Method and apparatus for assessing polypeptide aggregation
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United States of America Patent
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Apr 10, 2012
Grant Date -
Oct 14, 2010
app pub date -
Mar 8, 2010
filing date -
Nov 5, 2003
priority date (Note) -
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Abstract
A method of determining aggregation rate data predicting an aggregation rate of a polypeptide defined by an amino acid sequence, the method comprising determining a hydrophobicity value, a charge value, and at least one shape propensity value for said sequence; identifying one or more aggregation-influencing patterns within said sequence; determining a pattern value for the sequence responsive to said identifying; and determining said aggregation rate data by determining a weighted combination of said hydrophobicity value, said charge value, said at least one shape propensity value, said pattern value and at least one factor extrinsic to said amino acid sequence.
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