Acoustically mediated fluid transfer methods and uses thereof
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United States of America Patent
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Mar 20, 2012
Grant Date -
May 1, 2008
app pub date -
Dec 26, 2007
filing date -
Dec 12, 2000
priority date (Note) -
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Abstract
Invention methods employ the use of acoustic waves to transfer small amounts of fluid in a non-contact manner. In invention methods, acoustic waves are propagated through a separated pool of a source fluid in such a manner that causes the ejection of a single micro-droplet from the surface of the pool. The droplet is ejected towards a target with sufficient force to provide for contact of the droplet with the target. Because the fluid is not contacted by any fluid transfer device such as a pipette, the opportunities for contamination are minimized. Invention methods may be employed to transfer fluids from an array of source sites to an array of target sites, thereby enabling the precision automation of a wide variety of procedures including screening, and synthesis procedures commonly used in biotechnology.
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