Antibodies against flagellin and uses thereof
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United States of America Patent
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May 8, 2012
Issued Date -
N/A
app pub date -
Sep 5, 2008
filing date -
Sep 5, 2007
priority date (Note) -
Expired
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Abstract
The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.
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