Pharmaceutically acceptable propylene glycol solvate of naproxen
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United States of America Patent
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May 22, 2012
Grant Date -
Nov 4, 2010
app pub date -
Jul 20, 2010
filing date -
Dec 30, 2002
priority date (Note) -
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Abstract
The invention relates to pharmaceutical compositions comprising propylene glycol solvates of APIs. In particular a 2:1 complex of naproxen sodium to propylene glycol is disclosed which is a crystalline solid. The complex is prepared by crystallization of a mixture of naproxen sodium and propylene glycol from diethyl ether. It is identifiable by its X-ray powder diffraction pattern described herein.
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