US Patent No: 8,163,533
Number of patents in Portfolio can not be more than 2000
Methods and compositions for combinatorial-based production of multivalent recombinant antigens
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Apr 24, 2012
Issued date -
Oct 17, 2005
filing date -
11/577,303
serial no -
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Abstract
The present invention provides methods and compositions for rapidly producing multivalent recombinant vaccines using filamentous fungal heterokaryons. The present invention relies on the use of filamentous fungal heterokaryons that are generated from combinations of two or more parent strains into which recombinant DNA molecules encoding variants of antigens derived from pathogenic organisms have been introduced. The resulting vaccines are multivalent.
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First Claim
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 5,643,745 Heterologous dimeric proteins produced in heterokaryons | 25 | 1994 | |
| 5,683,899 Methods and compositions for combinatorial-based discovery of new multimeric molecules | 32 | 1996 | |
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| 2003/0092,145 Viral vaccine composition, process, and methods of use | 25 | 2001 | |
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| 6,268,140 Combinatorial metabolic libraries | 4 | 1999 | |
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| 4,885,249 Aspergillus niger transformation system | 22 | 1984 | |
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| 4,486,533 Filamentous fungi functional replicating extrachromosomal element | 25 | 1983 | |
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| 4,816,405 Vectors for transformation by ascomycetes | 20 | 1987 | |
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| 4,935,349 Expression of higher eucaryotic genes in aspergillus | 47 | 1987 | |
Patent Citation Ranking
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