Antibody-drug conjugates and methods

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United States of America Patent

PATENT NO 8142784
APP PUB NO 20090202536A1
SERIAL NO

12326721

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Abstract

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The present invention relates to antibody-drug conjugate compounds of Formula I:

description='In-line Formulae' end='lead'Ab-(L-D)p  Idescription='In-line Formulae' end='tail'

    where one or more maytansinoid drug moieties (D) are covalently linked by L to an antibody (Ab) which binds to an ErbB receptor, or which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be used in methods of diagnosis or treatment of cancer, and other diseases and disorders.

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Patent Owner(s)

Patent OwnerAddress
GENENTECH INCCALIFORNIA USA CALIFORNIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ebens,, Jr Allen J San Carlos, US 22 618
Jacobson, Frederic S Berkeley, US 4 455
Polakis, Paul Burlingame, US 164 3610
Schwall, Ralph H Pacifica, US 31 916
Sliwkowski, Mark X San Carlos, US 75 3272
Spencer, Susan D Tiburon, US 70 2832

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