B7-DC variants immunogenic compositions and methods of use thereof
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United States of America Patent
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Apr 10, 2012
Grant Date -
Feb 12, 2009
app pub date -
Jul 11, 2008
filing date -
Jul 13, 2007
priority date (Note) -
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Abstract
Compositions and methods for costimulating T cells (i.e., increasing antigen-specific proliferation of T cells, enhancing cytokine production by T cells, stimulating differentiation ad effector functions of T cells and/or promoting T cell survival) are provided. Suitable compositions include variant B7-DC polypeptides, fragments and fusion proteins thereof. Variant B7-DC polypeptides have reduced binding affinity for the inhibitory PD-1 ligand and substantially retain the ability to costimulate T cells. Methods for using variant B7-DC polypeptides to stimulate immune responses in subjects in need thereof are provided.
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