Methods and systems for cooling a chromatographic column

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United States of America Patent

PATENT NO 8167987
APP PUB NO 20090277245A1
SERIAL NO

12468314

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Abstract

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Systems and methods for cooling a chromatographic column is disclosed generally, comprising heating a chromatographic column, supplying fluid into the column via the inlet end of the column at an inlet pressure, decreasing the temperature of the column, thereby causing the fluid in the column to contract, and controlling the fluid in the column such that the rate at which the fluid in the column contracts does not exceed the flow rate of the fluid supplied to the column. In certain embodiments, the rate of change of the volume of the fluid in the column as the column temperature decreases is modeled, and the rate of contraction of the gas in the column is estimated therefrom. In some embodiments, the column temperature and/or inlet pressure are controlled by a programmable chromatographic oven.

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Patent Owner(s)

  • PERKINELMER LAS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Tipler, Andrew Trumbull, US 54 870

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