Hydroxyphenyl cross-linked macromolecular network and applications thereof
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United States of America Patent
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Mar 20, 2012
Grant Date -
Jun 4, 2009
app pub date -
Jan 29, 2009
filing date -
Jan 10, 2003
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Abstract
A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
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