Process for the preparation of pregabalin
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United States of America Patent
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May 1, 2012
Grant Date -
Jul 15, 2010
app pub date -
Mar 24, 2008
filing date -
Jun 25, 2007
priority date (Note) -
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Abstract
The present invention encompasses novel intermediates of pregabalin, namely 3-cyano-5-methyl hexanamide (28) and 3-(amino methyl)-5 methyl hexanamide (29), and processes for their preparation. The invention also encompasses a process for converting the novel pregabalin intermediates into pregabalin, Formula (I): The present invention further provides a cost effective method for the synthesis of (S)-pregabalin, which involves the recovery of mandelic acid and tartaric acid used in the resolution process and recycling them, increasing the yields of the final product formed, which substantially reduced the cost of the production.
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