Methods and means for obtaining modified phenotypes
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United States of America Patent
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May 22, 2012
Grant Date -
Nov 10, 2005
app pub date -
Jul 13, 2005
filing date -
Aug 13, 1999
priority date (Note) -
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Abstract
Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated, target-specific RNA is provided by transcription of a chimeric gene comprising a promoter and a DNA region encoding the target-specific RNA.
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