Neuroprotective effect of solubilized UDCA in focal ischemic model
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United States of America Patent
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May 8, 2012
Grant Date -
Mar 9, 2006
app pub date -
Aug 30, 2005
filing date -
Aug 30, 2004
priority date (Note) -
Expired
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Abstract
The present disclosure provides compositions and methods for treating, ameliorating, or relieving at least one symptom associated with loss of blood flow to the brain including, without limitation, ischemic stroke. Compositions of the disclosure may comprise a bile acid compound and a carbohydrate, wherein both materials remain in solution for all pH values of the solution within a selected range of pH values. Symptoms may include infarct volume, functional recovery, apoptosis, and/or eNOS expression.
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