Methods and compositions for combinatorial-based production of multivalent recombinant antigens

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United States of America Patent

PATENT NO

8163533

APP PUB NO

20080318274A1

SERIAL NO

11577303

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Abstract

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The present invention provides methods and compositions for rapidly producing multivalent recombinant vaccines using filamentous fungal heterokaryons. The present invention relies on the use of filamentous fungal heterokaryons that are generated from combinations of two or more parent strains into which recombinant DNA molecules encoding variants of antigens derived from pathogenic organisms have been introduced. The resulting vaccines are multivalent.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
INTREXON CORPORATIONBLACKSBURG, VA116

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cambareri, Edward B La Honda, US 2 0
Stuart, W Dorsey San Francsico, US 9 194

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Intrexon Corporation (1)
6268140 Combinatorial metabolic libraries 4 1999
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
4816405 Vectors for transformation by ascomycetes 25 1987
 
ST. LOUIS UNIVERSITY, A NON-PROFIT ORG. (1)
4486533 Filamentous fungi functional replicating extrachromosomal element 33 1983
 
IMMUNITOR COMPANY LTD. (1)
* 2003/0092,145 Viral vaccine composition, process, and methods of use 38 2001
 
NPS PHARMACEUTICALS, INC. (1)
4885249 Aspergillus niger transformation system 26 1984
 
ZymoGenetics, Inc. (1)
4935349 Expression of higher eucaryotic genes in aspergillus 66 1987
 
UNIVERSITY OF HAWAII (2)
5643745 Heterologous dimeric proteins produced in heterokaryons 32 1994
5683899 Methods and compositions for combinatorial-based discovery of new multimeric molecules 43 1996
* Cited By Examiner

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