Demethylation of 14-hydroxy substituted alkaloid derivatives

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Apr 17, 2012
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Jun 25, 2009
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Nov 24, 2008
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Nov 26, 2007

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Abstract

The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5-epoxymorphinane-6-on-derivatives. This is achieved by reacting a starting compound with a compound of general formula R¹OOC—N═N—COOR²in a suitable solvent.

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Inventor Name	Address	# of filed Patents	Total Citations
Bertogg, Andreas	Zurich, CH	2	0
Dinkel, Thomas	Strengelbach, CH	3	6
Heller, Sabrina	Oftringern, CH	3	6
Lauterbach, Erik Heinz	Suhr, CH	3	6

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Demethylation of 14-hydroxy substituted alkaloid derivatives

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United States of America Patent

12292704

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PATENT NO	8158793
APP PUB NO	20090163717A1
SERIAL NO	12292704
DOCKET NO

US Family Size	Non-US Coverage
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DATE PUBLISHED	PUBLICATION/PATENT NO.	PUBLICATION TYPE
April 17, 2012	US,8158793,B2 US8158793B2	GRANTED PATENT AS SECOND PUBLICATION
June 25, 2009	US,20090163717,A1 US20090163717A1	FIRST PUBLISHED PATENT APPLICATION

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