Biosensor utilizing a resonator having a functionalized surface
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United States of America Patent
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May 8, 2012
Grant Date -
Apr 14, 2011
app pub date -
Dec 14, 2010
filing date -
Dec 30, 2003
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Abstract
Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.
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