US Patent No: 8,173,436

Number of patents in Portfolio can not be more than 2000

Biosensor utilizing a resonator having a functionalized surface

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Abstract

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Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.

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First Claim

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Patent Owner(s)

  • INTEL CORPORATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berlin, Andrew San Jose, US 33 368
Ma, Qing San Jose, US 206 3411
Rao, Valluri Saratoga, US 87 1081
Wang, Li-Peng Saratoga, US 71 563
Yamakawa, Mineo Campbell, US 89 839
Zhang, Yuegang Cupertino, US 72 984

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (48)
4,596,697 Chemical sensor matrix 113 1984
4,735,906 Sensor having piezoelectric crystal for microgravimetric immunoassays 72 1984
4,642,508 Piezoelectric resonating device 89 1985
4,789,804 Analytical device and method utilizing a piezoelectric crystal biosensor 137 1986
4,847,193 Signal amplification in an assay employing a piezoelectric oscillator 39 1987
4,999,284 Enzymatically amplified piezoelectric specific binding assay 67 1988
* 5,130,257 Chemical sensor utilizing a surface transverse wave device 50 1988
5,135,852 Piezoelectric cell growth biosensing method using polymer-metabolic product complex interactions 27 1989
5,595,908 Piezoelectric device for detection of polynucleotide hybridization 79 1989
5,129,262 Plate-mode ultrasonic sensor 99 1990
* 5,162,691 Cantilevered air-gap type thin film piezoelectric resonator 111 1991
6,846,654 Catalytic antibodies as chemical sensors 24 1993
5,552,274 Method for detecting target sequences by oscillation frequency 29 1993
5,705,399 Sensor and method for detecting predetermined chemical species in solution 87 1994
5,501,986 Piezoelectric specific binding assay with mass amplified reagents 36 1994
5,789,845 Film bulk acoustic wave device 145 1995
5,814,525 Piezoelectric biosensor with a ladder polymer substrate coating 35 1996
5,852,229 Piezoelectric resonator chemical sensing device 95 1996
5,910,286 Highly selective chemical sensor 48 1996
5,932,953 Method and system for detecting material using piezoelectric resonators 82 1997
5,993,631 Methods of analysis/separation 48 1997
5,936,150 Thin film resonant chemical sensor with resonant acoustic isolator 217 1998
6,289,286 Surface regeneration of biosensors and characterization of biomolecules associated therewith 58 1998
6,156,578 Quartz crystal microbalance system for detecting concentration of a selected gas component in a multicomponent gas stream 25 1998
6,060,818 SBAR structures and method of fabrication of SBAR.FBAR film processing techniques for the manufacturing of SBAR/BAR filters 168 1998
6,630,309 Determination of an analyte in a liquid medium 14 1998
6,358,523 Macromolecule-lipid complexes and methods for making and regulating 17 1998
6,284,475 Assays for diagnosis of thrombophilic disease 12 1998
6,218,507 Synthetic peptides for the detection of trimethylamine (TMA) and their detection method and device 9 1998
* 6,215,375 Bulk acoustic wave resonator with improved lateral mode suppression 130 1999
* 6,386,053 Mass sensor and mass detection method 17 1999
* 6,242,843 Resonator structures 45 1999
6,329,824 Method of measuring resonant frequency of a resonator and coupling degree of two resonators 10 1999
6,458,599 Compositions and methods for capturing, isolating, detecting, analyzing and quantifying macromolecules 18 2000
6,485,984 CALIXCROWN DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF, A SELF-ASSEMBLED MONO-LAYER OF THE CALIXCROWN DERIVATIVES PREPARED BY USING THE SAME AND A PROCESS FOR IMMOBILIZING A PROTEIN MONO-LAYER BY USING THE SELF-ASSEMBLED MONO-LAYER OF THE CALIXCROWN DERIVATIVES 10 2000
6,355,498 Thin film resonators fabricated on membranes created by front side releasing 70 2000
6,514,767 Surface enhanced spectroscopy-active composite nanoparticles 135 2000
2002/0008,443 Thin film, method for manufacturing thin film, and electronic component 8 2001
6,348,795 Crystal resonant frequency sensor 10 2001
6,842,088 Thin film acoustic resonator and method of producing the same 100 2002
2005/0101,841 Healthcare networks with biosensors 266 2002
6,955,787 Integrated biological and chemical sensors 23 2003
2006/0019,373 Biosensor with rf signal transmission 14 2003
2004/0150,296 Material sensing sensor and module using thin film bulk acoustic resonator 75 2004
2005/0153,370 Method of enhancing signal detection of cell-wall components of cells 11 2004
2006/0054,941 Multifunctional biosensor based on ZnO nanostructures 6 2005
* 7,871,569 Biosensor utilizing a resonator having a functionalized surface 4 2005
2006/0160,144 Sensor arrangement, device and method for testing active substances and/or active sites from a pharmacological point of view using an amperometer and/or potentiometer 7 2006
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
* 2012/0227,474 DEVICE COMPRISING A RESONATOR FOR DETECTING AT LEAST ONE SUBSTANCE OF A FLUID, METHOD FOR PRODUCING SAID DEVICE AND METHOD FOR DETECTING AT LEAST ONE SUBSTANCE OF ANOTHER FLUID 0 2010
* Cited By Examiner

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