Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
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United States of America Patent
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Mar 13, 2012
Grant Date -
Sep 25, 2008
app pub date -
Mar 24, 2008
filing date -
May 5, 2004
priority date (Note) -
Expired
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Abstract
Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
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