delivery vehicle and pharmaceutical compositions | 12 | 2004 | |
| 7,163,694 Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them | 2 | 2006 | |
| 7,456,213 PEG-poly(ortho ester) graft copolymers and pharmaceutical compositions | 1 | 2006 | |
| 2006/0235,083 PEG-poly(ortho ester) graft copolymers and pharmaceutical compositions | 2 | 2006 | |
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| 2004/0033,251 Active agent delivery system including a polyurethane, medical device, and method | 10 | 2003 | |
| 2004/0039,437 Medical device exhibiting improved adhesion between polymeric coating and substrate | 25 | 2003 | |
| 2004/0047,911 Active agent delivery system including a poly(ethylene-co-(meth)Acrylate), medical device, and method | 17 | 2003 | |
| 2004/0086,569 Active agent delivery systems, medical devices, and methods | 17 | 2003 | |
| 2004/0115,273 Active agent delivery system including a hydrophobic cellulose derivative, medical device, and method | 13 | 2003 | |
| 2004/0127,978 Active agent delivery system including a hydrophilic polymer, medical device, and method | 14 | 2003 | |
| 2005/0064,005 Active agent delivery systems including a miscible polymer blend, medical devices, and methods | 16 | 2004 | |
| 2005/0064,038 Active agent delivery systems including a single layer of a miscible polymer blend, medical devices, and methods | 13 | 2004 | |
| 7,741,375 Polyketal polymers, and methods of making and using same | 1 | 2007 | |
| 7,875,697 Poly(orthoester) polymers, and methods of making and using same | 2 | 2007 | |
| 2008/0033,140 Poly(orthoester) polymers, and methods of making and using same | 1 | 2007 | |
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| 4,489,056 Acid anhydrides as rate controlling agent for the erosion of polymers which latter polymers have beneficial substances dispersed throughout their matrix or where the polymer matrix surrounds the beneficial substance | 51 | 1982 | |
| 4,639,366 Polymers containing pendant acid functionalities and labile backbone bonds | 21 | 1984 | |
| 4,549,010 Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal | 33 | 1984 | |
| 4,765,973 Polymers containing pendant acid functionalities and labile backbone bonds | 18 | 1986 | |
| 4,780,319 Organic acids as catalysts for the erosion of polymers | 17 | 1987 | |
| 4,767,627 Drug delivery device which can be retained in the stomach for a controlled period of time | 51 | 1987 | |
| 4,758,436 Drug delivery device which can be retained in the stomach for a controlled period of time | 16 | 1987 | |
| 5,211,951 Process for the manufacture of bioerodible poly (orthoester)s and polyacetals | 12 | 1991 | |
| 5,254,345 Poly(orthocarbonate acetal) bioerodible polymers | 3 | 1991 | |
| 5,837,228 Bioerodible implants | 14 | 1992 | |
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| 5,747,060 Prolonged local anesthesia with colchicine | 71 | 1996 | |
| 5,942,241 Formulations and methods for providing prolonged local anesthesia | 76 | 1997 | |
| 6,248,345 Prolonged anesthesia in joints and body spaces | 40 | 1998 | |
| 6,514,516 Formulations and methods for providing prolonged local anesthesia | 13 | 1999 | |
| 6,524,607 Formulations and methods for providing prolonged local anesthesia | 36 | 2000 | |
| 6,534,081 Prolonged anesthesia in joints and body spaces | 30 | 2001 | |
| 6,699,908 Methods for providing safe local anesthesia | 12 | 2001 | |
| 6,921,541 Formulations and methods for providing prolonged local anesthesia | 27 | 2002 | |
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| 4,957,998 Polymers containing acetal, carboxy-acetal, ortho ester and carboxyortho ester linkages | 21 | 1988 | |
| 4,946,931 Polymers containing carboxy-ortho ester and ortho ester linkages | 32 | 1989 | |
| 5,013,821 Ortho and thio-ortho ester polymer | 8 | 1989 | |
| 5,030,457 Bioerodible polymers useful for the controlled release of therapeutic agents | 22 | 1989 | |
| 5,336,505 Bioerodible polymers useful for the controlled release of therapeutic agents | 25 | 1991 | |
| 5,461,140 Bioerodible polymers for solid controlled release pharmaceutical compositions | 22 | 1993 | |
| 5,824,343 Bioerodible polymers, compositions and therapeutic method | 14 | 1994 | |
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| 5,747,058 High viscosity liquid controlled delivery system | 113 | 1995 | |
| 5,968,542 High viscosity liquid controlled delivery system as a device | 55 | 1997 | |
| 6,413,536 High viscosity liquid controlled delivery system and medical or surgical device | 46 | 1999 | |
| 7,833,543 High viscosity liquid controlled delivery system and medical or surgical device | 12 | 2002 | |
| 2004/0109,893 Sustained release dosage forms of anesthetics for pain management | 18 | 2003 | |
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| 4,304,767 Polymers of di- (and higher functionality) ketene acetals and polyols | 102 | 1980 | |
| 4,513,143 Preparation of ketene acetals | 17 | 1982 | |
| 4,532,335 Preparation of ketene acetals by rearrangement of allyl and substituted allyl acetals | 19 | 1983 | |
| 4,764,364 Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product | 29 | 1986 | |
| 4,855,132 Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product | 41 | 1988 | |
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| 5,618,563 Biodegradable polymer matrices for sustained delivery of local anesthetic agents | 79 | 1993 | |
| 5,700,485 Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid | 52 | 1995 | |
| 6,214,387 Biodegradable polymer matrices for sustained delivery of local anesthetic agents | 15 | 1997 | |
| 6,238,702 High load formulations and methods for providing prolonged local anesthesia | 34 | 1999 | |
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| 5,587,507 Synthesis of tyrosine derived diphenol monomers | 76 | 1995 | |
| 6,120,491 Biodegradable, anionic polymers derived from the amino acid L-tyrosine | 141 | 1998 | |
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| 4,735,804 Drug delivery device which can be retained in the stomach for a controlled period of time | 11 | 1987 | |
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| 7,288,609 Coatings for drug delivery devices based on poly (orthoesters) | 7 | 2003 | |
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| 4,186,185 Compositions comprising arylene substituted poly(orthoesters) containing useful agents | 8 | 1978 | |
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| 5,374,681 Polyacetals based on divinyl ethers, dihydroxy compounds and monohydroxy compounds | 14 | 1994 | |
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| 2005/0165,199 Binders containing ortho ester groups | 1 | 2005 | |
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| 6,602,975 Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers | 24 | 2001 | |
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| 2008/0286,326 Medical devices having antifouling character | 4 | 2007 | |
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| 2005/0025,834 Bioerodible sustained release drug delivery systems | 3 | 2004 | |
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| 6,133,402 Polycarbonates made using high activity catalysts | 11 | 1999 | |
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| 2005/0209,433 Orthoester-protected polyols for low VOC coatings | 1 | 2005 | |
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| 7,319,132 Polymer compounds containing oxetane and maleimide functionality | 2 | 2005 | |
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| 4,638,045 Non-peptide polyamino acid bioerodible polymers | 83 | 1985 | |
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| 4,898,928 Polyacetal and polyketal hydrogels formed from acetals or ketals and polyols | 10 | 1988 | |
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| 6,793,938 Biodegradable compositions for the controlled release of encapsulated substances | 8 | 2001 | |
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| 2004/0077,486 Esterfication catalyst, polyester process and polyester article | 9 | 2003 | |
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| 7,649,023 Biodegradable block copolymeric compositions for drug delivery | 1 | 2002 | |
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| 6,933,328 Composition of crosslinkable prepolymers for biodegradable implants | 16 | 2001 | |
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| 5,108,755 Biodegradable composites for internal medical use | 157 | 1989 | |
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| 5,919,473 Methods and devices for delivering opioid analgesics to wounds via a subdermal implant | 54 | 1997 | |
| 2002/0161,135 Coating composition comprising a bicyclo- or spiro-orthoester functional compound | 4 | 2001 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
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| 3.5 Year Payment | $1600.00 | $800.00 | $400.00 | Sep 13, 2015 |
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Sep 13, 2019 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Sep 13, 2023 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 3.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |