Toxicity typing using liver stem cells
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United States of America Patent
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Mar 27, 2012
Grant Date -
May 17, 2007
app pub date -
Jun 1, 2006
filing date -
Jun 14, 2000
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Abstract
This invention provides methods and systems for identifying and typing toxicity of chemical compositions, as well as for screening new compositions for toxicity. The invention involves detecting alterations in gene or protein expression and hence establishing molecular profiles in isolated mammalian LSCs contacted with various chemical compositions of known and unknown toxicities, and correlating the molecular profiles with toxicities of the chemical compositions.
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