Biosensor utilizing a resonator having a functionalized surface

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8173436
APP PUB NO 20110086438A1
SERIAL NO

12967964

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Abstract

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Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
INTEL CORPORATIONSANTA CLARA, CA28565

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berlin, Andrew San Jose, US 33 448
Ma, Qing San Jose, US 206 3698
Rao, Valluri Saratoga, US 87 1148
Wang, Li-Peng Saratoga, US 71 606
Yamakawa, Mineo Campbell, US 89 939
Zhang, Yuegang Cupertino, US 72 1106

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
6955787 Integrated biological and chemical sensors 23 2003
2006/0054,941 Multifunctional biosensor based on ZnO nanostructures 6 2005
 
BIOSENSOR APPLICATIONS SWEDEN AB (1)
6630309 Determination of an analyte in a liquid medium 14 1998
 
The Cooper Union for the Advancement of Science and Art (1)
5705399 Sensor and method for detecting predetermined chemical species in solution 87 1994
 
BINFORMA GROUP LIMITED LIABILITY COMPANY (1)
2005/0101,841 Healthcare networks with biosensors 275 2002
 
TERUMO KABUSHIKI KAISHA (1)
5552274 Method for detecting target sequences by oscillation frequency 29 1993
 
Thomson-CSF (1)
5910286 Highly selective chemical sensor 52 1996
 
Seiko Instruments & Electronics Ltd. (1)
4789804 Analytical device and method utilizing a piezoelectric crystal biosensor 138 1986
 
LIFE SAFETY GERMANY GMBH (1)
6156578 Quartz crystal microbalance system for detecting concentration of a selected gas component in a multicomponent gas stream 25 1998
 
GENE-TRAK SYSTEMS (1)
4847193 Signal amplification in an assay employing a piezoelectric oscillator 40 1987
 
SURROMED, INC. (1)
6514767 Surface enhanced spectroscopy-active composite nanoparticles 137 2000
 
THE TEXAS A&M UNIVERSITY SYSTEM (1)
4735906 Sensor having piezoelectric crystal for microgravimetric immunoassays 74 1984
 
SANDIA CORPORATION (1)
5814525 Piezoelectric biosensor with a ladder polymer substrate coating 35 1996
 
KONINKLIJKE PHILIPS ELECTRONICS N.V. (1)
2006/0019,373 Biosensor with rf signal transmission 14 2003
 
KABUSHIKI KAISHA TOSHIBA (1)
4642508 Piezoelectric resonating device 90 1985
 
The United States of America as represented by the Secretary of the Army (2)
4596697 Chemical sensor matrix 113 1984
* 5162691 Cantilevered air-gap type thin film piezoelectric resonator 113 1991
 
LG ELECTRONICS INC. (1)
2004/0150,296 Material sensing sensor and module using thin film bulk acoustic resonator 75 2004
 
AVAGO TECHNOLOGIES GENERAL IP (SINGAPORE) PTE. LTD. (3)
6060818 SBAR structures and method of fabrication of SBAR.FBAR film processing techniques for the manufacturing of SBAR/BAR filters 173 1998
* 6215375 Bulk acoustic wave resonator with improved lateral mode suppression 135 1999
6355498 Thin film resonators fabricated on membranes created by front side releasing 70 2000
 
IONGATE BIOSCIENCES GMBH (1)
2006/0160,144 Sensor arrangement, device and method for testing active substances and/or active sites from a pharmacological point of view using an amperometer and/or potentiometer 7 2006
 
NEW YORK, MOUNT SINAI SCHOOL OF MEDICINE, UNIVERSITY OF (1)
6284475 Assays for diagnosis of thrombophilic disease 13 1998
 
HEWLETT-PACKARD COMPANY (1)
* 5130257 Chemical sensor utilizing a surface transverse wave device 50 1988
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (2)
5129262 Plate-mode ultrasonic sensor 100 1990
6358523 Macromolecule-lipid complexes and methods for making and regulating 17 1998
 
3M INNOVATIVE PROPERTIES COMPANY (1)
2005/0153,370 Method of enhancing signal detection of cell-wall components of cells 11 2004
 
E. I. DU PONT DE NEMOURS AND COMPANY (2)
4999284 Enzymatically amplified piezoelectric specific binding assay 67 1988
5135852 Piezoelectric cell growth biosensing method using polymer-metabolic product complex interactions 28 1989
 
TELEDYNE SCIENTIFIC & IMAGING, LLC (1)
5936150 Thin film resonant chemical sensor with resonant acoustic isolator 223 1998
 
WELLSTAT BIOCATALYSIS, LLC (1)
6846654 Catalytic antibodies as chemical sensors 26 1993
 
PROTEOGEN, INC. (1)
6485984 CALIXCROWN DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF, A SELF-ASSEMBLED MONO-LAYER OF THE CALIXCROWN DERIVATIVES PREPARED BY USING THE SAME AND A PROCESS FOR IMMOBILIZING A PROTEIN MONO-LAYER BY USING THE SELF-ASSEMBLED MONO-LAYER OF THE CALIXCROWN DERIVATIVES 10 2000
 
MURATA MANUFACTURING CO., LTD. (1)
2002/0008,443 Thin film, method for manufacturing thin film, and electronic component 8 2001
 
BF Goodrich Company (1)
6348795 Crystal resonant frequency sensor 10 2001
 
NOKIA MOBILE PHONES LTD. (1)
* 6242843 Resonator structures 45 1999
 
MEMS SOLUTION CO., LTD. (1)
6842088 Thin film acoustic resonator and method of producing the same 101 2002
 
IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (1)
5932953 Method and system for detecting material using piezoelectric resonators 82 1997
 
INTEL CORPORATION (1)
* 7871569 Biosensor utilizing a resonator having a functionalized surface 4 2005
 
SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH (1)
5501986 Piezoelectric specific binding assay with mass amplified reagents 36 1994
 
KIMBERLY-CLARK WORLDWIDE, INC. (1)
5852229 Piezoelectric resonator chemical sensing device 95 1996
 
Aspira Biosystems, Inc. (1)
6458599 Compositions and methods for capturing, isolating, detecting, analyzing and quantifying macromolecules 20 2000
 
MITSUBISHI DENKI KABUSHIKI KAISHA (1)
5789845 Film bulk acoustic wave device 148 1995
 
DEVELOPMENT CENTER FOR BIOTECHNOLOGY (1)
6218507 Synthetic peptides for the detection of trimethylamine (TMA) and their detection method and device 9 1998
 
UNIVERSITY OF SOUTHERN MISSISSIPPI, THE (1)
5595908 Piezoelectric device for detection of polynucleotide hybridization 79 1989
 
SCIENTIFIC GENERICS LIMITED (1)
5993631 Methods of analysis/separation 48 1997
 
GE HEALTHCARE BIO-SCIENCES AB (1)
6289286 Surface regeneration of biosensors and characterization of biomolecules associated therewith 58 1998
 
NGK INSULATORS, LTD. (1)
* 6386053 Mass sensor and mass detection method 18 1999
 
ADVANCED MOBILE TELECOMMUNICATION TECHNOLOGY INC. (1)
6329824 Method of measuring resonant frequency of a resonator and coupling degree of two resonators 10 1999
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
SIEMENS AKTIENGESELLSCHAFT (1)
* 2012/0227,474 DEVICE COMPRISING A RESONATOR FOR DETECTING AT LEAST ONE SUBSTANCE OF A FLUID, METHOD FOR PRODUCING SAID DEVICE AND METHOD FOR DETECTING AT LEAST ONE SUBSTANCE OF ANOTHER FLUID 0 2010
* Cited By Examiner

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