Elimination of heterogeneous or mixed cell population in tumors
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United States of America Patent
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Mar 20, 2012
Grant Date -
Mar 19, 2009
app pub date -
Aug 5, 2008
filing date -
Apr 15, 2005
priority date (Note) -
Expired
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Abstract
Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor.
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